Sheng Xu

Yanjing Li, Sheng Xu, Baochang Zhang et al.

The large pre-trained vision transformers (ViTs) have demonstrated remarkable performance on various visual tasks, but suffer from expensive computational and memory cost problems when deployed on resource-constrained devices. Among the powerful compression approaches, quantization extremely reduces the computation and memory consumption by low-bit parameters and bit-wise operations. However, low-bit ViTs remain largely unexplored and usually suffer from a significant performance drop compared with the real-valued counterparts. In this work, through extensive empirical analysis, we first identify the bottleneck for severe performance drop comes from the information distortion of the low-bit quantized self-attention map. We then develop an information rectification module (IRM) and a distribution guided distillation (DGD) scheme for fully quantized vision transformers (Q-ViT) to effectively eliminate such distortion, leading to a fully quantized ViTs. We evaluate our methods on popular DeiT and Swin backbones. Extensive experimental results show that our method achieves a much better performance than the prior arts. For example, our Q-ViT can theoretically accelerates the ViT-S by 6.14x and achieves about 80.9% Top-1 accuracy, even surpassing the full-precision counterpart by 1.0% on ImageNet dataset. Our codes and models are attached on https://github.com/YanjingLi0202/Q-ViT

Sheng Xu, Yanjing Li, Teli Ma et al.

Binary neural networks (BNNs) have received ever-increasing popularity for their great capability of reducing storage burden as well as quickening inference time. However, there is a severe performance drop compared with real-valued networks, due to its intrinsic frequent weight oscillation during training. In this paper, we introduce a Resilient Binary Neural Network (ReBNN) to mitigate the frequent oscillation for better BNNs' training. We identify that the weight oscillation mainly stems from the non-parametric scaling factor. To address this issue, we propose to parameterize the scaling factor and introduce a weighted reconstruction loss to build an adaptive training objective. For the first time, we show that the weight oscillation is controlled by the balanced parameter attached to the reconstruction loss, which provides a theoretical foundation to parameterize it in back propagation. Based on this, we learn our ReBNN by calculating the balanced parameter based on its maximum magnitude, which can effectively mitigate the weight oscillation with a resilient training process. Extensive experiments are conducted upon various network models, such as ResNet and Faster-RCNN for computer vision, as well as BERT for natural language processing. The results demonstrate the overwhelming performance of our ReBNN over prior arts. For example, our ReBNN achieves 66.9% Top-1 accuracy with ResNet-18 backbone on the ImageNet dataset, surpassing existing state-of-the-arts by a significant margin. Our code is open-sourced at https://github.com/SteveTsui/ReBNN.

Sheng Xu, Yanjing Li, Bohan Zeng et al.

Knowledge distillation (KD) has been proven to be useful for training compact object detection models. However, we observe that KD is often effective when the teacher model and student counterpart share similar proposal information. This explains why existing KD methods are less effective for 1-bit detectors, caused by a significant information discrepancy between the real-valued teacher and the 1-bit student. This paper presents an Information Discrepancy-aware strategy (IDa-Det) to distill 1-bit detectors that can effectively eliminate information discrepancies and significantly reduce the performance gap between a 1-bit detector and its real-valued counterpart. We formulate the distillation process as a bi-level optimization formulation. At the inner level, we select the representative proposals with maximum information discrepancy. We then introduce a novel entropy distillation loss to reduce the disparity based on the selected proposals. Extensive experiments demonstrate IDa-Det's superiority over state-of-the-art 1-bit detectors and KD methods on both PASCAL VOC and COCO datasets. IDa-Det achieves a 76.9% mAP for a 1-bit Faster-RCNN with ResNet-18 backbone. Our code is open-sourced on https://github.com/SteveTsui/IDa-Det.

Sheng Xu, Yanjing Li, Tiancheng Wang et al.

Binary Neural Networks (BNNs) show great promise for real-world embedded devices. As one of the critical steps to achieve a powerful BNN, the scale factor calculation plays an essential role in reducing the performance gap to their real-valued counterparts. However, existing BNNs neglect the intrinsic bilinear relationship of real-valued weights and scale factors, resulting in a sub-optimal model caused by an insufficient training process. To address this issue, Recurrent Bilinear Optimization is proposed to improve the learning process of BNNs (RBONNs) by associating the intrinsic bilinear variables in the back propagation process. Our work is the first attempt to optimize BNNs from the bilinear perspective. Specifically, we employ a recurrent optimization and Density-ReLU to sequentially backtrack the sparse real-valued weight filters, which will be sufficiently trained and reach their performance limits based on a controllable learning process. We obtain robust RBONNs, which show impressive performance over state-of-the-art BNNs on various models and datasets. Particularly, on the task of object detection, RBONNs have great generalization performance. Our code is open-sourced on https://github.com/SteveTsui/RBONN .

Sicheng Gao, Xuhui Liu, Bohan Zeng et al.

Image super-resolution (SR) has attracted increasing attention due to its wide applications. However, current SR methods generally suffer from over-smoothing and artifacts, and most work only with fixed magnifications. This paper introduces an Implicit Diffusion Model (IDM) for high-fidelity continuous image super-resolution. IDM integrates an implicit neural representation and a denoising diffusion model in a unified end-to-end framework, where the implicit neural representation is adopted in the decoding process to learn continuous-resolution representation. Furthermore, we design a scale-controllable conditioning mechanism that consists of a low-resolution (LR) conditioning network and a scaling factor. The scaling factor regulates the resolution and accordingly modulates the proportion of the LR information and generated features in the final output, which enables the model to accommodate the continuous-resolution requirement. Extensive experiments validate the effectiveness of our IDM and demonstrate its superior performance over prior arts.

Chengbin Hou, Xinyu Lin, Hanhui Huang et al.

Identification of fossil species is crucial to evolutionary studies. Recent advances from deep learning have shown promising prospects in fossil image identification. However, the quantity and quality of labeled fossil images are often limited due to fossil preservation, conditioned sampling, and expensive and inconsistent label annotation by domain experts, which pose great challenges to training deep learning based image classification models. To address these challenges, we follow the idea of the wisdom of crowds and propose a multiview ensemble framework, which collects Original (O), Gray (G), and Skeleton (S) views of each fossil image reflecting its different characteristics to train multiple base models, and then makes the final decision via soft voting. Experiments on the largest fusulinid dataset with 2400 images show that the proposed OGS consistently outperforms baselines (using a single model for each view), and obtains superior or comparable performance compared to OOO (using three base models for three the same Original views). Besides, as the training data decreases, the proposed framework achieves more gains. While considering the identification consistency estimation with respect to human experts, OGS receives the highest agreement with the original labels of dataset and with the re-identifications of two human experts. The validation performance provides a quantitative estimation of consistency across different experts and genera. We conclude that the proposed framework can present state-of-the-art performance in the fusulinid fossil identification case study. This framework is designed for general fossil identification and it is expected to see applications to other fossil datasets in future work. The source code is publicly available at https://github.com/houchengbin/Fossil-Image-Identification to benefit future research in fossil image identification.

Huayi Zhou, Wei Gao, Dekun Lu et al.

