Tianyu Wu

Mostafa Karimi, Changliang Liu, Kenichi Kumatani et al.

Self-supervised learning (SSL) methods have proven to be very successful in automatic speech recognition (ASR). These great improvements have been reported mostly based on highly curated datasets such as LibriSpeech for non-streaming End-to-End ASR models. However, the pivotal characteristics of SSL is to be utilized for any untranscribed audio data. In this paper, we provide a full exploration on how to utilize uncurated audio data in SSL from data pre-processing to deploying an streaming hybrid ASR model. More specifically, we present (1) the effect of Audio Event Detection (AED) model in data pre-processing pipeline (2) analysis on choosing optimizer and learning rate scheduling (3) comparison of recently developed contrastive losses, (4) comparison of various pre-training strategies such as utilization of in-domain versus out-domain pre-training data, monolingual versus multilingual pre-training data, multi-head multilingual SSL versus single-head multilingual SSL and supervised pre-training versus SSL. The experimental results show that SSL pre-training with in-domain uncurated data can achieve better performance in comparison to all the alternative out-domain pre-training strategies.

Tianyu Wu, Yang Tang, Qiyu Sun et al.

In recent years, artificial intelligence has played an important role on accelerating the whole process of drug discovery. Various of molecular representation schemes of different modals (e.g. textual sequence or graph) are developed. By digitally encoding them, different chemical information can be learned through corresponding network structures. Molecular graphs and Simplified Molecular Input Line Entry System (SMILES) are popular means for molecular representation learning in current. Previous works have done attempts by combining both of them to solve the problem of specific information loss in single-modal representation on various tasks. To further fusing such multi-modal imformation, the correspondence between learned chemical feature from different representation should be considered. To realize this, we propose a novel framework of molecular joint representation learning via Multi-Modal information of SMILES and molecular Graphs, called MMSG. We improve the self-attention mechanism by introducing bond level graph representation as attention bias in Transformer to reinforce feature correspondence between multi-modal information. We further propose a Bidirectional Message Communication Graph Neural Network (BMC GNN) to strengthen the information flow aggregated from graphs for further combination. Numerous experiments on public property prediction datasets have demonstrated the effectiveness of our model.

Fang Wan, Guangyi Huang, Tianyu Wu et al.

We introduce asRoBallet, to the best of our knowledge, the first successful deployment of reinforcement learning (RL) on a humanoid ballbot hardware. Historically, ballbots have served as a canonical benchmark for underactuated and nonholonomic control, which are characterized by a reality gap in complex friction models for wheel-sphere-ground interactions. While current literature demonstrates successful handling of 3D balancing with LQR and MPC, transitioning to actual hardware for a humanoid ballbot using RL is currently hindered by critical gaps in contact modeling, actuator latency & jitter, and safe hardware exploration, and safe hardware exploration. This study proposes a high-fidelity MuJoCo simulation that explicitly models the discrete roller mechanics of ETH-type omni-wheels, thereby capturing parasitic vibrations and contact discontinuities that are previously ignored. We also developed a Friction-Aware Reinforcement Learning framework that achieves zero-shot Sim2Real transfer by mastering the coupled rolling, lateral, and torsional friction channels at the wheel-sphere and sphere-ground interfaces. We designed asRoBallet through subtractive reconfiguration, repurposing key components from an overconstrained quadruped and integrating them into a newly designed structural frame to achieve a robust research platform at low cost. We also developed a generalized iOS ecosystem that transforms consumer electronics into a low-latency interface, enabling a single operator to orchestrate expressive humanoid maneuvers via intuitive natural motion.

Wenzhou Lv, Tianyu Wu, Luolin Xiong et al.

Objective: The artificial pancreas (AP) has shown promising potential in achieving closed-loop glucose control for individuals with type 1 diabetes mellitus (T1DM). However, designing an effective control policy for the AP remains challenging due to the complex physiological processes, delayed insulin response, and inaccurate glucose measurements. While model predictive control (MPC) offers safety and stability through the dynamic model and safety constraints, it lacks individualization and is adversely affected by unannounced meals. Conversely, deep reinforcement learning (DRL) provides personalized and adaptive strategies but faces challenges with distribution shifts and substantial data requirements. Methods: We propose a hybrid control policy for the artificial pancreas (HyCPAP) to address the above challenges. HyCPAP combines an MPC policy with an ensemble DRL policy, leveraging the strengths of both policies while compensating for their respective limitations. To facilitate faster deployment of AP systems in real-world settings, we further incorporate meta-learning techniques into HyCPAP, leveraging previous experience and patient-shared knowledge to enable fast adaptation to new patients with limited available data. Results: We conduct extensive experiments using the FDA-accepted UVA/Padova T1DM simulator across three scenarios. Our approaches achieve the highest percentage of time spent in the desired euglycemic range and the lowest occurrences of hypoglycemia. Conclusion: The results clearly demonstrate the superiority of our methods for closed-loop glucose management in individuals with T1DM. Significance: The study presents novel control policies for AP systems, affirming the great potential of proposed methods for efficient closed-loop glucose control.

