Contrast-Invariant Self-supervised Segmentation for Quantitative Placental MRI
This work addresses a domain-specific problem in medical imaging for placental analysis, offering a novel approach but with incremental technical advancements.
The paper tackles the challenge of placental segmentation in T2*-weighted MRI by proposing a contrast-augmented framework that leverages multi-echo data, resulting in improved generalization across echo times and outperforming baseline methods.
Accurate placental segmentation is essential for quantitative analysis of the placenta. However, this task is particularly challenging in T2*-weighted placental imaging due to: (1) weak and inconsistent boundary contrast across individual echoes; (2) the absence of manual ground truth annotations for all echo times; and (3) motion artifacts across echoes caused by fetal and maternal movement. In this work, we propose a contrast-augmented segmentation framework that leverages complementary information across multi-echo T2*-weighted MRI to learn robust, contrast-invariant representations. Our method integrates: (i) masked autoencoding (MAE) for self-supervised pretraining on unlabeled multi-echo slices; (ii) masked pseudo-labeling (MPL) for unsupervised domain adaptation across echo times; and (iii) global-local collaboration to align fine-grained features with global anatomical context. We further introduce a semantic matching loss to encourage representation consistency across echoes of the same subject. Experiments on a clinical multi-echo placental MRI dataset demonstrate that our approach generalizes effectively across echo times and outperforms both single-echo and naive fusion baselines. To our knowledge, this is the first work to systematically exploit multi-echo T2*-weighted MRI for placental segmentation.