Panos K. Chrysanthis

Jean-Daniel Fekete, Yifan Hu, Dominik Moritz et al.

The rapid advancement of AI is transforming human-centered systems, with profound implications for human-AI interaction, human-data interaction, and visual analytics. In the AI era, data analysis increasingly involves large-scale, heterogeneous, and multimodal data that is predominantly unstructured, as well as foundation models such as LLMs and VLMs, which introduce additional uncertainty into analytical processes. These shifts expose persistent challenges for human-data interactive systems, including perceptually misaligned latency, scalability constraints, limitations of existing interaction and exploration paradigms, and growing uncertainty regarding the reliability and interpretability of AI-generated insights. Responding to these challenges requires moving beyond conventional efficiency and scalability metrics, redefining the roles of humans and machines in analytical workflows, and incorporating cognitive, perceptual, and design principles into every level of the human-data interaction stack. This paper investigates the challenges introduced by recent advances in AI and examines how these developments are reshaping the ways users engage with data, while outlining limitations and open research directions for building human-centered AI systems for interactive data analysis in the AI era.

Vineet K Raghu, Xiaoyu Ge, Arun Balajee et al.

High throughput genome sequencing technologies such as RNA-Seq and Microarray have the potential to transform clinical decision making and biomedical research by enabling high-throughput measurements of the genome at a granular level. However, to truly understand causes of disease and the effects of medical interventions, this data must be integrated with phenotypic, environmental, and behavioral data from individuals. Further, effective knowledge discovery methods that can infer relationships between these data types are required. In this work, we propose a pipeline for knowledge discovery from integrated genomic and clinical data. The pipeline begins with a novel variable selection method, and uses a probabilistic graphical model to understand the relationships between features in the data. We demonstrate how this pipeline can improve breast cancer outcome prediction models, and can provide a biologically interpretable view of sequencing data.