Matteo Polsinelli

Giuseppe Placidi, Luigi Cinque, Daniela Iacoviello et al.

To date, several automated strategies for identification/segmentation of Multiple Sclerosis (MS) lesions with the use of Magnetic Resonance Imaging (MRI) have been presented, but they are outperformed by human experts, from whom they act very differently. This is mainly due to: the ambiguity originated by MRI instabilities; peculiar variability of MS; non specificity of MRI regarding MS. Physicians partially manage the uncertainty generated by ambiguity relying on radiological/clinical/anatomical background and experience. To emulate human diagnosis, we present an automated framework for identification/segmentation of MS lesions from MRI based on three pivotal concepts: 1. the modelling of uncertainty; 2. the proposal of two, separately trained, CNN, one optimized for lesions and the other for lesions with respect to the environment surrounding them, respectively repeated for axial, coronal and sagittal directions; 3. the definition of an ensemble classifier to merge the information collected by different CNN. The proposed framework is trained, validated and tested on the 2016 MSSEG benchmark public data set from a single imaging modality, the FLuid-Attenuated Inversion Recovery (FLAIR). The comparison with the ground-truth and with each of 7 human raters, proves that there is no significant difference between the automated and the human raters.

Giuseppe Placidi, Luigi Cinque, Matteo Polsinelli

Electroencephalography (EEG) measures the electrical brain activity in real-time by using sensors placed on the scalp. Artifacts, due to eye movements and blink, muscular/cardiac activity and generic electrical disturbances, have to be recognized and eliminated to allow a correct interpretation of the useful brain signals (UBS) of EEG. Independent Component Analysis (ICA) is effective to split the signal into independent components (ICs) whose re-projections on 2D scalp topographies (images), also called topoplots, allow to recognize/separate artifacts and by UBS. Until now, IC topoplot analysis, a gold standard in EEG, has been carried on visually by human experts and, hence, not usable in automatic, fast-response EEG. We present a completely automatic and effective framework for EEG artifact recognition by IC topoplots, based on 2D Convolutional Neural Networks (CNNs), capable to divide topoplots in 4 classes: 3 types of artifacts and UBS. The framework setup is described and results are presented, discussed and compared with those obtained by other competitive strategies. Experiments, carried on public EEG datasets, have shown an overall accuracy of above 98%, employing 1.4 sec on a standard PC to classify 32 topoplots, that is to drive an EEG system of 32 sensors. Though not real-time, the proposed framework is efficient enough to be used in fast-response EEG-based Brain-Computer Interfaces (BCI) and faster than other automatic methods based on ICs.

Matteo Polsinelli, Luigi Cinque, Giuseppe Placidi

OVID-19 is a world-wide disease that has been declared as a pandemic by the World Health Organization. Computer Tomography (CT) imaging of the chest seems to be a valid diagnosis tool to detect COVID-19 promptly and to control the spread of the disease. Deep Learning has been extensively used in medical imaging and convolutional neural networks (CNNs) have been also used for classification of CT images. We propose a light CNN design based on the model of the SqueezeNet, for the efficient discrimination of COVID-19 CT images with other CT images (community-acquired pneumonia and/or healthy images). On the tested datasets, the proposed modified SqueezeNet CNN achieved 83.00\% of accuracy, 85.00\% of sensitivity, 81.00\% of specificity, 81.73\% of precision and 0.8333 of F1Score in a very efficient way (7.81 seconds medium-end laptot without GPU acceleration). Besides performance, the average classification time is very competitive with respect to more complex CNN designs, thus allowing its usability also on medium power computers. In the next future we aim at improving the performances of the method along two directions: 1) by increasing the training dataset (as soon as other CT images will be available); 2) by introducing an efficient pre-processing strategy.