WiseMind: Recontextualizing AI with a Knowledge-Guided, Theory-Informed Multi-Agent Framework for Instrumental and Humanistic Benefits
This addresses the problem of translating NLP into clinical practice for psychiatric diagnosis, offering both instrumental and humanistic benefits, though it is incremental in its domain-specific approach.
The paper tackled the challenge of insufficient contextualization in applying NLP to psychiatric differential diagnosis, achieving up to 84.2% diagnostic accuracy comparable to human experts while improving perceived empathy and trustworthiness.
Translating state-of-the-art NLP into practice often stalls at the "last mile" owing to insufficient contextualization of the target domain's knowledge, processes, and evaluation. Psychiatric differential diagnosis exemplifies this challenge: accurate assessments depend on nuanced clinical knowledge, a delicate cognitive-affective interview process, and downstream outcomes that extend far beyond benchmark accuracy. We present WiseMind, a systematic interdisciplinary contextualization framework that delivers both instrumental (diagnostic precision) and humanistic (empathy) gains. WiseMind comprises three components:(i) structured knowledge-guided proactive reasoning, which embeds DSM-5 criteria in a knowledge graph to steer questioning; (ii) a theory-informed dual-agent architecture that coordinates a "reasonable-mind" reasoning agent and an "emotional-mind" empathy agent, inspired by Dialectical Behavior Therapy; and (iii) a multi-faceted evaluation strategy covering simulated patients, user studies, clinician review, and ethical assessment. Tested on depression, anxiety, and bipolar disorder, WiseMind attains up to 84.2% diagnostic accuracy, which is comparable to human experts, while outperforming single-agent baselines in perceived empathy and trustworthiness. These results show that deep contextualization-across knowledge, process, and evaluation layers-can transform benchmark-driven NLP into clinically meaningful impact.