Xin Guo

Xin Guo, Jiangwei Lao, Bo Dang et al.

Prior studies on Remote Sensing Foundation Model (RSFM) reveal immense potential towards a generic model for Earth Observation. Nevertheless, these works primarily focus on a single modality without temporal and geo-context modeling, hampering their capabilities for diverse tasks. In this study, we present SkySense, a generic billion-scale model, pre-trained on a curated multi-modal Remote Sensing Imagery (RSI) dataset with 21.5 million temporal sequences. SkySense incorporates a factorized multi-modal spatiotemporal encoder taking temporal sequences of optical and Synthetic Aperture Radar (SAR) data as input. This encoder is pre-trained by our proposed Multi-Granularity Contrastive Learning to learn representations across different modal and spatial granularities. To further enhance the RSI representations by the geo-context clue, we introduce Geo-Context Prototype Learning to learn region-aware prototypes upon RSI's multi-modal spatiotemporal features. To our best knowledge, SkySense is the largest Multi-Modal RSFM to date, whose modules can be flexibly combined or used individually to accommodate various tasks. It demonstrates remarkable generalization capabilities on a thorough evaluation encompassing 16 datasets over 7 tasks, from single- to multi-modal, static to temporal, and classification to localization. SkySense surpasses 18 recent RSFMs in all test scenarios. Specifically, it outperforms the latest models such as GFM, SatLas and Scale-MAE by a large margin, i.e., 2.76%, 3.67% and 3.61% on average respectively. We will release the pre-trained weights to facilitate future research and Earth Observation applications.

Min Zhao, Xin Guo, Le Song et al.

The environment of most real-world scenarios such as malls and supermarkets changes at all times. A pre-built map that does not account for these changes becomes out-of-date easily. Therefore, it is necessary to have an up-to-date model of the environment to facilitate long-term operation of a robot. To this end, this paper presents a general lifelong simultaneous localization and mapping (SLAM) framework. Our framework uses a multiple session map representation, and exploits an efficient map updating strategy that includes map building, pose graph refinement and sparsification. To mitigate the unbounded increase of memory usage, we propose a map-trimming method based on the Chow-Liu maximum-mutual-information spanning tree. The proposed SLAM framework has been comprehensively validated by over a month of robot deployment in real supermarket environment. Furthermore, we release the dataset collected from the indoor and outdoor changing environment with the hope to accelerate lifelong SLAM research in the community. Our dataset is available at https://github.com/sanduan168/lifelong-SLAM-dataset.

Changchun Yang, Haoyang Li, Yushuai Wu et al.

While pathology foundation models have transformed cancer image analysis, they often lack integration with molecular data at single-cell resolution, limiting their utility for precision oncology. Here, we present PAST, a pan-cancer single-cell foundation model trained on 20 million paired histopathology images and single-cell transcriptomes spanning multiple tumor types and tissue contexts. By jointly encoding cellular morphology and gene expression, PAST learns unified cross-modal representations that capture both spatial and molecular heterogeneity at the cellular level. This approach enables accurate prediction of single-cell gene expression, virtual molecular staining, and multimodal survival analysis directly from routine pathology slides. Across diverse cancers and downstream tasks, PAST consistently exceeds the performance of existing approaches, demonstrating robust generalizability and scalability. Our work establishes a new paradigm for pathology foundation models, providing a versatile tool for high-resolution spatial omics, mechanistic discovery, and precision cancer research.

Yifeng Jiao, Yuchen Liu, Yu Zhang et al.

The advent of single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) offers an innovative perspective for deciphering regulatory mechanisms by assembling a vast repository of single-cell chromatin accessibility data. While foundation models have achieved significant success in single-cell transcriptomics, there is currently no foundation model for scATAC-seq that supports zero-shot high-quality cell identification and comprehensive multi-omics analysis simultaneously. Key challenges lie in the high dimensionality and sparsity of scATAC-seq data, as well as the lack of a standardized schema for representing open chromatin regions (OCRs). Here, we present ChromFound, a foundation model tailored for scATAC-seq. ChromFound utilizes a hybrid architecture and genome-aware tokenization to effectively capture genome-wide long contexts and regulatory signals from dynamic chromatin landscapes. Pretrained on 1.97 million cells from 30 tissues and 6 disease conditions, ChromFound demonstrates broad applicability across 6 diverse tasks. Notably, it achieves robust zero-shot performance in generating universal cell representations and exhibits excellent transferability in cell type annotation and cross-omics prediction. By uncovering enhancer-gene links undetected by existing computational methods, ChromFound offers a promising framework for understanding disease risk variants in the noncoding genome.