End-to-end manipulation policies, combined with web-scale pretrained Vision-Language Models (VLMs), show the promise for generalizable and dexterous robotic manipulation. However, they inherit two key limitations from 2D foundation models: 1) the reliance on 2D RGB inputs that ignores the intrinsically 3D nature of manipulation; and 2) the lack of spatial 3D alignment between input-output spaces as well as across diverse robot embodiments, camera setups, and trajectory datasets. In this paper, we present a series of contributions to address these issues. First, we introduce aligned vertex map and vertex spectrum -- a pixel-wise 3D representation that elevates 2D visual inputs to 3D, using camera calibration and optional depth. This novel input representation marries 3D awareness with the generalization of 2D large VLMs. Then, we propose to align the inputs and outputs of manipulation policies by expressing per-pixel 3D information of each camera view and robot actions to a shared coordinate. Based on this, we designate a canonical Bird's-Eye-View (BEV) alignment frame and innovatively propose to construct BEV images, producing a view-invariant representation robust to camera pose variations. To enable training and evaluation at scale, we develop a comprehensive data processing pipeline to perform such alignments; we also introduce a novel temporal alignment scheme for trajectories across diverse robots, human operators, and datasets. These contributions collectively mitigate input and output spatial-temporal misalignments, improving the consistency and generalization for real-world manipulation. Pretrained checkpoint, source code and data processing pipeline are available in https://hnuzhy.github.io/projects/Dex-BEV.

Sheng Xu, Yanjing Li, Mingbao Lin et al.

The recent detection transformer (DETR) has advanced object detection, but its application on resource-constrained devices requires massive computation and memory resources. Quantization stands out as a solution by representing the network in low-bit parameters and operations. However, there is a significant performance drop when performing low-bit quantized DETR (Q-DETR) with existing quantization methods. We find that the bottlenecks of Q-DETR come from the query information distortion through our empirical analyses. This paper addresses this problem based on a distribution rectification distillation (DRD). We formulate our DRD as a bi-level optimization problem, which can be derived by generalizing the information bottleneck (IB) principle to the learning of Q-DETR. At the inner level, we conduct a distribution alignment for the queries to maximize the self-information entropy. At the upper level, we introduce a new foreground-aware query matching scheme to effectively transfer the teacher information to distillation-desired features to minimize the conditional information entropy. Extensive experimental results show that our method performs much better than prior arts. For example, the 4-bit Q-DETR can theoretically accelerate DETR with ResNet-50 backbone by 6.6x and achieve 39.4% AP, with only 2.6% performance gaps than its real-valued counterpart on the COCO dataset.

Guiliang Liu, Sheng Xu, Shicheng Liu et al.

Inverse Constrained Reinforcement Learning (ICRL) is the task of inferring the implicit constraints that expert agents adhere to, based on their demonstration data. As an emerging research topic, ICRL has received considerable attention in recent years. This article presents a categorical survey of the latest advances in ICRL. It serves as a comprehensive reference for machine learning researchers and practitioners, as well as starters seeking to comprehend the definitions, advancements, and important challenges in ICRL. We begin by formally defining the problem and outlining the algorithmic framework that facilitates constraint inference across various scenarios. These include deterministic or stochastic environments, environments with limited demonstrations, and multiple agents. For each context, we illustrate the critical challenges and introduce a series of fundamental methods to tackle these issues. This survey encompasses discrete, virtual, and realistic environments for evaluating ICRL agents. We also delve into the most pertinent applications of ICRL, such as autonomous driving, robot control, and sports analytics. To stimulate continuing research, we conclude the survey with a discussion of key unresolved questions in ICRL that can effectively foster a bridge between theoretical understanding and practical industrial applications. The papers referenced in this survey can be found at https://github.com/Jasonxu1225/Awesome-Constraint-Inference-in-RL.

Ang He, Xiaobo Li, Ximei Wu et al.

Unmanned aerial vehicles (UAVs) equipped with thermal infrared (TIR) cameras play a crucial role in combating nocturnal wildlife poaching. However, TIR images often face challenges such as jitter, and wildlife overlap, necessitating UAVs to possess the capability to identify blurred and overlapping small targets. Current traditional lightweight networks deployed on UAVs struggle to extract features from blurry small targets. To address this issue, we developed ALSS-YOLO, an efficient and lightweight detector optimized for TIR aerial images. Firstly, we propose a novel Adaptive Lightweight Channel Split and Shuffling (ALSS) module. This module employs an adaptive channel split strategy to optimize feature extraction and integrates a channel shuffling mechanism to enhance information exchange between channels. This improves the extraction of blurry features, crucial for handling jitter-induced blur and overlapping targets. Secondly, we developed a Lightweight Coordinate Attention (LCA) module that employs adaptive pooling and grouped convolution to integrate feature information across dimensions. This module ensures lightweight operation while maintaining high detection precision and robustness against jitter and target overlap. Additionally, we developed a single-channel focus module to aggregate the width and height information of each channel into four-dimensional channel fusion, which improves the feature representation efficiency of infrared images. Finally, we modify the localization loss function to emphasize the loss value associated with small objects to improve localization accuracy. Extensive experiments on the BIRDSAI and ISOD TIR UAV wildlife datasets show that ALSS-YOLO achieves state-of-the-art performance, Our code is openly available at https://github.com/helloworlder8/computer_vision.

Xinrui Song, Xuanang Xu, Sheng Xu et al.

In this work, we propose to explicitly use the landmarks of prostate to guide the MR-TRUS image registration. We first train a deep neural network to automatically localize a set of meaningful landmarks, and then directly generate the affine registration matrix from the location of these landmarks. For landmark localization, instead of directly training a network to predict the landmark coordinates, we propose to regress a full-resolution distance map of the landmark, which is demonstrated effective in avoiding statistical bias to unsatisfactory performance and thus improving performance. We then use the predicted landmarks to generate the affine transformation matrix, which outperforms the clinicians' manual rigid registration by a significant margin in terms of TRE.

Yanjing Li, Sheng Xu, Mingbao Lin et al.

In this paper, we focus on developing knowledge distillation (KD) for compact 3D detectors. We observe that off-the-shelf KD methods manifest their efficacy only when the teacher model and student counterpart share similar intermediate feature representations. This might explain why they are less effective in building extreme-compact 3D detectors where significant representation disparity arises due primarily to the intrinsic sparsity and irregularity in 3D point clouds. This paper presents a novel representation disparity-aware distillation (RDD) method to address the representation disparity issue and reduce performance gap between compact students and over-parameterized teachers. This is accomplished by building our RDD from an innovative perspective of information bottleneck (IB), which can effectively minimize the disparity of proposal region pairs from student and teacher in features and logits. Extensive experiments are performed to demonstrate the superiority of our RDD over existing KD methods. For example, our RDD increases mAP of CP-Voxel-S to 57.1% on nuScenes dataset, which even surpasses teacher performance while taking up only 42% FLOPs.

Yanjing Li, Sheng Xu, Xianbin Cao et al.

