Hongfei Lin

CL
h-index44
21papers
855citations
Novelty51%
AI Score52

21 Papers

1.3CLAug 1, 2023Code
ZRIGF: An Innovative Multimodal Framework for Zero-Resource Image-Grounded Dialogue Generation

Bo Zhang, Jian Wang, Hui Ma et al.

Image-grounded dialogue systems benefit greatly from integrating visual information, resulting in high-quality response generation. However, current models struggle to effectively utilize such information in zero-resource scenarios, mainly due to the disparity between image and text modalities. To overcome this challenge, we propose an innovative multimodal framework, called ZRIGF, which assimilates image-grounded information for dialogue generation in zero-resource situations. ZRIGF implements a two-stage learning strategy, comprising contrastive pre-training and generative pre-training. Contrastive pre-training includes a text-image matching module that maps images and texts into a unified encoded vector space, along with a text-assisted masked image modeling module that preserves pre-training visual features and fosters further multimodal feature alignment. Generative pre-training employs a multimodal fusion module and an information transfer module to produce insightful responses based on harmonized multimodal representations. Comprehensive experiments conducted on both text-based and image-grounded dialogue datasets demonstrate ZRIGF's efficacy in generating contextually pertinent and informative responses. Furthermore, we adopt a fully zero-resource scenario in the image-grounded dialogue dataset to demonstrate our framework's robust generalization capabilities in novel domains. The code is available at https://github.com/zhangbo-nlp/ZRIGF.

14.2IRMay 9, 2022Code
Price DOES Matter! Modeling Price and Interest Preferences in Session-based Recommendation

Xiaokun Zhang, Bo Xu, Liang Yang et al.

Session-based recommendation aims to predict items that an anonymous user would like to purchase based on her short behavior sequence. The current approaches towards session-based recommendation only focus on modeling users' interest preferences, while they all ignore a key attribute of an item, i.e., the price. Many marketing studies have shown that the price factor significantly influences users' behaviors and the purchase decisions of users are determined by both price and interest preferences simultaneously. However, it is nontrivial to incorporate price preferences for session-based recommendation. Firstly, it is hard to handle heterogeneous information from various features of items to capture users' price preferences. Secondly, it is difficult to model the complex relations between price and interest preferences in determining user choices. To address the above challenges, we propose a novel method Co-guided Heterogeneous Hypergraph Network (CoHHN) for session-based recommendation. Towards the first challenge, we devise a heterogeneous hypergraph to represent heterogeneous information and rich relations among them. A dual-channel aggregating mechanism is then designed to aggregate various information in the heterogeneous hypergraph. After that, we extract users' price preferences and interest preferences via attention layers. As to the second challenge, a co-guided learning scheme is designed to model the relations between price and interest preferences and enhance the learning of each other. Finally, we predict user actions based on item features and users' price and interest preferences. Extensive experiments on three real-world datasets demonstrate the effectiveness of the proposed CoHHN. Further analysis reveals the significance of price for session-based recommendation.

23.2AIOct 31, 2023Code
A Transformer-Based Model With Self-Distillation for Multimodal Emotion Recognition in Conversations

Hui Ma, Jian Wang, Hongfei Lin et al.

Emotion recognition in conversations (ERC), the task of recognizing the emotion of each utterance in a conversation, is crucial for building empathetic machines. Existing studies focus mainly on capturing context- and speaker-sensitive dependencies on the textual modality but ignore the significance of multimodal information. Different from emotion recognition in textual conversations, capturing intra- and inter-modal interactions between utterances, learning weights between different modalities, and enhancing modal representations play important roles in multimodal ERC. In this paper, we propose a transformer-based model with self-distillation (SDT) for the task. The transformer-based model captures intra- and inter-modal interactions by utilizing intra- and inter-modal transformers, and learns weights between modalities dynamically by designing a hierarchical gated fusion strategy. Furthermore, to learn more expressive modal representations, we treat soft labels of the proposed model as extra training supervision. Specifically, we introduce self-distillation to transfer knowledge of hard and soft labels from the proposed model to each modality. Experiments on IEMOCAP and MELD datasets demonstrate that SDT outperforms previous state-of-the-art baselines.

2.5CLJul 10, 2023
Hate Speech Detection via Dual Contrastive Learning

Junyu Lu, Hongfei Lin, Xiaokun Zhang et al.

