Kritika Singh

Cristina Almagro-Pérez, Andrew H. Song, Luca Weishaupt et al.

A comprehensive three-dimensional (3D) map of tissue architecture and gene expression is crucial for illuminating the complexity and heterogeneity of tissues across diverse biomedical applications. However, most spatial transcriptomics (ST) approaches remain limited to two-dimensional (2D) sections of tissue. Although current 3D ST methods hold promise, they typically require extensive tissue sectioning, are complex, are not compatible with non-destructive 3D tissue imaging technologies, and often lack scalability. Here, we present VOlumetrically Resolved Transcriptomics EXpression (VORTEX), an AI framework that leverages 3D tissue morphology and minimal 2D ST to predict volumetric 3D ST. By pretraining on diverse 3D morphology-transcriptomic pairs from heterogeneous tissue samples and then fine-tuning on minimal 2D ST data from a specific volume of interest, VORTEX learns both generic tissue-related and sample-specific morphological correlates of gene expression. This approach enables dense, high-throughput, and fast 3D ST, scaling seamlessly to large tissue volumes far beyond the reach of existing 3D ST techniques. By offering a cost-effective and minimally destructive route to obtaining volumetric molecular insights, we anticipate that VORTEX will accelerate biomarker discovery and our understanding of morphomolecular associations and cell states in complex tissues. Interactive 3D ST volumes can be viewed at https://vortex-demo.github.io/

Leda Sarı, Kritika Singh, Jiatong Zhou et al.

Although speaker verification has conventionally been an audio-only task, some practical applications provide both audio and visual streams of input. In these cases, the visual stream provides complementary information and can often be leveraged in conjunction with the acoustics of speech to improve verification performance. In this study, we explore audio-visual approaches to speaker verification, starting with standard fusion techniques to learn joint audio-visual (AV) embeddings, and then propose a novel approach to handle cross-modal verification at test time. Specifically, we investigate unimodal and concatenation based AV fusion and report the lowest AV equal error rate (EER) of 0.7% on the VoxCeleb1 dataset using our best system. As these methods lack the ability to do cross-modal verification, we introduce a multi-view model which uses a shared classifier to map audio and video into the same space. This new approach achieves 28% EER on VoxCeleb1 in the challenging testing condition of cross-modal verification.

Kritika Singh, Dmytro Okhonko, Jun Liu et al.

Supervised ASR models have reached unprecedented levels of accuracy, thanks in part to ever-increasing amounts of labelled training data. However, in many applications and locales, only moderate amounts of data are available, which has led to a surge in semi- and weakly-supervised learning research. In this paper, we conduct a large-scale study evaluating the effectiveness of weakly-supervised learning for speech recognition by using loosely related contextual information as a surrogate for ground-truth labels. For weakly supervised training, we use 50k hours of public English social media videos along with their respective titles and post text to train an encoder-decoder transformer model. Our best encoder-decoder models achieve an average of 20.8% WER reduction over a 1000 hours supervised baseline, and an average of 13.4% WER reduction when using only the weakly supervised encoder for CTC fine-tuning. Our results show that our setup for weak supervision improved both the encoder acoustic representations as well as the decoder language generation abilities.

Chunxi Liu, Qiaochu Zhang, Xiaohui Zhang et al.

Towards developing high-performing ASR for low-resource languages, approaches to address the lack of resources are to make use of data from multiple languages, and to augment the training data by creating acoustic variations. In this work we present a single grapheme-based ASR model learned on 7 geographically proximal languages, using standard hybrid BLSTM-HMM acoustic models with lattice-free MMI objective. We build the single ASR grapheme set via taking the union over each language-specific grapheme set, and we find such multilingual graphemic hybrid ASR model can perform language-independent recognition on all 7 languages, and substantially outperform each monolingual ASR model. Secondly, we evaluate the efficacy of multiple data augmentation alternatives within language, as well as their complementarity with multilingual modeling. Overall, we show that the proposed multilingual graphemic hybrid ASR with various data augmentation can not only recognize any within training set languages, but also provide large ASR performance improvements.