Symptom-Driven Personalized Proton Pump Inhibitors Therapy Using Bayesian Neural Networks and Model Predictive Control
This work addresses the challenge of personalized proton pump inhibitor therapy for patients with gastric acid disorders to minimize treatment burden and overdose risk, representing a novel application but incremental in method.
The paper tackled the problem of precise long-term control of gastric acidity for proton pump inhibitor therapy by proposing a noninvasive, symptom-based framework using Bayesian neural networks and model predictive control, resulting in a 65% reduction in total PPI consumption compared to standard fixed regimens while maintaining acid suppression with at least 95% probability.
Proton Pump Inhibitors (PPIs) are the standard of care for gastric acid disorders but carry significant risks when administered chronically at high doses. Precise long-term control of gastric acidity is challenged by the impracticality of invasive gastric acid monitoring beyond 72 hours and wide inter-patient variability. We propose a noninvasive, symptom-based framework that tailors PPI dosing solely on patient-reported reflux and digestive symptom patterns. A Bayesian Neural Network prediction model learns to predict patient symptoms and quantifies its uncertainty from historical symptom scores, meal, and PPIs intake data. These probabilistic forecasts feed a chance-constrained Model Predictive Control (MPC) algorithm that dynamically computes future PPI doses to minimize drug usage while enforcing acid suppression with high confidence - without any direct acid measurement. In silico studies over diverse dietary schedules and virtual patient profiles demonstrate that our learning-augmented MPC reduces total PPI consumption by 65 percent compared to standard fixed regimens, while maintaining acid suppression with at least 95 percent probability. The proposed approach offers a practical path to personalized PPI therapy, minimizing treatment burden and overdose risk without invasive sensors.