Maria Soledad Aronna

Maria Soledad Aronna, J. Frederic Bonnans, Andrei V. Dmitruk et al.

This paper deals with optimal control problems for systems affine in the control variable. We consider nonnegativity constraints on the control, and finitely many equality and inequality constraints on the final state. First, we obtain second order necessary optimality conditions. Secondly, we derive a second order sufficient condition for the scalar control case.

Paulo Amorim, Maria Soledad Aronna, Debora de Oliveira Medeiros

We present an epidemiological model for vector-borne diseases that includes within-host viral load and antibody dynamics using structured transport equations. By incorporating the internal dynamics into the infected and recovered host compartments, the formulation introduces nonlinearities and nonlocalities. We establish analytical properties, including well-posedness and mass conservation, and characterize its characteristic curves. Furthermore, we derive a simplified Uniform Host Response (UHR) model featuring delay-type terms. For both the full and UHR frameworks, the basic reproduction number is determined and shown to serve as a threshold for the existence of an endemic equilibrium, and is related to the linear stability of the disease-free state. Finally, numerical experiments, parameterized specifically for Dengue fever, demonstrate how within-host mechanisms influence population-level epidemiological outcomes.