Jiook Cha

Sangyoon Bae, Miruna Oprescu, David Keetae Park et al.

Inferring directed connectivity from neuroimaging is an ill-posed inverse problem: recorded signals are distorted by hemodynamic filtering and volume conduction, which can mask true neural interactions. Many existing methods conflate these observation artifacts with genuine neural influence, risking spurious causal graphs driven by the measurement process. We introduce INCAMA (INdirect CAusal MAmba), a latent-space causal discovery framework that explicitly accounts for measurement physics to separate neural dynamics from indirect observations. INCAMA integrates a physics-aware inversion module with a nonstationarity-driven, delay-sensitive causal discovery model based on selective state-space sequences. Leveraging nonstationary mechanism shifts as soft interventions, we establish identifiability of delayed causal structure from indirect measurements and a stability bound that quantifies how inversion error affects graph recovery. We validate INCAMA on large-scale biophysical simulations across EEG and fMRI, where it significantly outperforms standard pipelines. We further demonstrate zero-shot generalization to real-world fMRI from the Human Connectome Project: without domain-specific fine-tuning, INCAMA recovers canonical visuo-motor pathways (e.g., $V1 \to V2$ and $M1 \leftrightarrow S1$) consistent with established neuroanatomy, supporting its use for whole-brain causal inference.

Junghoon Justin Park, Yeonghyeon Park, Jiook Cha

Integrating quantum circuits into deep learning pipelines remains challenging due to heuristic design limitations. We propose Q-DIVER, a hybrid framework combining a large-scale pretrained EEG encoder (DIVER-1) with a differentiable quantum classifier. Unlike fixed-ansatz approaches, we employ Differentiable Quantum Architecture Search to autonomously discover task-optimal circuit topologies during end-to-end fine-tuning. On the PhysioNet Motor Imagery dataset, our quantum classifier achieves predictive performance comparable to classical multi-layer perceptrons (Test F1: 63.49\%) while using approximately \textbf{50$\times$ fewer task-specific head parameters} (2.10M vs. 105.02M). These results validate quantum transfer learning as a parameter-efficient strategy for high-dimensional biological signal processing.

William Watkins, Heehwan Wang, Sangyoon Bae et al.

The utility of machine learning has rapidly expanded in the last two decades and presents an ethical challenge. Papernot et. al. developed a technique, known as Private Aggregation of Teacher Ensembles (PATE) to enable federated learning in which multiple teacher models are trained on disjoint datasets. This study is the first to apply PATE to an ensemble of quantum neural networks (QNN) to pave a new way of ensuring privacy in quantum machine learning (QML) models.

Junghoon Justin Park, Jiook Cha, Samuel Yen-Chi Chen et al.

Practical Quantum Machine Learning (QML) is challenged by noise, limited scalability, and poor trainability in Variational Quantum Circuits (VQCs) on current hardware. We propose a multi-chip ensemble VQC framework that systematically overcomes these hurdles. By partitioning high-dimensional computations across ensembles of smaller, independently operating quantum chips and leveraging controlled inter-chip entanglement boundaries, our approach demonstrably mitigates barren plateaus, enhances generalization, and uniquely reduces both quantum error bias and variance simultaneously without additional mitigation overhead. This allows for robust processing of large-scale data, as validated on standard benchmarks (MNIST, FashionMNIST, CIFAR-10) and a real-world PhysioNet EEG dataset, aligning with emerging modular quantum hardware and paving the way for more scalable QML.

Junghoon Justin Park, Huan-Hsin Tseng, Shinjae Yoo et al.

Quantum reinforcement learning (QRL) promises compact function approximators with access to vast Hilbert spaces, but its practical progress is slowed by NISQ-era constraints such as limited qubits and noise accumulation. We introduce a multi-chip ensemble framework using multiple small Quantum Convolutional Neural Networks (QCNNs) to overcome these constraints. Our approach partitions complex, high-dimensional observations from the Super Mario Bros environment across independent quantum circuits, then classically aggregates their outputs within a Double Deep Q-Network (DDQN) framework. This modular architecture enables QRL in complex environments previously inaccessible to quantum agents, achieving superior performance and learning stability compared to classical baselines and single-chip quantum models. The multi-chip ensemble demonstrates enhanced scalability by reducing information loss from dimensionality reduction while remaining implementable on near-term quantum hardware, providing a practical pathway for applying QRL to real-world problems.

Junghoon Justin Park, Maria Pak, Sebin Lee et al.

Quantum machine learning models for sequential data face scalability challenges with complex multivariate signals. We introduce the Hybrid Quantum Temporal Convolutional Network (HQTCN), which combines classical temporal windowing with a quantum convolutional neural network core. By applying a shared quantum circuit across temporal windows, HQTCN captures long-range dependencies while achieving significant parameter reduction. Evaluated on synthetic NARMA sequences and high-dimensional EEG time-series, HQTCN performs competitively with classical baselines on univariate data and outperforms all baselines on multivariate tasks. The model demonstrates particular strength under data-limited conditions, maintaining high performance with substantially fewer parameters than conventional approaches. These results establish HQTCN as a parameter-efficient approach for multivariate time-series analysis.

Sangyoon Bae, Jiook Cha

We introduce CausalMamba, a scalable framework that addresses fundamental limitations in fMRI-based causal inference: the ill-posed nature of inferring neural causality from hemodynamically distorted BOLD signals and the computational intractability of existing methods like Dynamic Causal Modeling (DCM). Our approach decomposes this complex inverse problem into two tractable stages: BOLD deconvolution to recover latent neural activity, followed by causal graph inference using a novel Conditional Mamba architecture. On simulated data, CausalMamba achieves 37% higher accuracy than DCM. Critically, when applied to real task fMRI data, our method recovers well-established neural pathways with 88% fidelity, whereas conventional approaches fail to identify these canonical circuits in over 99% of subjects. Furthermore, our network analysis of working memory data reveals that the brain strategically shifts its primary causal hub-recruiting executive or salience networks depending on the stimulus-a sophisticated reconfiguration that remains undetected by traditional methods. This work provides neuroscientists with a practical tool for large-scale causal inference that captures both fundamental circuit motifs and flexible network dynamics underlying cognitive function.