Tianyu Wu, Yang Tang

Antimicrobial resistance is one of the biggest health problem, especially in the current period of COVID-19 pandemic. Due to the unique membrane-destruction bactericidal mechanism, antimicrobial peptide-mimetic copolymers are paid more attention and it is urgent to find more potential candidates with broad-spectrum antibacterial efficacy and low toxicity. Artificial intelligence has shown significant performance on small molecule or biotech drugs, however, the higher-dimension of polymer space and the limited experimental data restrict the application of existing methods on copolymer design. Herein, we develop a universal random copolymer inverse design system via multi-model copolymer representation learning, knowledge distillation and reinforcement learning. Our system realize a high-precision antimicrobial activity prediction with few-shot data by extracting various chemical information from multi-modal copolymer representations. By pre-training a scaffold-decorator generative model via knowledge distillation, copolymer space are greatly contracted to the near space of existing data for exploration. Thus, our reinforcement learning algorithm can be adaptive for customized generation on specific scaffolds and requirements on property or structures. We apply our system on collected antimicrobial peptide-mimetic copolymers data, and we discover candidate copolymers with desired properties.

Rongxin Chen, Tianyu Wu, Bingbing Xu et al.

High-fidelity agent initialization is crucial for credible Agent-Based Modeling across diverse domains. A robust framework should be Topic-Adaptive, capturing macro-level joint distributions while ensuring micro-level individual rationality. Existing approaches fall into two categories: static data-based retrieval methods that fail to adapt to unseen topics absent from the data, and LLM-based generation methods that lack macro-level distribution awareness, resulting in inconsistencies between micro-level persona attributes and reality. To address these problems, we propose HAG, a Hierarchical Agent Generation framework that formalizes population generation as a two-stage decision process. Firstly, utilizing a World Knowledge Model to infer hierarchical conditional probabilities to construct the Topic-Adaptive Tree, achieving macro-level distribution alignment. Then, grounded real-world data, instantiation and agentic augmentation are carried out to ensure micro-level consistency. Given the lack of specialized evaluation, we establish a multi-domain benchmark and a comprehensive PACE evaluation framework. Extensive experiments show that HAG significantly outperforms representative baselines, reducing population alignment errors by an average of 37.7% and enhancing sociological consistency by 18.8%.

Hongwei Zheng, Weiqi Wu, Zhengjia Wang et al.

Conversational agents, such as ChatGPT and Doubao, have become essential daily assistants for billions of users. To further enhance engagement, these systems are evolving from passive responders to proactive companions. However, existing efforts focus on activation within ongoing dialogues, while overlooking a key real-world bottleneck. In the conversation initiation stage, users may have a vague need but no explicit query intent, creating a first-message barrier where the conversation holds before it begins. To overcome this, we introduce Conversation Starter Generation: generating personalized starters to guide users into conversation. However, unlike in-conversation stages where immediate context guides the response, initiation must operate in a cold-start moment without explicit user intent. To pioneer in this direction, we present IceBreaker that frames human ice-breaking as a two-step handshake: (i) evoke resonance via Resonance-Aware Interest Distillation from session summaries to capture trigger interests, and (ii) stimulate interaction via Interaction-Oriented Starter Generation, optimized with personalized preference alignment and a self-reinforced loop to maximize engagement. Online A/B tests on one of the world's largest conversational agent products show that IceBreaker improves user active days by +0.184% and click-through rate by +9.425%, and has been deployed in production.

Tianyu Wu, Yu Yao, Zhenting Qi et al.

Speculative decoding accelerates LLM inference by having a small drafter propose tokens that a larger target model verifies in parallel. Recent diffusion-based parallel drafters such as DFlash predict the full B-token block in one forward pass, enabling deeper drafters and longer accepted blocks. However, existing multi-token drafter objectives often use fixed position-dependent weighting schedules, such as head-dependent weights or block-position decays, which do not adapt as the positions limiting acceptance change during training. To address this, we derive per-position training weights from a differentiable surrogate of expected accepted draft length, matching the weight of each position to its log-probability gradient contribution. The resulting loss, D-PACE (Dynamic Position-Aware Cross-Entropy), shifts training signal toward positions that currently limit acceptance as the drafter improves. Across six benchmarks, two Qwen3-4B draft depths, two decoding temperatures, and two additional target models, D-PACE consistently improves both wall-clock speedup and average emitted length, with 2.3\% measured training-time overhead and no changes to the drafter architecture or inference procedure.

Tianyu Wu, Lin Zhu

Motivation: Generative models for protein backbone design have to simultaneously ensure geometric validity, sampling efficiency, and scalability to long sequences. However, most existing approaches rely on iterative refinement, quadratic attention mechanisms, or post-hoc geometry correction, leading to a persistent trade-off between computational efficiency and structural fidelity. Results: We present Physics-Informed Mamba (PI-Mamba), a generative model that enforces exact local covalent geometry by construction while enabling linear-time inference. PI-Mamba integrates a differentiable constraint-enforcement operator into a flow-matching framework and couples it with a Mamba-based state-space architecture. To improve optimisation stability and backbone realism, we introduce a spectral initialization derived from the Rouse polymer model and an auxiliary cis-proline awareness head. Across benchmark tasks, PI-Mamba achieves 0.0\% local geometry violations and high designability (scTM = $0.91\pm 0.03$, n = 100), while scaling to proteins exceeding 2,000 residues on a single A5000 GPU (24 GB).

