The Brain Resection Multimodal Image Registration (ReMIND2Reg) 2025 Challenge
This addresses the critical need for accurate intraoperative image guidance in neurosurgery to improve patient outcomes, but it is incremental as it focuses on establishing a standardized evaluation framework rather than proposing a new method.
The ReMIND2Reg 2025 Challenge tackles the problem of aligning post-resection intraoperative ultrasound with preoperative MRI to correct brain shift in brain tumor surgery, providing the largest public benchmark with 99 training cases and 10 test cases evaluated on target registration error and robustness metrics.
Accurate intraoperative image guidance is critical for achieving maximal safe resection in brain tumor surgery, yet neuronavigation systems based on preoperative MRI lose accuracy during the procedure due to brain shift. Aligning post-resection intraoperative ultrasound (iUS) with preoperative MRI can restore spatial accuracy by estimating brain shift deformations, but it remains a challenging problem given the large anatomical and topological changes and substantial modality intensity gap. The ReMIND2Reg 2025 Challenge provides the largest public benchmark for this task, built upon the ReMIND dataset. It offers 99 training cases, 5 validation cases, and 10 private test cases comprising paired 3D ceT1 MRI, T2 MRI, and post-resection 3D iUS volumes. Data are provided without annotations for training, while validation and test performance are evaluated on manually annotated anatomical landmarks. Metrics include target registration error (TRE), robustness to worst-case landmark misalignment (TRE30), and runtime. By establishing a standardized evaluation framework for this clinically critical and technically complex problem, ReMIND2Reg aims to accelerate the development of robust, generalizable, and clinically deployable multimodal registration algorithms for image-guided neurosurgery.