Diffusion-Based Heart Sound Generation: Evaluation with Physiological Signal Metrics, Classifiers, and Expert Listening
For researchers in biomedical signal processing and auscultation training, this provides a practical baseline for diffusion-based PCG generation, though it is incremental as it applies existing methods to a specific domain.
The paper develops a class-conditional diffusion model for heart sound generation and evaluates it using physiological metrics, classifier accuracy (82.8% on synthetic vs 92.24% on real), and expert listening. Results show synthetic clips preserve dominant cycle durations but have reduced periodicity and increased burstiness, with limited abnormality sensitivity.
Publicly available phonocardiogram (PCG) datasets remain limited in size and pathological diversity, constraining both auscultation training and the generalisation of automated heart-sound classifiers. A class-conditional diffusion model for PCG generation is developed in the log-mel domain and synthetic fidelity is assessed using complementary (i) physiology-inspired plausibility metrics, (ii) downstream label-consistency evaluation, and (iii) expert listening. Experiments use the Phy-sioNet/Computing in Cardiology Challenge 2016 dataset (3240 recordings) with recording-level splits. After preprocessing and quality control, 16,749 non-overlapping 4 s clips are mapped to a normalised 1 x 128 x 128 log-mel representation to train a conditional 2D U-Net denoiser with classifier-free guidance. Signal-level plausibility is quantified on reconstructed waveforms using three lightweight metrics: an envelope-autocorrelation rhythm score, an amplitude-based explosion score, and the dominant cycle lag. Synthetic clips preserve similar dominant cycle durations but exhibit reduced envelope periodicity and increased transient burstiness relative to real clips. For downstream evaluation, a ResNet-50 classifier achieves 92.24% accuracy on the held-out real test set and 82.8% accuracy on class-balanced synthetic batches, indicating that generated signals retain discriminative structure relevant to normal/abnormal classification. In a pilot expert listening study (60 clips, two clinicians), most synthetic clips are judged as heart-sound-like, while abnormality sensitivity is low for both real and synthetic 4 s excerpts. Overall, the results provide a practical baseline for diffusion-based PCG generation while highlighting remaining challenges in retaining abnormal acoustic cues and reducing reconstruction-induced artefacts.