Neural architecture search (NAS) proves to be among the effective approaches for many tasks by generating an application-adaptive neural architecture, which is still challenged by high computational cost and memory consumption. At the same time, 1-bit convolutional neural networks (CNNs) with binary weights and activations show their potential for resource-limited embedded devices. One natural approach is to use 1-bit CNNs to reduce the computation and memory cost of NAS by taking advantage of the strengths of each in a unified framework, while searching the 1-bit CNNs is more challenging due to the more complicated processes involved. In this paper, we introduce Discrepant Child-Parent Neural Architecture Search (DCP-NAS) to efficiently search 1-bit CNNs, based on a new framework of searching the 1-bit model (Child) under the supervision of a real-valued model (Parent). Particularly, we first utilize a Parent model to calculate a tangent direction, based on which the tangent propagation method is introduced to search the optimized 1-bit Child. We further observe a coupling relationship between the weights and architecture parameters existing in such differentiable frameworks. To address the issue, we propose a decoupled optimization method to search an optimized architecture. Extensive experiments demonstrate that our DCP-NAS achieves much better results than prior arts on both CIFAR-10 and ImageNet datasets. In particular, the backbones achieved by our DCP-NAS achieve strong generalization performance on person re-identification and object detection.

Sheng Xu, Peifeng Li, Qiaoming Zhu

Event coreference resolution (ECR) aims to group event mentions referring to the same real-world event into clusters. Most previous studies adopt the "encoding first, then scoring" framework, making the coreference judgment rely on event encoding. Furthermore, current methods struggle to leverage human-summarized ECR rules, e.g., coreferential events should have the same event type, to guide the model. To address these two issues, we propose a prompt-based approach, CorefPrompt, to transform ECR into a cloze-style MLM (masked language model) task. This allows for simultaneous event modeling and coreference discrimination within a single template, with a fully shared context. In addition, we introduce two auxiliary prompt tasks, event-type compatibility and argument compatibility, to explicitly demonstrate the reasoning process of ECR, which helps the model make final predictions. Experimental results show that our method CorefPrompt performs well in a state-of-the-art (SOTA) benchmark.

Sheng Xu, Guiliang Liu, Tarak Kharrat et al.

Success in association football relies on both individual skill and coordinated tactics. While recent advancements in spatio-temporal data and deep learning have enabled predictive analyses like trajectory forecasting, the development of tactical design remains limited. Bridging this gap is essential, as prediction reveals what is likely to occur, whereas tactic generation determines what should occur to achieve strategic objectives. In this work, we present TacticGen, a generative model for adaptable and scalable tactic generation. TacticGen formulates tactics as sequences of multi-agent movements and interactions conditioned on the game context. It employs a multi-agent diffusion transformer with agent-wise self-attention and context-aware cross-attention to capture cooperative and competitive dynamics among players and the ball. Trained with over 3.3 million events and 100 million tracking frames from top-tier leagues, TacticGen achieves state-of-the-art precision in predicting player trajectories. Building on it, TacticGen enables adaptable tactic generation tailored to diverse inference-time objectives through classifier guidance mechanism, specified via rules, natural language, or neural models. Its modeling performance is also inherently scalable. A case study with football experts confirms that TacticGen generates realistic, strategically valuable tactics, demonstrating its practical utility for tactical planning in professional football. The project page is available at: https://shengxu.net/TacticGen/.

Wanghan Xu, Yuhao Zhou, Yifan Zhou et al.

Despite advances in scientific AI, a coherent framework for Scientific General Intelligence (SGI)-the ability to autonomously conceive, investigate, and reason across scientific domains-remains lacking. We present an operational SGI definition grounded in the Practical Inquiry Model (PIM: Deliberation, Conception, Action, Perception) and operationalize it via four scientist-aligned tasks: deep research, idea generation, dry/wet experiments, and experimental reasoning. SGI-Bench comprises over 1,000 expert-curated, cross-disciplinary samples inspired by Science's 125 Big Questions, enabling systematic evaluation of state-of-the-art LLMs. Results reveal gaps: low exact match (10--20%) in deep research despite step-level alignment; ideas lacking feasibility and detail; high code executability but low execution result accuracy in dry experiments; low sequence fidelity in wet protocols; and persistent multimodal comparative-reasoning challenges. We further introduce Test-Time Reinforcement Learning (TTRL), which optimizes retrieval-augmented novelty rewards at inference, enhancing hypothesis novelty without reference answer. Together, our PIM-grounded definition, workflow-centric benchmark, and empirical insights establish a foundation for AI systems that genuinely participate in scientific discovery.

Zhaowei Liu, Xin Guo, Fangqi Lou et al.

Reasoning large language models are rapidly evolving across various domains. However, their capabilities in handling complex financial tasks still require in-depth exploration. In this paper, we introduce Fin-R1, a reasoning large language model specifically designed for the financial sector. Fin-R1 is built using a two-stage architecture, leveraging a financial reasoning dataset distilled and processed based on DeepSeek-R1. Through supervised fine-tuning (SFT) and reinforcement learning (RL) training, it demonstrates performance close to DeepSeek-R1 with a parameter size of 7 billion across a range of financial reasoning tasks. It achieves the state-of-the-art (SOTA) in the FinQA and ConvFinQA tasks between those LLMs in our evaluation, surpassing larger models in other tasks as well. Fin-R1 showcases strong reasoning and decision-making capabilities, providing solutions to various problems encountered in the financial domain. Our code is available at https://github.com/SUFE-AIFLM-Lab/Fin-R1.

Zhi Jin, Sheng Xu, Xiang Zhang et al.

De novo peptide sequencing from mass spectrometry (MS) data is a critical task in proteomics research. Traditional de novo algorithms have encountered a bottleneck in accuracy due to the inherent complexity of proteomics data. While deep learning-based methods have shown progress, they reduce the problem to a translation task, potentially overlooking critical nuances between spectra and peptides. In our research, we present ContraNovo, a pioneering algorithm that leverages contrastive learning to extract the relationship between spectra and peptides and incorporates the mass information into peptide decoding, aiming to address these intricacies more efficiently. Through rigorous evaluations on two benchmark datasets, ContraNovo consistently outshines contemporary state-of-the-art solutions, underscoring its promising potential in enhancing de novo peptide sequencing. The source code is available at https://github.com/BEAM-Labs/ContraNovo.

Yifei Liu, Zhihang Zhong, Yifan Zhan et al.

While 3D Gaussian Splatting (3DGS) has demonstrated remarkable performance in novel view synthesis and real-time rendering, the high memory consumption due to the use of millions of Gaussians limits its practicality. To mitigate this issue, improvements have been made by pruning unnecessary Gaussians, either through a hand-crafted criterion or by using learned masks. However, these methods deterministically remove Gaussians based on a snapshot of the pruning moment, leading to sub-optimized reconstruction performance from a long-term perspective. To address this issue, we introduce MaskGaussian, which models Gaussians as probabilistic entities rather than permanently removing them, and utilize them according to their probability of existence. To achieve this, we propose a masked-rasterization technique that enables unused yet probabilistically existing Gaussians to receive gradients, allowing for dynamic assessment of their contribution to the evolving scene and adjustment of their probability of existence. Hence, the importance of Gaussians iteratively changes and the pruned Gaussians are selected diversely. Extensive experiments demonstrate the superiority of the proposed method in achieving better rendering quality with fewer Gaussians than previous pruning methods, pruning over 60% of Gaussians on average with only a 0.02 PSNR decline. Our code can be found at: https://github.com/kaikai23/MaskGaussian

Zhiming Wang, Mingze Wang, Sheng Xu et al.