The fast spread of hate speech on social media impacts the Internet environment and our society by increasing prejudice and hurting people. Detecting hate speech has aroused broad attention in the field of natural language processing. Although hate speech detection has been addressed in recent work, this task still faces two inherent unsolved challenges. The first challenge lies in the complex semantic information conveyed in hate speech, particularly the interference of insulting words in hate speech detection. The second challenge is the imbalanced distribution of hate speech and non-hate speech, which may significantly deteriorate the performance of models. To tackle these challenges, we propose a novel dual contrastive learning (DCL) framework for hate speech detection. Our framework jointly optimizes the self-supervised and the supervised contrastive learning loss for capturing span-level information beyond the token-level emotional semantics used in existing models, particularly detecting speech containing abusive and insulting words. Moreover, we integrate the focal loss into the dual contrastive learning framework to alleviate the problem of data imbalance. We conduct experiments on two publicly available English datasets, and experimental results show that the proposed model outperforms the state-of-the-art models and precisely detects hate speeches.

0.5CLAug 18, 2023
KESDT: knowledge enhanced shallow and deep Transformer for detecting adverse drug reactions

Yunzhi Qiu, Xiaokun Zhang, Weiwei Wang et al.

Adverse drug reaction (ADR) detection is an essential task in the medical field, as ADRs have a gravely detrimental impact on patients' health and the healthcare system. Due to a large number of people sharing information on social media platforms, an increasing number of efforts focus on social media data to carry out effective ADR detection. Despite having achieved impressive performance, the existing methods of ADR detection still suffer from three main challenges. Firstly, researchers have consistently ignored the interaction between domain keywords and other words in the sentence. Secondly, social media datasets suffer from the challenges of low annotated data. Thirdly, the issue of sample imbalance is commonly observed in social media datasets. To solve these challenges, we propose the Knowledge Enhanced Shallow and Deep Transformer(KESDT) model for ADR detection. Specifically, to cope with the first issue, we incorporate the domain keywords into the Transformer model through a shallow fusion manner, which enables the model to fully exploit the interactive relationships between domain keywords and other words in the sentence. To overcome the low annotated data, we integrate the synonym sets into the Transformer model through a deep fusion manner, which expands the size of the samples. To mitigate the impact of sample imbalance, we replace the standard cross entropy loss function with the focal loss function for effective model training. We conduct extensive experiments on three public datasets including TwiMed, Twitter, and CADEC. The proposed KESDT outperforms state-of-the-art baselines on F1 values, with relative improvements of 4.87%, 47.83%, and 5.73% respectively, which demonstrates the effectiveness of our proposed KESDT.

3.4CLAug 16, 2024Code
Integrating Multi-view Analysis: Multi-view Mixture-of-Expert for Textual Personality Detection

Haohao Zhu, Xiaokun Zhang, Junyu Lu et al.

Textual personality detection aims to identify personality traits by analyzing user-generated content. To achieve this effectively, it is essential to thoroughly examine user-generated content from various perspectives. However, previous studies have struggled with automatically extracting and effectively integrating information from multiple perspectives, thereby limiting their performance on personality detection. To address these challenges, we propose the Multi-view Mixture-of-Experts Model for Textual Personality Detection (MvP). MvP introduces a Multi-view Mixture-of-Experts (MoE) network to automatically analyze user posts from various perspectives. Additionally, it employs User Consistency Regularization to mitigate conflicts among different perspectives and learn a multi-view generic user representation. The model's training is optimized via a multi-task joint learning strategy that balances supervised personality detection with self-supervised user consistency constraints. Experimental results on two widely-used personality detection datasets demonstrate the effectiveness of the MvP model and the benefits of automatically analyzing user posts from diverse perspectives for textual personality detection.

6.6CLAug 6, 2024Code
Empathy Level Alignment via Reinforcement Learning for Empathetic Response Generation

Hui Ma, Bo Zhang, Bo Xu et al.

Empathetic response generation, aiming to understand the user's situation and feelings and respond empathically, is crucial in building human-like dialogue systems. Traditional approaches typically employ maximum likelihood estimation as the optimization objective during training, yet fail to align the empathy levels between generated and target responses. To this end, we propose an empathetic response generation framework using reinforcement learning (EmpRL). The framework develops an effective empathy reward function and generates empathetic responses by maximizing the expected reward through reinforcement learning. EmpRL utilizes the pre-trained T5 model as the generator and further fine-tunes it to initialize the policy. To align the empathy levels between generated and target responses within a given context, an empathy reward function containing three empathy communication mechanisms -- emotional reaction, interpretation, and exploration -- is constructed using pre-designed and pre-trained empathy identifiers. During reinforcement learning training, the proximal policy optimization algorithm is used to fine-tune the policy, enabling the generation of empathetic responses. Both automatic and human evaluations demonstrate that the proposed EmpRL framework significantly improves the quality of generated responses, enhances the similarity in empathy levels between generated and target responses, and produces empathetic responses covering both affective and cognitive aspects.