Xin Guo, Xinyu Li, Chinmay Maheshwari et al.

We propose a new framework of Markov $α$-potential games to study Markov games. We show that any Markov game with finite-state and finite-action is a Markov $α$-potential game, and establish the existence of an associated $α$-potential function. Any optimizer of an $α$-potential function is shown to be an $α$-stationary Nash equilibrium. We study two important classes of practically significant Markov games, Markov congestion games and the perturbed Markov team games, via the framework of Markov $α$-potential games, with explicit characterization of an upper bound for $α$ and its relation to game parameters. Additionally, we provide a semi-infinite linear programming based formulation to obtain an upper bound for $α$ for any Markov game. Furthermore, we study two equilibrium approximation algorithms, namely the projected gradient-ascent algorithm and the sequential maximum improvement algorithm, along with their Nash regret analysis, and corroborate the results with numerical experiments.

Xin Guo, Binnan Wang, Ruixun Zhang et al.

Signatures are iterated path integrals of continuous and discrete-time processes, and their universal nonlinearity linearizes the problem of feature selection in time series data analysis. This paper studies the consistency of signature using Lasso regression, both theoretically and numerically. We establish conditions under which the Lasso regression is consistent both asymptotically and in finite sample. Furthermore, we show that the Lasso regression is more consistent with the Itô signature for time series and processes that are closer to the Brownian motion and with weaker inter-dimensional correlations, while it is more consistent with the Stratonovich signature for mean-reverting time series and processes. We demonstrate that signature can be applied to learn nonlinear functions and option prices with high accuracy, and the performance depends on properties of the underlying process and the choice of the signature.

Xin Guo, Anran Hu, Junzi Zhang

When designing algorithms for finite-time-horizon episodic reinforcement learning problems, a common approach is to introduce a fictitious discount factor and use stationary policies for approximations. Empirically, it has been shown that the fictitious discount factor helps reduce variance, and stationary policies serve to save the per-iteration computational cost. Theoretically, however, there is no existing work on convergence analysis for algorithms with this fictitious discount recipe. This paper takes the first step towards analyzing these algorithms. It focuses on two vanilla policy gradient (VPG) variants: the first being a widely used variant with discounted advantage estimations (DAE), the second with an additional fictitious discount factor in the score functions of the policy gradient estimators. Non-asymptotic convergence guarantees are established for both algorithms, and the additional discount factor is shown to reduce the bias introduced in DAE and thus improve the algorithm convergence asymptotically. A key ingredient of our analysis is to connect three settings of Markov decision processes (MDPs): the finite-time-horizon, the average reward and the discounted settings. To our best knowledge, this is the first theoretical guarantee on fictitious discount algorithms for the episodic reinforcement learning of finite-time-horizon MDPs, which also leads to the (first) global convergence of policy gradient methods for finite-time-horizon episodic reinforcement learning.

Haotian Gu, Xin Guo, Xinyu Li

Adversarial training has gained great popularity as one of the most effective defenses for deep neural network and more generally for gradient-based machine learning models against adversarial perturbations on data points. This paper establishes a continuous-time approximation for the mini-max game of adversarial training. This approximation approach allows for precise and analytical comparisons between stochastic gradient descent and its adversarial training counterpart; and confirms theoretically the robustness of adversarial training from a new gradient-flow viewpoint. The analysis is then corroborated through various analytical and numerical examples.

Xin Guo, Jiequn Han, Mahan Tajrobehkar et al.

Motivated by the super-diffusivity of self-repelling random walk, which has roots in statistical physics, this paper develops a new perturbation mechanism for optimization algorithms. In this mechanism, perturbations are adapted to the history of states via the notion of occupation time. After integrating this mechanism into the framework of perturbed gradient descent (PGD) and perturbed accelerated gradient descent (PAGD), two new algorithms are proposed: perturbed gradient descent adapted to occupation time (PGDOT) and its accelerated version (PAGDOT). PGDOT and PAGDOT are shown to converge to second-order stationary points at least as fast as PGD and PAGD, respectively, and thus they are guaranteed to avoid getting stuck at non-degenerate saddle points. The theoretical analysis is corroborated by empirical studies in which the new algorithms consistently escape saddle points and outperform not only their counterparts, PGD and PAGD, but also other popular alternatives including stochastic gradient descent, Adam, AMSGrad, and RMSProp.