Remote Sensing Image Change Captioning (RSICC) aims to generate natural language descriptions of surface changes between multi-temporal remote sensing images, detailing the categories, locations, and dynamics of changed objects (e.g., additions or disappearances). Many current methods attempt to leverage the long-sequence understanding and reasoning capabilities of multimodal large language models (MLLMs) for this task. However, without comprehensive data support, these approaches often alter the essential feature transmission pathways of MLLMs, disrupting the intrinsic knowledge within the models and limiting their potential in RSICC. In this paper, we propose a novel model, CCExpert, based on a new, advanced multimodal large model framework. Firstly, we design a difference-aware integration module to capture multi-scale differences between bi-temporal images and incorporate them into the original image context, thereby enhancing the signal-to-noise ratio of differential features. Secondly, we constructed a high-quality, diversified dataset called CC-Foundation, containing 200,000 image pairs and 1.2 million captions, to provide substantial data support for continue pretraining in this domain. Lastly, we employed a three-stage progressive training process to ensure the deep integration of the difference-aware integration module with the pretrained MLLM. CCExpert achieved a notable performance of $S^*_m=81.80$ on the LEVIR-CC benchmark, significantly surpassing previous state-of-the-art methods. The code and part of the dataset will soon be open-sourced at https://github.com/Meize0729/CCExpert.

Sixu Lin, Junliang Chen, Huaiyuan Xu et al.

Planning and acting in 3D environments is a fundamental capability for robotic manipulation in the real world. Although prior work has explored predictive flow planners to guide 3D manipulation, existing approaches often rely on modular pipelines stacking multiple submodels, resulting in high computational overhead and limited real-time performance. To address these challenges, we introduce RoboFlow4D, a lightweight flow world model that unifies perception and planning by estimating temporal motion in physical 3D space. As an end-to-end framework, RoboFlow4D directly predicts multi-frame 3D flows from visual observations and textual instructions, providing explicit flow-based planning to guide action generation. This design allows seamless integration with general action policies, forming an efficient observation-planning-execution closed loop. Through slow-fast collaboration between flow prediction and action control, RoboFlow4D enables real-time and resource-efficient manipulation. Extensive experiments in both simulation and real-world settings demonstrate that RoboFlow4D consistently improves manipulation success rates and computational efficiency, advancing flow-guided planning for embodied intelligence.

Ruixing Jin, Zicheng Zhu, Ruixiang Ouyang et al.

Learning a generalist control policy for dexterous manipulation typically relies on large-scale datasets. Given the high cost of real-world data collection, a practical alternative is to generate synthetic data through simulation. However, the resulting synthetic data often exhibits a significant gap from real-world distributions. While many prior studies have proposed algorithms to bridge the Sim-to-Real discrepancy, there remains a lack of principled research that grounds these methods in real-world manipulation tasks, particularly their performance on generalist policies such as Vision-Language-Action (VLA) models. In this study, we empirically examine the primary determinants of Sim-to-Real generalization across four dimensions: multi-level domain randomization, photorealistic rendering, physics-realistic modeling, and reinforcement learning updates. To support this study, we design a comprehensive evaluation protocol to quantify the real-world performance of manipulation tasks. The protocol accounts for key variations in background, lighting, distractors, object types, and spatial features. Through experiments involving over 10k real-world trials, we derive critical insights into Sim-to-Real transfer. To inform and advance future studies, we release both the robotic platforms and the evaluation protocol for public access to facilitate independent verification, thereby establishing a realistic and standardized benchmark for dexterous manipulation policies.

Sheng Xu, Enshu Wang, Hongfei Xue et al.

Collaborative perception allows connected vehicles to overcome occlusions and limited viewpoints by sharing sensory information. However, existing approaches struggle to achieve high accuracy under strict bandwidth constraints and remain highly vulnerable to random transmission packet loss. We introduce QPoint2Comm, a quantized point-cloud communication framework that dramatically reduces bandwidth while preserving high-fidelity 3D information. Instead of transmitting intermediate features, QPoint2Comm directly communicates quantized point-cloud indices using a shared codebook, enabling efficient reconstruction with lower bandwidth than feature-based methods. To ensure robustness to possible communication packet loss, we employ a masked training strategy that simulates random packet loss, allowing the model to maintain strong performance even under severe transmission failures. In addition, a cascade attention fusion module is proposed to enhance multi-vehicle information integration. Extensive experiments on both simulated and real-world datasets demonstrate that QPoint2Comm sets a new state of the art in accuracy, communication efficiency, and resilience to packet loss.

Chaonan Ji, Jinwei Qi, Sheng Xu et al.

Existing facial reenactment methods struggle with a trade-off between expressiveness and fine-grained controllability. Holistic facial reenactment models often sacrifice granular control for expressiveness, while methods designed for control may struggle with fidelity and robust disentanglement. Instead of treating facial motion as a monolithic signal, we explore an alternative compositional perspective. In this paper, we introduce PortraitDirector, a novel framework that formulates face reenactment as a hierarchical composition task, achieving high-fidelity and controllable results. We employ a Hierarchical Motion Disentanglement and Composition strategy, deconstructing facial motion into a Spatial Layer for physical movements and a Semantic Layer for emotional content. The Spatial Layer comprises: (i) global head pose, managed via a dedicated representation and injection pathway; (ii) spatially separated local facial expressions, distilled from cropped facial regions and purged of emotional cues via Emotion-Filtering Module leveraging an information bottleneck. The Semantic Layer contains a derived global emotion. The disentangled components are then recomposed into an expressive motion latent. Furthermore, we engineer the framework for real-time performance through a suite of optimizations, including diffusion distillation, causal attention and VAE acceleration. PortraitDirector achieves streaming, high-fidelity, controllable 512 x 512 face reenactment at 20 FPS with a end-to-end 800 ms latency on a single 5090 GPU.

Shuizhou Chen, Lang Yu, Kedu Jin et al.

Virtual cell models aim to enable in silico experimentation by predicting how cells respond to genetic, chemical, or cytokine perturbations from single-cell measurements. In practice, however, large-scale perturbation prediction remains constrained by three coupled bottlenecks: inefficient training and inference pipelines, unstable modeling in high-dimensional sparse expression space, and evaluation protocols that overemphasize reconstruction-like accuracy while underestimating biological fidelity. In this work we present a specialized large-scale foundation model SCALE for virtual cell perturbation prediction that addresses the above limitations jointly. First, we build a BioNeMo-based training and inference framework that substantially improves data throughput, distributed scalability, and deployment efficiency, yielding 12.51* speedup on pretrain and 1.29* on inference over the prior SOTA pipeline under matched system settings. Second, we formulate perturbation prediction as conditional transport and implement it with a set-aware flow architecture that couples LLaMA-based cellular encoding with endpoint-oriented supervision. This design yields more stable training and stronger recovery of perturbation effects. Third, we evaluate the model on Tahoe-100M using a rigorous cell-level protocol centered on biologically meaningful metrics rather than reconstruction alone. On this benchmark, our model improves PDCorr by 12.02% and DE Overlap by 10.66% over STATE. Together, these results suggest that advancing virtual cells requires not only better generative objectives, but also the co-design of scalable infrastructure, stable transport modeling, and biologically faithful evaluation.

