Lee W. Cohnstaedt

Mohammad Hossein Samaei, Faryad Darabi Sahneh, Lee W. Cohnstaedt et al.

Large Language Models (LLMs) offer new opportunities to automate complex interdisciplinary research domains. Epidemic modeling, characterized by its complexity and reliance on network science, dynamical systems, epidemiology, and stochastic simulations, represents a prime candidate for leveraging LLM-driven automation. We introduce \textbf{EpidemIQs}, a novel multi-agent LLM framework that integrates user inputs and autonomously conducts literature review, analytical derivation, network modeling, mechanistic modeling, stochastic simulations, data visualization and analysis, and finally documentation of findings in a structured manuscript. We introduced two types of agents: a scientist agent for planning, coordination, reflection, and generation of final results, and a task-expert agent to focus exclusively on one specific duty serving as a tool to the scientist agent. The framework consistently generated complete reports in scientific article format. Specifically, using GPT 4.1 and GPT 4.1 mini as backbone LLMs for scientist and task-expert agents, respectively, the autonomous process completed with average total token usage 870K at a cost of about \$1.57 per study, achieving a 100\% completion success rate through our experiments. We evaluate EpidemIQs across different epidemic scenarios, measuring computational cost, completion success rate, and AI and human expert reviews of generated reports. We compare EpidemIQs to the single-agent LLM, which has the same system prompts and tools, iteratively planning, invoking tools, and revising outputs until task completion. The comparison shows consistently higher performance of the proposed framework across five different scenarios. EpidemIQs represents a step forward in accelerating scientific research by significantly reducing costs and turnaround time of discovery processes, and enhancing accessibility to advanced modeling tools.

Tanvir Ferdousi, Lee W. Cohnstaedt, Caterina M. Scoglio

The performance of data-driven prediction models depends on the availability of data samples for model training. A model that learns about dengue fever incidence in a population uses historical data from that corresponding location. Poor performance in prediction can result in places with inadequate data. This work aims to enhance temporally limited dengue case data by methodological addition of epidemically relevant data from nearby locations as predictors (features). A novel framework is presented for windowing incidence data and computing time-shifted correlation-based metrics to quantify feature relevance. The framework ranks incidence data of adjacent locations around a target location by combining the correlation metric with two other metrics: spatial distance and local prevalence. Recurrent neural network-based prediction models achieve up to 33.6% accuracy improvement on average using the proposed method compared to using training data from the target location only. These models achieved mean absolute error (MAE) values as low as 0.128 on [0,1] normalized incidence data for a municipality with the highest dengue prevalence in Brazil's Espirito Santo. When predicting cases aggregated over geographical ecoregions, the models achieved accuracy improvements up to 16.5%, using only 6.5% of incidence data from ranked feature sets. The paper also includes two techniques for windowing time series data: fixed-sized windows and outbreak detection windows. Both of these techniques perform comparably, while the window detection method uses less data for computations. The framework presented in this paper is application-independent, and it could improve the performances of prediction models where data from spatially adjacent locations are available.