4.8CLMay 16, 2024Code
Distilling Implicit Multimodal Knowledge into Large Language Models for Zero-Resource Dialogue Generation

Bo Zhang, Hui Ma, Jian Ding et al.

Integrating multimodal knowledge into large language models (LLMs) represents a significant advancement in dialogue generation capabilities. However, the effective incorporation of such knowledge in zero-resource scenarios remains a substantial challenge due to the scarcity of diverse, high-quality dialogue datasets. To address this, we propose the Visual Implicit Knowledge Distillation Framework (VIKDF), an innovative approach aimed at enhancing LLMs for enriched dialogue generation in zero-resource contexts by leveraging implicit multimodal knowledge. VIKDF comprises two main stages: knowledge distillation, using an Implicit Query Transformer to extract and encode visual implicit knowledge from image-text pairs into knowledge vectors; and knowledge integration, employing a novel Bidirectional Variational Information Fusion technique to seamlessly integrate these distilled vectors into LLMs. This enables the LLMs to generate dialogues that are not only coherent and engaging but also exhibit a deep understanding of the context through implicit multimodal cues, effectively overcoming the limitations of zero-resource scenarios. Our extensive experimentation across two dialogue datasets shows that VIKDF outperforms existing state-of-the-art models in generating high-quality dialogues. The code is available at https://github.com/zhangbo-nlp/VIKDF.

13.9CLJun 8, 2025Code
Cultural Bias Matters: A Cross-Cultural Benchmark Dataset and Sentiment-Enriched Model for Understanding Multimodal Metaphors

Senqi Yang, Dongyu Zhang, Jing Ren et al.

Metaphors are pervasive in communication, making them crucial for natural language processing (NLP). Previous research on automatic metaphor processing predominantly relies on training data consisting of English samples, which often reflect Western European or North American biases. This cultural skew can lead to an overestimation of model performance and contributions to NLP progress. However, the impact of cultural bias on metaphor processing, particularly in multimodal contexts, remains largely unexplored. To address this gap, we introduce MultiMM, a Multicultural Multimodal Metaphor dataset designed for cross-cultural studies of metaphor in Chinese and English. MultiMM consists of 8,461 text-image advertisement pairs, each accompanied by fine-grained annotations, providing a deeper understanding of multimodal metaphors beyond a single cultural domain. Additionally, we propose Sentiment-Enriched Metaphor Detection (SEMD), a baseline model that integrates sentiment embeddings to enhance metaphor comprehension across cultural backgrounds. Experimental results validate the effectiveness of SEMD on metaphor detection and sentiment analysis tasks. We hope this work increases awareness of cultural bias in NLP research and contributes to the development of fairer and more inclusive language models. Our dataset and code are available at https://github.com/DUTIR-YSQ/MultiMM.

2.7CLNov 28, 2025Code
Visual Puns from Idioms: An Iterative LLM-T2IM-MLLM Framework

Kelaiti Xiao, Liang Yang, Dongyu Zhang et al.

We study idiom-based visual puns--images that align an idiom's literal and figurative meanings--and present an iterative framework that coordinates a large language model (LLM), a text-to-image model (T2IM), and a multimodal LLM (MLLM) for automatic generation and evaluation. Given an idiom, the system iteratively (i) generates detailed visual prompts, (ii) synthesizes an image, (iii) infers the idiom from the image, and (iv) refines the prompt until recognition succeeds or a step limit is reached. Using 1,000 idioms as inputs, we synthesize a corresponding dataset of visual pun images with paired prompts, enabling benchmarking of both generation and understanding. Experiments across 10 LLMs, 10 MLLMs, and one T2IM (Qwen-Image) show that MLLM choice is the primary performance driver: GPT achieves the highest accuracies, Gemini follows, and the best open-source MLLM (Gemma) is competitive with some closed models. On the LLM side, Claude attains the strongest average performance for prompt generation.

2.7CLSep 10, 2025Code
CommonVoice-SpeechRE and RPG-MoGe: Advancing Speech Relation Extraction with a New Dataset and Multi-Order Generative Framework

Jinzhong Ning, Paerhati Tulajiang, Yingying Le et al.