Joe Kileel, Oscar Mickelin, Amit Singer et al.

Cryo-electron microscopy (cryo-EM) is a powerful imaging technique for reconstructing three-dimensional molecular structures from noisy tomographic projection images of randomly oriented particles. We introduce a new data fusion framework, termed the method of double moments (MoDM), which reconstructs molecular structures from two instances of the second-order moment of projection images obtained under distinct orientation distributions--one uniform, the other non-uniform and unknown. We prove that these moments generically uniquely determine the underlying structure, up to a global rotation and reflection, and we develop a convex-relaxation-based algorithm that achieves accurate recovery using only second-order statistics. Our results demonstrate the advantage of collecting and modeling multiple datasets under different experimental conditions, illustrating that leveraging dataset diversity can substantially enhance reconstruction quality in computational imaging tasks.

Sheng Xu, Ruixing Jin, Huayi Zhou et al.

Although robotic manipulation has made significant progress, reliable execution remains challenging because task failures are inevitable in dynamic and unstructured environments. To handle such failures, existing frameworks typically follow a stepwise detect-reason-recover pipeline, which often incurs high latency and limited robustness due to delayed reasoning and reactive planning. Inspired by the human capability to anticipate and proactively plan for potential failures, we introduce AgentChord, an agentic system that models a manipulation task as a directed task graph. Before execution, this graph is enriched with anticipatory recovery branches that specify context-aware corrective behaviors, enabling immediate and targeted responses when failures occur. Specifically, AgentChord operates through a choreography of specialized agents: a composer that structures the nominal task graph, an arranger that augments the graph with anticipatory recovery branches, and a conductor that compiles and coordinates executable transitions using low-latency monitors to detect deviations and trigger pre-compiled recoveries without re-planning. Empirical studies on diverse long-horizon bimanual manipulation tasks demonstrate that AgentChord substantially improves success rates and execution efficiency, advancing the reliability and autonomy of real-world robotic systems. The project page is available at: https://shengxu.net/AgentChord/.

Xiang Zhang, Jiaqi Wei, Zijie Qiu et al.

Autoregressive (AR) models, common in sequence generation, are limited in many biological tasks such as de novo peptide sequencing and protein modeling by their unidirectional nature, failing to capture crucial global bidirectional token dependencies. Non-Autoregressive (NAR) models offer holistic, bidirectional representations but face challenges with generative coherence and scalability. To transcend this, we propose a hybrid framework enhancing AR generation by dynamically integrating rich contextual information from non-autoregressive mechanisms. Our approach couples a shared input encoder with two decoders: a non-autoregressive one learning latent bidirectional biological features, and an AR decoder synthesizing the biological sequence by leveraging these bidirectional features. A novel cross-decoder attention module enables the AR decoder to iteratively query and integrate these bidirectional features, enriching its predictions. This synergy is cultivated via a tailored training strategy with importance annealing for balanced objectives and cross-decoder gradient blocking for stable, focused learning. Evaluations on a demanding nine-species benchmark of de novo peptide sequencing show that our model substantially surpasses AR and NAR baselines. It uniquely harmonizes AR stability with NAR contextual awareness, delivering robust, superior performance on diverse downstream data. This research advances biological sequence modeling techniques and contributes a novel architectural paradigm for augmenting AR models with enhanced bidirectional understanding for complex sequence generation. Code is available at https://github.com/BEAM-Labs/denovo.

Liu Zhang, Oscar Mickelin, Sheng Xu et al.

Since Pearson [Philosophical Transactions of the Royal Society of London. A, 185 (1894), pp. 71-110] first applied the method of moments (MM) for modeling data as a mixture of one-dimensional Gaussians, moment-based estimation methods have proliferated. Among these methods, the generalized method of moments (GMM) improves the statistical efficiency of MM by weighting the moments appropriately. However, the computational complexity and storage complexity of MM and GMM grow exponentially with the dimension, making these methods impractical for high-dimensional data or when higher-order moments are required. Such computational bottlenecks are more severe in GMM since it additionally requires estimating a large weighting matrix. To overcome these bottlenecks, we propose the diagonally-weighted GMM (DGMM), which achieves a balance among statistical efficiency, computational complexity, and numerical stability. We apply DGMM to study the parameter estimation problem for weakly separated heteroscedastic low-rank Gaussian mixtures and design a computationally efficient and numerically stable algorithm that obtains the DGMM estimator without explicitly computing or storing the moment tensors. We implement the proposed algorithm and empirically validate the advantages of DGMM: in numerical studies, DGMM attains smaller estimation errors while requiring substantially shorter runtime than MM and GMM. The code and data will be available upon publication at https://github.com/liu-lzhang/dgmm.

Qingcheng Zhu, Yangyang Ren, Linlin Yang et al.

Deploying large language models (LLMs) is challenging due to their massive parameters and high computational costs. Ultra low-bit quantization can significantly reduce storage and accelerate inference, but extreme compression (i.e., mean bit-width <= 2) often leads to severe performance degradation. To address this, we propose Squeeze10-LLM, effectively "squeezing" 16-bit LLMs' weights by 10 times. Specifically, Squeeze10-LLM is a staged mixed-precision post-training quantization (PTQ) framework and achieves an average of 1.6 bits per weight by quantizing 80% of the weights to 1 bit and 20% to 4 bits. We introduce Squeeze10LLM with two key innovations: Post-Binarization Activation Robustness (PBAR) and Full Information Activation Supervision (FIAS). PBAR is a refined weight significance metric that accounts for the impact of quantization on activations, improving accuracy in low-bit settings. FIAS is a strategy that preserves full activation information during quantization to mitigate cumulative error propagation across layers. Experiments on LLaMA and LLaMA2 show that Squeeze10-LLM achieves state-of-the-art performance for sub-2bit weight-only quantization, improving average accuracy from 43% to 56% on six zero-shot classification tasks--a significant boost over existing PTQ methods. Our code will be released upon publication.

Yuchen Ren, Zhiyuan Chen, Lifeng Qiao et al.

RNA plays a pivotal role in translating genetic instructions into functional outcomes, underscoring its importance in biological processes and disease mechanisms. Despite the emergence of numerous deep learning approaches for RNA, particularly universal RNA language models, there remains a significant lack of standardized benchmarks to assess the effectiveness of these methods. In this study, we introduce the first comprehensive RNA benchmark BEACON (\textbf{BE}nchm\textbf{A}rk for \textbf{CO}mprehensive R\textbf{N}A Task and Language Models). First, BEACON comprises 13 distinct tasks derived from extensive previous work covering structural analysis, functional studies, and engineering applications, enabling a comprehensive assessment of the performance of methods on various RNA understanding tasks. Second, we examine a range of models, including traditional approaches like CNNs, as well as advanced RNA foundation models based on language models, offering valuable insights into the task-specific performances of these models. Third, we investigate the vital RNA language model components from the tokenizer and positional encoding aspects. Notably, our findings emphasize the superiority of single nucleotide tokenization and the effectiveness of Attention with Linear Biases (ALiBi) over traditional positional encoding methods. Based on these insights, a simple yet strong baseline called BEACON-B is proposed, which can achieve outstanding performance with limited data and computational resources. The datasets and source code of our benchmark are available at https://github.com/terry-r123/RNABenchmark.

