AIOct 5, 2025

Doctor-R1: Mastering Clinical Inquiry with Experiential Agentic Reinforcement Learning

arXiv:2510.04284v15 citationsh-index: 5Has Code
Originality Incremental advance
AI Analysis

This addresses the gap in AI for real-world clinical scenarios by enhancing consultation skills, though it is incremental as it builds on existing LLM capabilities.

The paper tackled the problem of AI agents lacking strategic and empathetic consultation skills in clinical settings, proposing Doctor-R1, which surpassed state-of-the-art models in benchmarks like HealthBench and MAQuE with higher parameter efficiency and strong human preference in evaluations.

The professionalism of a human doctor in outpatient service depends on two core abilities: the ability to make accurate medical decisions and the medical consultation skill to conduct strategic, empathetic patient inquiry. Existing Large Language Models (LLMs) have achieved remarkable accuracy on medical decision-making benchmarks. However, they often lack the ability to conduct the strategic and empathetic consultation, which is essential for real-world clinical scenarios. To address this gap, we propose Doctor-R1, an AI doctor agent trained to master both of the capabilities by ask high-yield questions and conduct strategic multi-turn inquiry to guide decision-making. Our framework introduces three key components: a multi-agent interactive environment, a two-tiered reward architecture that separately optimizes clinical decision-making and communicative inquiry skills, and an experience repository to ground policy learning in high-quality prior trajectories. We evaluate Doctor-R1 on OpenAI's HealthBench and MAQuE, assessed across multi-facet metrics, such as communication quality, user experience, and task accuracy. Remarkably, Doctor-R1 surpasses state-of-the-art open-source specialized LLMs by a substantial margin with higher parameter efficiency and outperforms powerful proprietary models. Furthermore, the human evaluations show a strong preference for Doctor-R1 to generate human-preferred clinical dialogue, demonstrating the effectiveness of the framework.

Foundations

The foundational work for this paper's niche, ranked by how specifically the neighbourhood builds on it — not by global fame.

Your Notes