Agentic Personas for Adaptive Scientific Explanations with Knowledge Graphs
This addresses the need for scalable adaptive explainability in complex, high-stakes domains like scientific discovery, offering an incremental improvement over static methods.
The paper tackled the problem of non-adaptive AI explanations in scientific domains by introducing agentic personas to guide explanation generation, resulting in persona-driven explanations matching state-of-the-art predictive performance and reducing feedback requirements by two orders of magnitude.
AI explanation methods often assume a static user model, producing non-adaptive explanations regardless of expert goals, reasoning strategies, or decision contexts. Knowledge graph-based explanations, despite their capacity for grounded, path-based reasoning, inherit this limitation. In complex domains such as scientific discovery, this assumption fails to capture the diversity of cognitive strategies and epistemic stances among experts, preventing explanations that foster deeper understanding and informed decision-making. However, the scarcity of human experts limits the use of direct human feedback to produce adaptive explanations. We present a reinforcement learning approach for scientific explanation generation that incorporates agentic personas, structured representations of expert reasoning strategies, that guide the explanation agent towards specific epistemic preferences. In an evaluation of knowledge graph-based explanations for drug discovery, we tested two personas that capture distinct epistemic stances derived from expert feedback. Results show that persona-driven explanations match state-of-the-art predictive performance while persona preferences closely align with those of their corresponding experts. Adaptive explanations were consistently preferred over non-adaptive baselines (n = 22), and persona-based training reduces feedback requirements by two orders of magnitude. These findings demonstrate how agentic personas enable scalable adaptive explainability for AI systems in complex and high-stakes domains.