QuanvNeXt: An end-to-end quanvolutional neural network for EEG-based detection of major depressive disorder
This provides an efficient and reliable approach for diagnosing major depressive disorder using EEG data, though it appears incremental as it builds on existing quanvolutional methods with specific improvements.
The study tackled EEG-based detection of major depressive disorder by developing QuanvNeXt, an end-to-end fully quanvolutional model, which achieved an average accuracy of 93.1% and AUC-ROC of 97.2%, outperforming state-of-the-art baselines.
This study presents QuanvNeXt, an end-to-end fully quanvolutional model for EEG-based depression diagnosis. QuanvNeXt incorporates a novel Cross Residual block, which reduces feature homogeneity and strengthens cross-feature relationships while retaining parameter efficiency. We evaluated QuanvNeXt on two open-source datasets, where it achieved an average accuracy of 93.1% and an average AUC-ROC of 97.2%, outperforming state-of-the-art baselines such as InceptionTime (91.7% accuracy, 95.9% AUC-ROC). An uncertainty analysis across Gaussian noise levels demonstrated well-calibrated predictions, with ECE scores remaining low (0.0436, Dataset 1) to moderate (0.1159, Dataset 2) even at the highest perturbation (ε = 0.1). Additionally, a post-hoc explainable AI analysis confirmed that QuanvNeXt effectively identifies and learns spectrotemporal patterns that distinguish between healthy controls and major depressive disorder. Overall, QuanvNeXt establishes an efficient and reliable approach for EEG-based depression diagnosis.