An automated and multi-parametric algorithm for objective analysis of meibography images
This work addresses a domain-specific need for ophthalmologists by providing an objective tool for MGD diagnosis, though it appears incremental as it builds on existing imaging techniques.
The researchers tackled the problem of low repeatability and efficiency in analyzing meibography images for meibomian gland dysfunction by developing an automated, multi-parametric algorithm, achieving evaluation with similarity index and segmentation error rates on 15 images.
Meibography is a non-contact imaging technique used by ophthalmologists to assist in the evaluation and diagnosis of meibomian gland dysfunction (MGD). While artificial qualitative analysis of meibography images could lead to low repeatability and efficiency and multi-parametric analysis is demanding to offer more comprehensive information in discovering subtle changes of meibomian glands during MGD progression, we developed an automated and multi-parametric algorithm for objective and quantitative analysis of meibography images. The full architecture of the algorithm can be divided into three steps: (1) segmentation of the tarsal conjunctiva area as the region of interest (ROI); (2) segmentation and identification of glands within the ROI; and (3) quantitative multi-parametric analysis including newly defined gland diameter deformation index (DI), gland tortuosity index (TI), and glands signal index (SI). To evaluate the performance of the automated algorithm, the similarity index (k) and the segmentation error including the false positive rate (r_P) and the false negative rate (r_N) are calculated between the manually defined ground truth and the automatic segmentations of both the ROI and meibomian glands of 15 typical meibography images. The feasibility of the algorithm is demonstrated in analyzing typical meibograhy images.