Motif Discovery Framework for Psychiatric EEG Data Classification
This addresses the need for earlier assessment of antidepressant response to reduce emotional and economic burdens for patients and clinicians, though it is incremental in applying motif discovery to a new domain.
The paper tackles the problem of predicting depression treatment response by classifying EEG data from the 7th day of treatment, achieving high classification precision across multiple psychiatric datasets.
In current medical practice, patients undergoing depression treatment must wait four to six weeks before a clinician can assess medication response due to the delayed noticeable effects of antidepressants. Identification of a treatment response at any earlier stage is of great importance, since it can reduce the emotional and economic burden connected with the treatment. We approach the prediction of a patient response to a treatment as a classification problem, by utilizing the dynamic properties of EEG recordings on the 7th day of the treatment. We present a novel framework that applies motif discovery to extract meaningful features from EEG data distinguishing between depression treatment responders and non-responders. We applied our framework also to classification tasks in other psychiatric EEG datasets, namely to patients with symptoms of schizophrenia, pediatric patients with intractable seizures, and Alzheimer disease and dementia. We achieved high classification precision in all data sets. The results demonstrate that the dynamic properties of the EEGs may support clinicians in decision making both in diagnosis and in the prediction depression treatment response as early as on the 7th day of the treatment. To our best knowledge, our work is the first one using motifs in the depression diagnostics in general.