Wireless bioelectronics for untethered biohybrid robots
This perspective article summarizes incremental advances in control strategies for biohybrid robots, targeting researchers in robotics and bioengineering.
The paper addresses the challenge of delivering stimulation and control signals to biohybrid robots without tethered wiring, highlighting wireless bioelectronics and optoelectronics as solutions for remote control via radio-frequency magnetic fields and light emitters.
Biohybrid robots integrate living tissues with engineered artificial structures to achieve organism-inspired actuation and behavior. A persistent challenge is delivering stimulation and control signals without relying on tethered wiring or bulky hardware immersed in cell-culture media. Wireless bioelectronics addresses this limitation by enabling the remote transfer of control signals, typically via radio-frequency magnetic fields, to locally stimulate muscle tissues at tissue-electrode interfaces. In parallel, wireless optoelectronics enables remote control of optogenetically modified, muscle-based robots by embedding light emitters that initiate muscle actuation through light-gated ion channels. Further advances incorporate neuromuscular junctions, leveraging biological signal transduction to enable selective control of multiple actuators through wireless frequency- and time-division multiplexing. This perspective article summarizes recent advances in control strategies for biohybrid robots, namely, wireless electrical stimulation, wireless optical stimulation, and neuromuscular integration. Then this describes cross-cutting design principles and highlights a future direction, namely, co-integration of neural organoid-bioelectronics toward autonomous, closed-loop biohybrid robots.