Speech Relation Extraction (SpeechRE) aims to extract relation triplets directly from speech. However, existing benchmark datasets rely heavily on synthetic data, lacking sufficient quantity and diversity of real human speech. Moreover, existing models also suffer from rigid single-order generation templates and weak semantic alignment, substantially limiting their performance. To address these challenges, we introduce CommonVoice-SpeechRE, a large-scale dataset comprising nearly 20,000 real-human speech samples from diverse speakers, establishing a new benchmark for SpeechRE research. Furthermore, we propose the Relation Prompt-Guided Multi-Order Generative Ensemble (RPG-MoGe), a novel framework that features: (1) a multi-order triplet generation ensemble strategy, leveraging data diversity through diverse element orders during both training and inference, and (2) CNN-based latent relation prediction heads that generate explicit relation prompts to guide cross-modal alignment and accurate triplet generation. Experiments show our approach outperforms state-of-the-art methods, providing both a benchmark dataset and an effective solution for real-world SpeechRE. The source code and dataset are publicly available at https://github.com/NingJinzhong/SpeechRE_RPG_MoGe.

0.6CLNov 21, 2019Code
Chemical-protein Interaction Extraction via Gaussian Probability Distribution and External Biomedical Knowledge

Cong Sun, Zhihao Yang, Leilei Su et al.

Motivation: The biomedical literature contains a wealth of chemical-protein interactions (CPIs). Automatically extracting CPIs described in biomedical literature is essential for drug discovery, precision medicine, as well as basic biomedical research. Most existing methods focus only on the sentence sequence to identify these CPIs. However, the local structure of sentences and external biomedical knowledge also contain valuable information. Effective use of such information may improve the performance of CPI extraction. Results: In this paper, we propose a novel neural network-based approach to improve CPI extraction. Specifically, the approach first employs BERT to generate high-quality contextual representations of the title sequence, instance sequence, and knowledge sequence. Then, the Gaussian probability distribution is introduced to capture the local structure of the instance. Meanwhile, the attention mechanism is applied to fuse the title information and biomedical knowledge, respectively. Finally, the related representations are concatenated and fed into the softmax function to extract CPIs. We evaluate our proposed model on the CHEMPROT corpus. Our proposed model is superior in performance as compared with other state-of-the-art models. The experimental results show that the Gaussian probability distribution and external knowledge are complementary to each other. Integrating them can effectively improve the CPI extraction performance. Furthermore, the Gaussian probability distribution can effectively improve the extraction performance of sentences with overlapping relations in biomedical relation extraction tasks. Availability: Data and code are available at https://github.com/CongSun-dlut/CPI_extraction. Contact: yangzh@dlut.edu.cn, wangleibihami@gmail.com Supplementary information: Supplementary data are available at Bioinformatics online.

12.8IRApr 19, 2024Code
FineRec:Exploring Fine-grained Sequential Recommendation

Xiaokun Zhang, Bo Xu, Youlin Wu et al.

Sequential recommendation is dedicated to offering items of interest for users based on their history behaviors. The attribute-opinion pairs, expressed by users in their reviews for items, provide the potentials to capture user preferences and item characteristics at a fine-grained level. To this end, we propose a novel framework FineRec that explores the attribute-opinion pairs of reviews to finely handle sequential recommendation. Specifically, we utilize a large language model to extract attribute-opinion pairs from reviews. For each attribute, a unique attribute-specific user-opinion-item graph is created, where corresponding opinions serve as the edges linking heterogeneous user and item nodes. To tackle the diversity of opinions, we devise a diversity-aware convolution operation to aggregate information within the graphs, enabling attribute-specific user and item representation learning. Ultimately, we present an interaction-driven fusion mechanism to integrate attribute-specific user/item representations across all attributes for generating recommendations. Extensive experiments conducted on several realworld datasets demonstrate the superiority of our FineRec over existing state-of-the-art methods. Further analysis also verifies the effectiveness of our fine-grained manner in handling the task.

8.1IRApr 19, 2024Code
Disentangling ID and Modality Effects for Session-based Recommendation

Xiaokun Zhang, Bo Xu, Zhaochun Ren et al.

