FgC2F-UDiff: Frequency-guided and Coarse-to-fine Unified Diffusion Model for Multi-modality Missing MRI Synthesis
This addresses a critical issue in clinical practice and research where incomplete MRI data limits diagnosis and treatment, though it appears incremental as it builds on existing diffusion models.
The paper tackles the problem of missing MRI modalities in brain tumor diagnosis by proposing FgC2F-UDiff, a diffusion model that synthesizes missing images, achieving superior performance on two datasets as measured by metrics like PSNR, SSIM, LPIPS, and FID.
Multi-modality magnetic resonance imaging (MRI) is essential for the diagnosis and treatment of brain tumors. However, missing modalities are commonly observed due to limitations in scan time, scan corruption, artifacts, motion, and contrast agent intolerance. Synthesis of missing MRI has been a means to address the limitations of modality insufficiency in clinical practice and research. However, there are still some challenges, such as poor generalization, inaccurate non-linear mapping, and slow processing speeds. To address the aforementioned issues, we propose a novel unified synthesis model, the Frequency-guided and Coarse-to-fine Unified Diffusion Model (FgC2F-UDiff), designed for multiple inputs and outputs. Specifically, the Coarse-to-fine Unified Network (CUN) fully exploits the iterative denoising properties of diffusion models, from global to detail, by dividing the denoising process into two stages, coarse and fine, to enhance the fidelity of synthesized images. Secondly, the Frequency-guided Collaborative Strategy (FCS) harnesses appropriate frequency information as prior knowledge to guide the learning of a unified, highly non-linear mapping. Thirdly, the Specific-acceleration Hybrid Mechanism (SHM) integrates specific mechanisms to accelerate the diffusion model and enhance the feasibility of many-to-many synthesis. Extensive experimental evaluations have demonstrated that our proposed FgC2F-UDiff model achieves superior performance on two datasets, validated through a comprehensive assessment that includes both qualitative observations and quantitative metrics, such as PSNR SSIM, LPIPS, and FID.