Byungsoo Jeon, Sunghyun Park, Peiyuan Liao et al.

The strong demand for efficient and performant deployment of Deep Learning (DL) applications prompts the rapid development of a rich DL ecosystem. To keep up with this fast advancement, it is crucial for modern DL frameworks to efficiently integrate a variety of optimized tensor algebra libraries and runtimes as their backends and generate the fastest possible executable using these backends. However, current DL frameworks require significant manual effort and expertise to integrate every new backend while failing to unleash its full potential. Given the fast-evolving nature of the DL ecosystem, this manual approach often slows down continuous innovations across different layers; it prevents hardware vendors from the fast deployment of their cutting-edge libraries, DL framework developers must repeatedly adjust their hand-coded rules to accommodate new versions of libraries, and machine learning practitioners need to wait for the integration of new technologies and often encounter unsatisfactory performance. In this paper, we propose Collage, a DL framework that offers seamless integration of DL backends. Collage provides an expressive backend registration interface that allows users to precisely specify the capability of various backends. By leveraging the specifications of available backends, Collage automatically searches for an optimized backend placement strategy for a given workload and execution environment. Our evaluation shows that Collage outperforms the best existing framework for each hardware by $1.26\times$, $1.43\times$, $1.40\times$ on average on NVIDIA's RTX 2070 GPU, V100 GPU, and Intel's Xeon 8259CL CPU, respectively. Collage has been open-sourced and deployed in Apache TVM.

Xinrui Song, Hengtao Guo, Xuanang Xu et al.

Prostate cancer biopsy benefits from accurate fusion of transrectal ultrasound (TRUS) and magnetic resonance (MR) images. In the past few years, convolutional neural networks (CNNs) have been proved powerful in extracting image features crucial for image registration. However, challenging applications and recent advances in computer vision suggest that CNNs are quite limited in its ability to understand spatial correspondence between features, a task in which the self-attention mechanism excels. This paper aims to develop a self-attention mechanism specifically for cross-modal image registration. Our proposed cross-modal attention block effectively maps each of the features in one volume to all features in the corresponding volume. Our experimental results demonstrate that a CNN network designed with the cross-modal attention block embedded outperforms an advanced CNN network 10 times of its size. We also incorporated visualization techniques to improve the interpretability of our network. The source code of our work is available at https://github.com/DIAL-RPI/Attention-Reg .

Xuehui Yu, Zhenjun Han, Yuqi Gong et al.

The 1st Tiny Object Detection (TOD) Challenge aims to encourage research in developing novel and accurate methods for tiny object detection in images which have wide views, with a current focus on tiny person detection. The TinyPerson dataset was used for the TOD Challenge and is publicly released. It has 1610 images and 72651 box-levelannotations. Around 36 participating teams from the globe competed inthe 1st TOD Challenge. In this paper, we provide a brief summary of the1st TOD Challenge including brief introductions to the top three methods.The submission leaderboard will be reopened for researchers that areinterested in the TOD challenge. The benchmark dataset and other information can be found at: https://github.com/ucas-vg/TinyBenchmark.

Hengtao Guo, Sheng Xu, Bradford Wood et al.

Transrectal ultrasound (US) is the most commonly used imaging modality to guide prostate biopsy and its 3D volume provides even richer context information. Current methods for 3D volume reconstruction from freehand US scans require external tracking devices to provide spatial position for every frame. In this paper, we propose a deep contextual learning network (DCL-Net), which can efficiently exploit the image feature relationship between US frames and reconstruct 3D US volumes without any tracking device. The proposed DCL-Net utilizes 3D convolutions over a US video segment for feature extraction. An embedded self-attention module makes the network focus on the speckle-rich areas for better spatial movement prediction. We also propose a novel case-wise correlation loss to stabilize the training process for improved accuracy. Highly promising results have been obtained by using the developed method. The experiments with ablation studies demonstrate superior performance of the proposed method by comparing against other state-of-the-art methods. Source code of this work is publicly available at https://github.com/DIAL-RPI/FreehandUSRecon.

Xiangen Hu, Jiarui Tong, Sheng Xu

Training and education in human-centered fields require authentic practice, yet realistic simulations of human behavior have remained limited. We present a multi-agent psychological simulation system that models internal cognitive-affective processes to generate believable human behaviors. In contrast to black-box neural models, this system is grounded in established psychological theories (e.g., self-efficacy, mindset, social constructivism) and explicitly simulates an ``inner parliament'' of agents corresponding to key psychological factors. These agents deliberate and interact to determine the system's output behavior, enabling unprecedented transparency and alignment with human psychology. We describe the system's architecture and theoretical foundations, illustrate its use in teacher training and research, and discuss how it embodies principles of social learning, cognitive apprenticeship, deliberate practice, and meta-cognition.

Taige Luo, Junru Xie, Chenyang Fan et al.

Intelligent forest tree breeding has advanced plant phenotyping, yet existing research largely focuses on large-leaf agricultural crops, with limited attention to fine-grained leaf analysis of sapling trees in open-field environments. Natural scenes introduce challenges including scale variation, illumination changes, and irregular leaf morphology. To address these issues, we collected UAV RGB imagery of field-grown saplings and constructed the Poplar-leaf dataset, containing 1,202 branches and 19,876 pixel-level annotated leaf instances. To our knowledge, this is the first instance segmentation dataset specifically designed for forestry leaves in open-field conditions. We propose LeafInst, a novel segmentation framework tailored for irregular and multi-scale leaf structures. The model integrates an Asymptotic Feature Pyramid Network (AFPN) for multi-scale perception, a Dynamic Asymmetric Spatial Perception (DASP) module for irregular shape modeling, and a dual-residual Dynamic Anomalous Regression Head (DARH) with Top-down Concatenation decoder Feature Fusion (TCFU) to improve detection and segmentation performance. On Poplar-leaf, LeafInst achieves 68.4 mAP, outperforming YOLOv11 by 7.1 percent and MaskDINO by 6.5 percent. On the public PhenoBench benchmark, it reaches 52.7 box mAP, exceeding MaskDINO by 3.4 percent. Additional experiments demonstrate strong generalization and practical utility for large-scale leaf phenotyping.

Mingze Wang, Lili Su, Cilin Yan et al.

The intelligent interpretation of buildings plays a significant role in urban planning and management, macroeconomic analysis, population dynamics, etc. Remote sensing image building interpretation primarily encompasses building extraction and change detection. However, current methodologies often treat these two tasks as separate entities, thereby failing to leverage shared knowledge. Moreover, the complexity and diversity of remote sensing image scenes pose additional challenges, as most algorithms are designed to model individual small datasets, thus lacking cross-scene generalization. In this paper, we propose a comprehensive remote sensing image building understanding model, termed RSBuilding, developed from the perspective of the foundation model. RSBuilding is designed to enhance cross-scene generalization and task universality. Specifically, we extract image features based on the prior knowledge of the foundation model and devise a multi-level feature sampler to augment scale information. To unify task representation and integrate image spatiotemporal clues, we introduce a cross-attention decoder with task prompts. Addressing the current shortage of datasets that incorporate annotations for both tasks, we have developed a federated training strategy to facilitate smooth model convergence even when supervision for some tasks is missing, thereby bolstering the complementarity of different tasks. Our model was trained on a dataset comprising up to 245,000 images and validated on multiple building extraction and change detection datasets. The experimental results substantiate that RSBuilding can concurrently handle two structurally distinct tasks and exhibits robust zero-shot generalization capabilities.

