Jin Yuan

Guojin Zhong, Jin Yuan, Pan Wang et al.

The recently rising markup-to-image generation poses greater challenges as compared to natural image generation, due to its low tolerance for errors as well as the complex sequence and context correlations between markup and rendered image. This paper proposes a novel model named "Contrast-augmented Diffusion Model with Fine-grained Sequence Alignment" (FSA-CDM), which introduces contrastive positive/negative samples into the diffusion model to boost performance for markup-to-image generation. Technically, we design a fine-grained cross-modal alignment module to well explore the sequence similarity between the two modalities for learning robust feature representations. To improve the generalization ability, we propose a contrast-augmented diffusion model to explicitly explore positive and negative samples by maximizing a novel contrastive variational objective, which is mathematically inferred to provide a tighter bound for the model's optimization. Moreover, the context-aware cross attention module is developed to capture the contextual information within markup language during the denoising process, yielding better noise prediction results. Extensive experiments are conducted on four benchmark datasets from different domains, and the experimental results demonstrate the effectiveness of the proposed components in FSA-CDM, significantly exceeding state-of-the-art performance by about 2%-12% DTW improvements. The code will be released at https://github.com/zgj77/FSACDM.

Peng Xiao, Zhongzhou Luo, Yuqing Deng et al.

Meibography is a non-contact imaging technique used by ophthalmologists to assist in the evaluation and diagnosis of meibomian gland dysfunction (MGD). While artificial qualitative analysis of meibography images could lead to low repeatability and efficiency and multi-parametric analysis is demanding to offer more comprehensive information in discovering subtle changes of meibomian glands during MGD progression, we developed an automated and multi-parametric algorithm for objective and quantitative analysis of meibography images. The full architecture of the algorithm can be divided into three steps: (1) segmentation of the tarsal conjunctiva area as the region of interest (ROI); (2) segmentation and identification of glands within the ROI; and (3) quantitative multi-parametric analysis including newly defined gland diameter deformation index (DI), gland tortuosity index (TI), and glands signal index (SI). To evaluate the performance of the automated algorithm, the similarity index (k) and the segmentation error including the false positive rate (r_P) and the false negative rate (r_N) are calculated between the manually defined ground truth and the automatic segmentations of both the ROI and meibomian glands of 15 typical meibography images. The feasibility of the algorithm is demonstrated in analyzing typical meibograhy images.