Tianyu Wu, Konrad Schindler, Cenek Albl

We investigate the possibility of 3D scene reconstruction from two or more overlapping webcam streams. A large, and growing, number of webcams observe places of interest and are publicly accessible. The question naturally arises: can we make use of this free data source for 3D computer vision? It turns out that the task to reconstruct scene structure from webcam streams is very different from standard structure-from-motion (SfM), and conventional SfM pipelines fail. In the webcam setting there are very few views of the same scene, in most cases only the minimum of two. These viewpoints often have large baselines and/or scale differences, their overlap is rather limited, and besides unknown internal and external calibration also their temporal synchronisation is unknown. On the other hand, they record rather large fields of view continuously over long time spans, so that they regularly observe dynamic objects moving through the scene. We show how to leverage recent advances in several areas of computer vision to adapt SfM reconstruction to this particular scenario and reconstruct the unknown camera poses, the 3D scene structure, and the 3D trajectories of dynamic objects.

Manu Tom, Tianyu Wu, Emmanuel Baltsavias et al.

Depleting lake ice is a climate change indicator, just like sea-level rise or glacial retreat. Monitoring Lake Ice Phenology (LIP) is useful because long-term freezing and thawing patterns serve as sentinels to understand regional and global climate change. We report a study for the Oberengadin region of Switzerland, where several small- and medium-sized mountain lakes are located. We observe the LIP events, such as freeze-up, break-up and ice cover duration, across two decades (2000-2020) from optical satellite images. We analyse the time series of MODIS imagery by estimating spatially resolved maps of lake ice for these Alpine lakes with supervised machine learning. To train the classifier we rely on reference data annotated manually based on webcam images. From the ice maps, we derive long-term LIP trends. Since the webcam data are only available for two winters, we cross-check our results against the operational MODIS and VIIRS snow products. We find a change in complete freeze duration of -0.76 and -0.89 days per annum for lakes Sils and Silvaplana, respectively. Furthermore, we observe plausible correlations of the LIP trends with climate data measured at nearby meteorological stations. We notice that mean winter air temperature has a negative correlation with the freeze duration and break-up events and a positive correlation with the freeze-up events. Additionally, we observe a strong negative correlation of sunshine during the winter months with the freeze duration and break-up events.

Manu Tom, Rajanie Prabha, Tianyu Wu et al.

Continuous observation of climate indicators, such as trends in lake freezing, is important to understand the dynamics of the local and global climate system. Consequently, lake ice has been included among the Essential Climate Variables (ECVs) of the Global Climate Observing System (GCOS), and there is a need to set up operational monitoring capabilities. Multi-temporal satellite images and publicly available webcam streams are among the viable data sources to monitor lake ice. In this work we investigate machine learning-based image analysis as a tool to determine the spatio-temporal extent of ice on Swiss Alpine lakes as well as the ice-on and ice-off dates, from both multispectral optical satellite images (VIIRS and MODIS) and RGB webcam images. We model lake ice monitoring as a pixel-wise semantic segmentation problem, i.e., each pixel on the lake surface is classified to obtain a spatially explicit map of ice cover. We show experimentally that the proposed system produces consistently good results when tested on data from multiple winters and lakes. Our satellite-based method obtains mean Intersection-over-Union (mIoU) scores >93%, for both sensors. It also generalises well across lakes and winters with mIoU scores >78% and >80% respectively. On average, our webcam approach achieves mIoU values of 87% (approx.) and generalisation scores of 71% (approx.) and 69% (approx.) across different cameras and winters respectively. Additionally, we put forward a new benchmark dataset of webcam images (Photi-LakeIce) which includes data from two winters and three cameras.

Zhimin Peng, Tianyu Wu, Yangyang Xu et al.

This paper focuses on coordinate update methods, which are useful for solving problems involving large or high-dimensional datasets. They decompose a problem into simple subproblems, where each updates one, or a small block of, variables while fixing others. These methods can deal with linear and nonlinear mappings, smooth and nonsmooth functions, as well as convex and nonconvex problems. In addition, they are easy to parallelize. The great performance of coordinate update methods depends on solving simple sub-problems. To derive simple subproblems for several new classes of applications, this paper systematically studies coordinate-friendly operators that perform low-cost coordinate updates. Based on the discovered coordinate friendly operators, as well as operator splitting techniques, we obtain new coordinate update algorithms for a variety of problems in machine learning, image processing, as well as sub-areas of optimization. Several problems are treated with coordinate update for the first time in history. The obtained algorithms are scalable to large instances through parallel and even asynchronous computing. We present numerical examples to illustrate how effective these algorithms are.