INS-DETJan 4, 2021
A new solution to the curved Ewald sphere problem for 3D image reconstruction in electron microscopyJ. P. J. Chen, K. E. Schmidt, J. C. H. Spence et al.
We develop an algorithm capable of imaging a three-dimensional object given a collection of two-dimensional images of that object that are significantly influenced by the curvature of the Ewald sphere. These two-dimensional images cannot be approximated as projections of the object. Such an algorithm is useful in cryo-electron microscopy where larger samples, higher resolution, or lower energy electron beams are desired, all of which contribute to the significance of Ewald curvature.