Session-based recommendation aims to predict intents of anonymous users based on their limited behaviors. Modeling user behaviors involves two distinct rationales: co-occurrence patterns reflected by item IDs, and fine-grained preferences represented by item modalities (e.g., text and images). However, existing methods typically entangle these causes, leading to their failure in achieving accurate and explainable recommendations. To this end, we propose a novel framework DIMO to disentangle the effects of ID and modality in the task. At the item level, we introduce a co-occurrence representation schema to explicitly incorporate cooccurrence patterns into ID representations. Simultaneously, DIMO aligns different modalities into a unified semantic space to represent them uniformly. At the session level, we present a multi-view self-supervised disentanglement, including proxy mechanism and counterfactual inference, to disentangle ID and modality effects without supervised signals. Leveraging these disentangled causes, DIMO provides recommendations via causal inference and further creates two templates for generating explanations. Extensive experiments on multiple real-world datasets demonstrate the consistent superiority of DIMO over existing methods. Further analysis also confirms DIMO's effectiveness in generating explanations.

4.8CLApr 23, 2024
Enhancing Textual Personality Detection toward Social Media: Integrating Long-term and Short-term Perspectives

Haohao Zhu, Xiaokun Zhang, Junyu Lu et al.

Textual personality detection aims to identify personality characteristics by analyzing user-generated content on social media platforms. Extensive psychological literature highlights that personality encompasses both long-term stable traits and short-term dynamic states. However, existing studies often concentrate only on either long-term or short-term personality representations, neglecting the integration of both aspects. This limitation hinders a comprehensive understanding of individuals' personalities, as both stable traits and dynamic states are vital. To bridge this gap, we propose a Dual Enhanced Network (DEN) to jointly model users' long-term and short-term personality traits. In DEN, the Long-term Personality Encoding module models stable long-term personality traits by analyzing consistent patterns in the usage of psychological entities. The Short-term Personality Encoding module captures dynamic short-term personality states by modeling the contextual information of individual posts in real-time. The Bi-directional Interaction module integrates both aspects of personality, creating a cohesive and comprehensive representation of the user's personality. Experimental results on two personality detection datasets demonstrate the effectiveness of the DEN model and underscore the importance of considering both stable and dynamic aspects of personality in textual personality detection.

4.9CLApr 10, 2025Code
Efficient Tuning of Large Language Models for Knowledge-Grounded Dialogue Generation

Bo Zhang, Hui Ma, Dailin Li et al.

Large language models (LLMs) demonstrate remarkable text comprehension and generation capabilities but often lack the ability to utilize up-to-date or domain-specific knowledge not included in their training data. To address this gap, we introduce KEDiT, an efficient method for fine-tuning LLMs for knowledge-grounded dialogue generation. KEDiT operates in two main phases: first, it employs an information bottleneck to compress retrieved knowledge into learnable parameters, retaining essential information while minimizing computational overhead. Second, a lightweight knowledge-aware adapter integrates these compressed knowledge vectors into the LLM during fine-tuning, updating less than 2\% of the model parameters. The experimental results on the Wizard of Wikipedia and a newly constructed PubMed-Dialog dataset demonstrate that KEDiT excels in generating contextually relevant and informative responses, outperforming competitive baselines in automatic, LLM-based, and human evaluations. This approach effectively combines the strengths of pretrained LLMs with the adaptability needed for incorporating dynamic knowledge, presenting a scalable solution for fields such as medicine.

3.6CVMar 25, 2025
VisualQuest: A Diverse Image Dataset for Evaluating Visual Recognition in LLMs

Kelaiti Xiao, Liang Yang, Paerhati Tulajiang et al.

This paper introduces VisualQuest, a novel image dataset designed to assess the ability of large language models (LLMs) to interpret non-traditional, stylized imagery. Unlike conventional photographic benchmarks, VisualQuest challenges models with images that incorporate abstract, symbolic, and metaphorical elements, requiring the integration of domain-specific knowledge and advanced reasoning. The dataset was meticulously curated through multiple stages of filtering, annotation, and standardization to ensure high quality and diversity. Our evaluations using several state-of-the-art multimodal LLMs reveal significant performance variations that underscore the importance of both factual background knowledge and inferential capabilities in visual recognition tasks. VisualQuest thus provides a robust and comprehensive benchmark for advancing research in multimodal reasoning and model architecture design.

1.9CLJun 18, 2024Code
IPEval: A Bilingual Intellectual Property Agency Consultation Evaluation Benchmark for Large Language Models

Qiyao Wang, Jianguo Huang, Shule Lu et al.