Rui Sun, Yifan Sun, Sheng Xu et al.

Reinforcement Learning (RL) has enabled Large Language Models (LLMs) to achieve remarkable reasoning in domains like mathematics and coding, where verifiable rewards provide clear signals. However, extending this paradigm to financial decision is challenged by the market's stochastic nature: rewards are verifiable but inherently noisy, causing standard RL to degenerate into reward hacking. To address this, we propose Trade-R1, a model training framework that bridges verifiable rewards to stochastic environments via process-level reasoning verification. Our key innovation is a verification method that transforms the problem of evaluating reasoning over lengthy financial documents into a structured Retrieval-Augmented Generation (RAG) task. We construct a triangular consistency metric, assessing pairwise alignment between retrieved evidence, reasoning chains, and decisions to serve as a validity filter for noisy market returns. We explore two reward integration strategies: Fixed-effect Semantic Reward (FSR) for stable alignment signals, and Dynamic-effect Semantic Reward (DSR) for coupled magnitude optimization. Experiments on different country asset selection demonstrate that our paradigm reduces reward hacking, with DSR achieving superior cross-market generalization while maintaining the highest reasoning consistency.

Tingchen Ma, Yongsheng Ou, Sheng Xu

The bundle adjustment (BA) algorithm is a widely used nonlinear optimization technique in the backend of Simultaneous Localization and Mapping (SLAM) systems. By leveraging the co-view relationships of landmarks from multiple perspectives, the BA method constructs a joint estimation model for both poses and landmarks, enabling the system to generate refined maps and reduce front-end localization errors. However, there are unique challenges when applying the BA for LiDAR data, due to the large volume of 3D points. Exploring a robust LiDAR BA estimator and achieving accurate solutions is a very important issue. In this work, firstly we propose a novel mean square group metric (MSGM) to build the optimization objective in the LiDAR BA algorithm. This metric applies mean square transformation to uniformly process the measurement of plane landmarks from one sampling period. The transformed metric ensures scale interpretability, and does not requie a time-consuming point-by-point calculation. Secondly, by integrating a robust kernel function, the metrics involved in the BA algorithm are reweighted, and thus enhancing the robustness of the solution process. Thirdly, based on the proposed robust LiDAR BA model, we derived an explicit second-order estimator (RSO-BA). This estimator employs analytical formulas for Hessian and gradient calculations, ensuring the precision of the BA solution. Finally, we verify the merits of the proposed RSO-BA estimator against existing implicit second-order and explicit approximate second-order estimators using the publicly available datasets. The experimental results demonstrate that the RSO-BA estimator outperforms its counterparts regarding registration accuracy and robustness, particularly in large-scale or complex unstructured environments.

Teng Chen, Sheng Xu, Feixiang Guo et al.

Unlike traditional fact-based retrieval, rationale-based retrieval typically necessitates cross-encoding of query-document pairs using large language models, incurring substantial computational costs. To address this limitation, we propose Rabtriever, which independently encodes queries and documents, while providing comparable cross query-document comprehension capabilities to rerankers. We start from training a LLM-based generative reranker, which puts the document prior to the query and prompts the LLM to generate the relevance score by log probabilities. We then employ it as the teacher of an on-policy distillation framework, with Rabtriever as the student to reconstruct the teacher's contextual-aware query embedding. To achieve this effect, Rabtriever is first initialized from the teacher, with parameters frozen. The Joint-Embedding Predictive Architecture (JEPA) paradigm is then adopted, which integrates a lightweight, trainable predictor between LLM layers and heads, projecting the query embedding into a new hidden space, with the document embedding as the latent vector. JEPA then minimizes the distribution difference between this projected embedding and the teacher embedding. To strengthen the sampling efficiency of on-policy distillation, we also add an auxiliary loss on the reverse KL of LLM logits, to reshape the student's logit distribution. Rabtriever optimizes the teacher's quadratic complexity on the document length to linear, verified both theoretically and empirically. Experiments show that Rabtriever outperforms different retriever baselines across diverse rationale-based tasks, including empathetic conversations and robotic manipulations, with minor accuracy degradation from the reranker. Rabtriever also generalizes well on traditional retrieval benchmarks such as MS MARCO and BEIR, with comparable performance to the best retriever baseline.

Jinwei Qi, Chaonan Ji, Sheng Xu et al.

Real-time interactive video-chat portraits have been increasingly recognized as the future trend, particularly due to the remarkable progress made in text and voice chat technologies. However, existing methods primarily focus on real-time generation of head movements, but struggle to produce synchronized body motions that match these head actions. Additionally, achieving fine-grained control over the speaking style and nuances of facial expressions remains a challenge. To address these limitations, we introduce a novel framework for stylized real-time portrait video generation, enabling expressive and flexible video chat that extends from talking head to upper-body interaction. Our approach consists of the following two stages. The first stage involves efficient hierarchical motion diffusion models, that take both explicit and implicit motion representations into account based on audio inputs, which can generate a diverse range of facial expressions with stylistic control and synchronization between head and body movements. The second stage aims to generate portrait video featuring upper-body movements, including hand gestures. We inject explicit hand control signals into the generator to produce more detailed hand movements, and further perform face refinement to enhance the overall realism and expressiveness of the portrait video. Additionally, our approach supports efficient and continuous generation of upper-body portrait video in maximum 512 * 768 resolution at up to 30fps on 4090 GPU, supporting interactive video-chat in real-time. Experimental results demonstrate the capability of our approach to produce portrait videos with rich expressiveness and natural upper-body movements.

Xin Gao, Li Hu, Siqi Hu et al.

Current state-of-the-art (SOTA) methods for audio-driven character animation demonstrate promising performance for scenarios primarily involving speech and singing. However, they often fall short in more complex film and television productions, which demand sophisticated elements such as nuanced character interactions, realistic body movements, and dynamic camera work. To address this long-standing challenge of achieving film-level character animation, we propose an audio-driven model, which we refere to as Wan-S2V, built upon Wan. Our model achieves significantly enhanced expressiveness and fidelity in cinematic contexts compared to existing approaches. We conducted extensive experiments, benchmarking our method against cutting-edge models such as Hunyuan-Avatar and Omnihuman. The experimental results consistently demonstrate that our approach significantly outperforms these existing solutions. Additionally, we explore the versatility of our method through its applications in long-form video generation and precise video lip-sync editing.

Zijie Qiu, Jiaqi Wei, Xiang Zhang et al.

