Rapid Reconstruction of Extremely Accelerated Liver 4D MRI via Chained Iterative Refinement
This work addresses the need for faster and clinically deployable 4D MRI reconstruction in medical imaging, offering a novel method that improves over existing baselines.
The paper tackled the problem of long scanning times for high-quality 4D liver MRI by proposing CIRNet, which uses a denoising diffusion framework to reconstruct images from accelerated sparse sampling, achieving superior performance with up to 30-times acceleration and an inference time of 11 seconds.
Abstract Purpose: High-quality 4D MRI requires an impractically long scanning time for dense k-space signal acquisition covering all respiratory phases. Accelerated sparse sampling followed by reconstruction enhancement is desired but often results in degraded image quality and long reconstruction time. We hereby propose the chained iterative reconstruction network (CIRNet) for efficient sparse-sampling reconstruction while maintaining clinically deployable quality. Methods: CIRNet adopts the denoising diffusion probabilistic framework to condition the image reconstruction through a stochastic iterative denoising process. During training, a forward Markovian diffusion process is designed to gradually add Gaussian noise to the densely sampled ground truth (GT), while CIRNet is optimized to iteratively reverse the Markovian process from the forward outputs. At the inference stage, CIRNet performs the reverse process solely to recover signals from noise, conditioned upon the undersampled input. CIRNet processed the 4D data (3D+t) as temporal slices (2D+t). The proposed framework is evaluated on a data cohort consisting of 48 patients (12332 temporal slices) who underwent free-breathing liver 4D MRI. 3-, 6-, 10-, 20- and 30-times acceleration were examined with a retrospective random undersampling scheme. Compressed sensing (CS) reconstruction with a spatiotemporal constraint and a recently proposed deep network, Re-Con-GAN, are selected as baselines. Results: CIRNet consistently achieved superior performance compared to CS and Re-Con-GAN. The inference time of CIRNet, CS, and Re-Con-GAN are 11s, 120s, and 0.15s. Conclusion: A novel framework, CIRNet, is presented. CIRNet maintains useable image quality for acceleration up to 30 times, significantly reducing the burden of 4DMRI.