The rapid development of Large Language Models (LLMs) in vertical domains, including intellectual property (IP), lacks a specific evaluation benchmark for assessing their understanding, application, and reasoning abilities. To fill this gap, we introduce IPEval, the first evaluation benchmark tailored for IP agency and consulting tasks. IPEval comprises 2657 multiple-choice questions across four major dimensions: creation, application, protection, and management of IP. These questions span patent rights (inventions, utility models, designs), trademarks, copyrights, trade secrets, and other related laws. Evaluation methods include zero-shot, 5-few-shot, and Chain of Thought (CoT) for seven LLM types, predominantly in English or Chinese. Results show superior English performance by models like GPT series and Qwen series, while Chinese-centric LLMs excel in Chinese tests, albeit specialized IP LLMs lag behind general-purpose ones. Regional and temporal aspects of IP underscore the need for LLMs to grasp legal nuances and evolving laws. IPEval aims to accurately gauge LLM capabilities in IP and spur development of specialized models. Website: \url{https://ipeval.github.io/}

24.0CLJun 3, 2024Code
Take its Essence, Discard its Dross! Debiasing for Toxic Language Detection via Counterfactual Causal Effect

Junyu Lu, Bo Xu, Xiaokun Zhang et al.

Current methods of toxic language detection (TLD) typically rely on specific tokens to conduct decisions, which makes them suffer from lexical bias, leading to inferior performance and generalization. Lexical bias has both "useful" and "misleading" impacts on understanding toxicity. Unfortunately, instead of distinguishing between these impacts, current debiasing methods typically eliminate them indiscriminately, resulting in a degradation in the detection accuracy of the model. To this end, we propose a Counterfactual Causal Debiasing Framework (CCDF) to mitigate lexical bias in TLD. It preserves the "useful impact" of lexical bias and eliminates the "misleading impact". Specifically, we first represent the total effect of the original sentence and biased tokens on decisions from a causal view. We then conduct counterfactual inference to exclude the direct causal effect of lexical bias from the total effect. Empirical evaluations demonstrate that the debiased TLD model incorporating CCDF achieves state-of-the-art performance in both accuracy and fairness compared to competitive baselines applied on several vanilla models. The generalization capability of our model outperforms current debiased models for out-of-distribution data.

27.8CLMay 8, 2023Code
Facilitating Fine-grained Detection of Chinese Toxic Language: Hierarchical Taxonomy, Resources, and Benchmarks

Junyu Lu, Bo Xu, Xiaokun Zhang et al.

The widespread dissemination of toxic online posts is increasingly damaging to society. However, research on detecting toxic language in Chinese has lagged significantly. Existing datasets lack fine-grained annotation of toxic types and expressions, and ignore the samples with indirect toxicity. In addition, it is crucial to introduce lexical knowledge to detect the toxicity of posts, which has been a challenge for researchers. In this paper, we facilitate the fine-grained detection of Chinese toxic language. First, we built Monitor Toxic Frame, a hierarchical taxonomy to analyze toxic types and expressions. Then, a fine-grained dataset ToxiCN is presented, including both direct and indirect toxic samples. We also build an insult lexicon containing implicit profanity and propose Toxic Knowledge Enhancement (TKE) as a benchmark, incorporating the lexical feature to detect toxic language. In the experimental stage, we demonstrate the effectiveness of TKE. After that, a systematic quantitative and qualitative analysis of the findings is given.

2.6CLSep 3, 2020Code
Biomedical named entity recognition using BERT in the machine reading comprehension framework

Cong Sun, Zhihao Yang, Lei Wang et al.

Recognition of biomedical entities from literature is a challenging research focus, which is the foundation for extracting a large amount of biomedical knowledge existing in unstructured texts into structured formats. Using the sequence labeling framework to implement biomedical named entity recognition (BioNER) is currently a conventional method. This method, however, often cannot take full advantage of the semantic information in the dataset, and the performance is not always satisfactory. In this work, instead of treating the BioNER task as a sequence labeling problem, we formulate it as a machine reading comprehension (MRC) problem. This formulation can introduce more prior knowledge utilizing well-designed queries, and no longer need decoding processes such as conditional random fields (CRF). We conduct experiments on six BioNER datasets, and the experimental results demonstrate the effectiveness of our method. Our method achieves state-of-the-art (SOTA) performance on the BC4CHEMD, BC5CDR-Chem, BC5CDR-Disease, NCBI-Disease, BC2GM and JNLPBA datasets, achieving F1-scores of 92.92%, 94.19%, 87.83%, 90.04%, 85.48% and 78.93%, respectively.