De novo peptide sequencing is a critical task in proteomics. However, the performance of current deep learning-based methods is limited by the inherent complexity of mass spectrometry data and the heterogeneous distribution of noise signals, leading to data-specific biases. We present RankNovo, the first deep reranking framework that enhances de novo peptide sequencing by leveraging the complementary strengths of multiple sequencing models. RankNovo employs a list-wise reranking approach, modeling candidate peptides as multiple sequence alignments and utilizing axial attention to extract informative features across candidates. Additionally, we introduce two new metrics, PMD (Peptide Mass Deviation) and RMD (residual Mass Deviation), which offer delicate supervision by quantifying mass differences between peptides at both the sequence and residue levels. Extensive experiments demonstrate that RankNovo not only surpasses its base models used to generate training candidates for reranking pre-training, but also sets a new state-of-the-art benchmark. Moreover, RankNovo exhibits strong zero-shot generalization to unseen models whose generations were not exposed during training, highlighting its robustness and potential as a universal reranking framework for peptide sequencing. Our work presents a novel reranking strategy that fundamentally challenges existing single-model paradigms and advances the frontier of accurate de novo sequencing. Our source code is provided on GitHub.

Xiangen Hu, Sheng Xu, Richard Tong et al.

This paper explores the synergy between human cognition and Large Language Models (LLMs), highlighting how generative AI can drive personalized learning at scale. We discuss parallels between LLMs and human cognition, emphasizing both the promise and new perspectives on integrating AI systems into education. After examining challenges in aligning technology with pedagogy, we review AutoTutor-one of the earliest Intelligent Tutoring Systems (ITS)-and detail its successes, limitations, and unfulfilled aspirations. We then introduce the Socratic Playground, a next-generation ITS that uses advanced transformer-based models to overcome AutoTutor's constraints and provide personalized, adaptive tutoring. To illustrate its evolving capabilities, we present a JSON-based tutoring prompt that systematically guides learner reflection while tracking misconceptions. Throughout, we underscore the importance of placing pedagogy at the forefront, ensuring that technology's power is harnessed to enhance teaching and learning rather than overshadow it.

Xianliang Li, Jun Luo, Zhiwei Zheng et al.

Momentum-based optimizers are widely adopted for training neural networks. However, the optimal selection of momentum coefficients remains elusive. This uncertainty impedes a clear understanding of the role of momentum in stochastic gradient methods. In this paper, we present a frequency domain analysis framework that interprets the momentum method as a time-variant filter for gradients, where adjustments to momentum coefficients modify the filter characteristics. Our experiments support this perspective and provide a deeper understanding of the mechanism involved. Moreover, our analysis reveals the following significant findings: high-frequency gradient components are undesired in the late stages of training; preserving the original gradient in the early stages, and gradually amplifying low-frequency gradient components during training both enhance performance. Based on these insights, we propose Frequency Stochastic Gradient Descent with Momentum (FSGDM), a heuristic optimizer that dynamically adjusts the momentum filtering characteristic with an empirically effective dynamic magnitude response. Experimental results demonstrate the superiority of FSGDM over conventional momentum optimizers.

Xiang Zhang, Jiaqi Wei, Zijie Qiu et al.

Peptide sequencing-the process of identifying amino acid sequences from mass spectrometry data-is a fundamental task in proteomics. Non-Autoregressive Transformers (NATs) have proven highly effective for this task, outperforming traditional methods. Unlike autoregressive models, which generate tokens sequentially, NATs predict all positions simultaneously, leveraging bidirectional context through unmasked self-attention. However, existing NAT approaches often rely on Connectionist Temporal Classification (CTC) loss, which presents significant optimization challenges due to CTC's complexity and increases the risk of training failures. To address these issues, we propose an improved non-autoregressive peptide sequencing model that incorporates a structured protein sequence curriculum learning strategy. This approach adjusts protein's learning difficulty based on the model's estimated protein generational capabilities through a sampling process, progressively learning peptide generation from simple to complex sequences. Additionally, we introduce a self-refining inference-time module that iteratively enhances predictions using learned NAT token embeddings, improving sequence accuracy at a fine-grained level. Our curriculum learning strategy reduces NAT training failures frequency by more than 90% based on sampled training over various data distributions. Evaluations on nine benchmark species demonstrate that our approach outperforms all previous methods across multiple metrics and species.

Zhongjian Wang, Peng Zhang, Jinwei Qi et al.

Although significant progress has been made in audio-driven talking head generation, text-driven methods remain underexplored. In this work, we present OmniTalker, a unified framework that jointly generates synchronized talking audio-video content from input text while emulating the speaking and facial movement styles of the target identity, including speech characteristics, head motion, and facial dynamics. Our framework adopts a dual-branch diffusion transformer (DiT) architecture, with one branch dedicated to audio generation and the other to video synthesis. At the shallow layers, cross-modal fusion modules are introduced to integrate information between the two modalities. In deeper layers, each modality is processed independently, with the generated audio decoded by a vocoder and the video rendered using a GAN-based high-quality visual renderer. Leveraging the in-context learning capability of DiT through a masked-infilling strategy, our model can simultaneously capture both audio and visual styles without requiring explicit style extraction modules. Thanks to the efficiency of the DiT backbone and the optimized visual renderer, OmniTalker achieves real-time inference at 25 FPS. To the best of our knowledge, OmniTalker is the first one-shot framework capable of jointly modeling speech and facial styles in real time. Extensive experiments demonstrate its superiority over existing methods in terms of generation quality, particularly in preserving style consistency and ensuring precise audio-video synchronization, all while maintaining efficient inference.

Yuhan Chen, Shang Qu, Zhiqiang Gao et al.

Post-translational modifications (PTMs) serve as a dynamic chemical language regulating protein function, yet current proteomic methods remain blind to a vast portion of the modified proteome. Standard database search algorithms suffer from a combinatorial explosion of search spaces, limiting the identification of uncharacterized or complex modifications. Here we introduce OmniNovo, a unified deep learning framework for reference-free sequencing of unmodified and modified peptides directly from tandem mass spectra. Unlike existing tools restricted to specific modification types, OmniNovo learns universal fragmentation rules to decipher diverse PTMs within a single coherent model. By integrating a mass-constrained decoding algorithm with rigorous false discovery rate estimation, OmniNovo achieves state-of-the-art accuracy, identifying 51\% more peptides than standard approaches at a 1\% false discovery rate. Crucially, the model generalizes to biological sites unseen during training, illuminating the dark matter of the proteome and enabling unbiased comprehensive analysis of cellular regulation.

Yichen Yang, Hong Li, Haodong Zhu et al.

Existing autoregressive (AR) methods for generating artist-designed meshes struggle to balance global structural consistency with high-fidelity local details, and are susceptible to error accumulation. To address this, we propose PartDiffuser, a novel semi-autoregressive diffusion framework for point-cloud-to-mesh generation. The method first performs semantic segmentation on the mesh and then operates in a "part-wise" manner: it employs autoregression between parts to ensure global topology, while utilizing a parallel discrete diffusion process within each semantic part to precisely reconstruct high-frequency geometric features. PartDiffuser is based on the DiT architecture and introduces a part-aware cross-attention mechanism, using point clouds as hierarchical geometric conditioning to dynamically control the generation process, thereby effectively decoupling the global and local generation tasks. Experiments demonstrate that this method significantly outperforms state-of-the-art (SOTA) models in generating 3D meshes with rich detail, exhibiting exceptional detail representation suitable for real-world applications.