GBT-SAM: Adapting a Foundational Deep Learning Model for Generalizable Brain Tumor Segmentation via Efficient Integration of Multi-Parametric MRI Data
This work addresses the need for accurate and efficient brain tumor segmentation in clinical settings, offering a domain-robust and computationally efficient solution that is incremental in adapting a foundational model.
The paper tackles the problem of brain tumor segmentation from multi-parametric MRI data by adapting the Segment Anything Model (SAM) into GBT-SAM, achieving a Dice Score of 93.54 on the BraTS Adult Glioma dataset and robust performance across other tumor types with only 6.5M trainable parameters.
Gliomas are aggressive brain tumors that require accurate imaging-based diagnosis, with segmentation playing a critical role in evaluating morphology and treatment decisions. Manual delineation of gliomas is time-consuming and prone to variability, motivating the use of deep learning to improve consistency and alleviate clinical workload. However, existing methods often fail to fully exploit the information available in multi-parametric MRI (mp-MRI), particularly inter-slice contextual features, and typically require considerable computational resources while lacking robustness across tumor type variations. We present GBT-SAM, a parameter-efficient deep learning framework that adapts the Segment Anything Model (SAM), a large-scale vision model, to volumetric mp-MRI data. GBT-SAM reduces input complexity by selecting fewer than 2.6\% of slices per scan while incorporating all four MRI modalities, preserving essential tumor-related information with minimal cost. Furthermore, our model is trained by a two-step fine-tuning strategy that incorporates a depth-aware module to capture inter-slice correlations and lightweight adaptation layers, resulting in just 6.5M trainable parameters, which is the lowest among SAM-based approaches. GBT-SAM achieves a Dice Score of 93.54 on the BraTS Adult Glioma dataset and demonstrates robust performance on Meningioma, Pediatric Glioma, and Sub-Saharan Glioma datasets. These results highlight GBT-SAM's potential as a computationally efficient and domain-robust framework for brain tumor segmentation using mp-MRI. Our code and models are available at https://github.com/vpulab/med-sam-brain .