CardioMorphNet: Cardiac Motion Prediction Using a Shape-Guided Bayesian Recurrent Deep Network
This work addresses cardiac motion estimation for medical imaging applications, offering an incremental improvement by integrating shape guidance and Bayesian modeling into existing deep learning frameworks.
The paper tackles the problem of accurately estimating cardiac motion from cine cardiac magnetic resonance images, which is crucial for assessing cardiac function, and proposes CardioMorphNet, a shape-guided Bayesian recurrent deep network that outperforms state-of-the-art methods by focusing on anatomical regions without intensity-based losses.
Accurate cardiac motion estimation from cine cardiac magnetic resonance (CMR) images is vital for assessing cardiac function and detecting its abnormalities. Existing methods often struggle to capture heart motion accurately because they rely on intensity-based image registration similarity losses that may overlook cardiac anatomical regions. To address this, we propose CardioMorphNet, a recurrent Bayesian deep learning framework for 3D cardiac shape-guided deformable registration using short-axis (SAX) CMR images. It employs a recurrent variational autoencoder to model spatio-temporal dependencies over the cardiac cycle and two posterior models for bi-ventricular segmentation and motion estimation. The derived loss function from the Bayesian formulation guides the framework to focus on anatomical regions by recursively registering segmentation maps without using intensity-based image registration similarity loss, while leveraging sequential SAX volumes and spatio-temporal features. The Bayesian modelling also enables computation of uncertainty maps for the estimated motion fields. Validated on the UK Biobank dataset by comparing warped mask shapes with ground truth masks, CardioMorphNet demonstrates superior performance in cardiac motion estimation, outperforming state-of-the-art methods. Uncertainty assessment shows that it also yields lower uncertainty values for estimated motion fields in the cardiac region compared with other probabilistic-based cardiac registration methods, indicating higher confidence in its predictions.