Dominique Lavenier

William Andrew Simon, Leonid Yavits, Konstantina Koliogeorgi et al.

Low-cost, high-throughput DNA and RNA sequencing (HTS) data is the backbone of the life sciences. Genome sequencing is now becoming a part of Predictive, Preventive, Personalized, and Participatory (termed 'P4') medicine. All genomic data are currently processed in energy-hungry computer clusters and centers, necessitating data transfer, consuming substantial energy, and wasting valuable time. Therefore, there is a need for fast, energy-efficient, and cost-efficient technologies that enable genomics research without requiring data centers and cloud platforms. We recently launched the BioPIM Project to leverage emerging processing-in-memory (PIM) technologies to enable energy- and cost-efficient analysis of bioinformatics workloads. The BioPIM Project focuses on co-designing algorithms and data structures commonly used in genomics with several PIM architectures to achieve the highest cost, energy, and time savings.

Hoang Son Pham, Gwendal Virlet, Dominique Lavenier et al.

Discriminative pattern mining is an essential task of data mining. This task aims to discover patterns which occur more frequently in a class than other classes in a class-labeled dataset. This type of patterns is valuable in various domains such as bioinformatics, data classification. In this paper, we propose a novel algorithm, named SSDPS, to discover patterns in two-class datasets. The SSDPS algorithm owes its efficiency to an original enumeration strategy of the patterns, which allows to exploit some degrees of anti-monotonicity on the measures of discriminance and statistical significance. Experimental results demonstrate that the performance of the SSDPS algorithm is better than others. In addition, the number of generated patterns is much less than the number of other algorithms. Experiment on real data also shows that SSDPS efficiently detects multiple SNPs combinations in genetic data.