Zidong Wang

Yifan Pu, Yiru Wang, Zhuofan Xia et al. · tsinghua

Rotated object detection aims to identify and locate objects in images with arbitrary orientation. In this scenario, the oriented directions of objects vary considerably across different images, while multiple orientations of objects exist within an image. This intrinsic characteristic makes it challenging for standard backbone networks to extract high-quality features of these arbitrarily orientated objects. In this paper, we present Adaptive Rotated Convolution (ARC) module to handle the aforementioned challenges. In our ARC module, the convolution kernels rotate adaptively to extract object features with varying orientations in different images, and an efficient conditional computation mechanism is introduced to accommodate the large orientation variations of objects within an image. The two designs work seamlessly in rotated object detection problem. Moreover, ARC can conveniently serve as a plug-and-play module in various vision backbones to boost their representation ability to detect oriented objects accurately. Experiments on commonly used benchmarks (DOTA and HRSC2016) demonstrate that equipped with our proposed ARC module in the backbone network, the performance of multiple popular oriented object detectors is significantly improved (\eg +3.03\% mAP on Rotated RetinaNet and +4.16\% on CFA). Combined with the highly competitive method Oriented R-CNN, the proposed approach achieves state-of-the-art performance on the DOTA dataset with 81.77\% mAP. Code is available at \url{https://github.com/LeapLabTHU/ARC}.

Sirui Liu, Jun Zhang, Haotian Chu et al.

Proteins are essential component of human life and their structures are important for function and mechanism analysis. Recent work has shown the potential of AI-driven methods for protein structure prediction. However, the development of new models is restricted by the lack of dataset and benchmark training procedure. To the best of our knowledge, the existing open source datasets are far less to satisfy the needs of modern protein sequence-structure related research. To solve this problem, we present the first million-level protein structure prediction dataset with high coverage and diversity, named as PSP. This dataset consists of 570k true structure sequences (10TB) and 745k complementary distillation sequences (15TB). We provide in addition the benchmark training procedure for SOTA protein structure prediction model on this dataset. We validate the utility of this dataset for training by participating CAMEO contest in which our model won the first place. We hope our PSP dataset together with the training benchmark can enable a broader community of AI/biology researchers for AI-driven protein related research.

Chengxuan Qin, Rui Yang, Wenlong You et al.

The increasing number of dispersed EEG dataset publications and the advancement of large-scale Electroencephalogram (EEG) models have increased the demand for practical tools to manage diverse EEG datasets. However, the inherent complexity of EEG data, characterized by variability in content data, metadata, and data formats, poses challenges for integrating multiple datasets and conducting large-scale EEG model research. To tackle the challenges, this paper introduces EEGUnity, an open-source tool that incorporates modules of 'EEG Parser', 'Correction', 'Batch Processing', and 'Large Language Model Boost'. Leveraging the functionality of such modules, EEGUnity facilitates the efficient management of multiple EEG datasets, such as intelligent data structure inference, data cleaning, and data unification. In addition, the capabilities of EEGUnity ensure high data quality and consistency, providing a reliable foundation for large-scale EEG data research. EEGUnity is evaluated across 25 EEG datasets from different sources, offering several typical batch processing workflows. The results demonstrate the high performance and flexibility of EEGUnity in parsing and data processing. The project code is publicly available at github.com/Baizhige/EEGUnity.

Jiahao Huang, Yingying Fang, Yang Nan et al.

Research studies have shown no qualms about using data driven deep learning models for downstream tasks in medical image analysis, e.g., anatomy segmentation and lesion detection, disease diagnosis and prognosis, and treatment planning. However, deep learning models are not the sovereign remedy for medical image analysis when the upstream imaging is not being conducted properly (with artefacts). This has been manifested in MRI studies, where the scanning is typically slow, prone to motion artefacts, with a relatively low signal to noise ratio, and poor spatial and/or temporal resolution. Recent studies have witnessed substantial growth in the development of deep learning techniques for propelling fast MRI. This article aims to (1) introduce the deep learning based data driven techniques for fast MRI including convolutional neural network and generative adversarial network based methods, (2) survey the attention and transformer based models for speeding up MRI reconstruction, and (3) detail the research in coupling physics and data driven models for MRI acceleration. Finally, we will demonstrate through a few clinical applications, explain the importance of data harmonisation and explainable models for such fast MRI techniques in multicentre and multi-scanner studies, and discuss common pitfalls in current research and recommendations for future research directions.

Wendong Bi, Bingbing Xu, Xiaoqian Sun et al.

Company financial risk is ubiquitous and early risk assessment for listed companies can avoid considerable losses. Traditional methods mainly focus on the financial statements of companies and lack the complex relationships among them. However, the financial statements are often biased and lagged, making it difficult to identify risks accurately and timely. To address the challenges, we redefine the problem as \textbf{company financial risk assessment on tribe-style graph} by taking each listed company and its shareholders as a tribe and leveraging financial news to build inter-tribe connections. Such tribe-style graphs present different patterns to distinguish risky companies from normal ones. However, most nodes in the tribe-style graph lack attributes, making it difficult to directly adopt existing graph learning methods (e.g., Graph Neural Networks(GNNs)). In this paper, we propose a novel Hierarchical Graph Neural Network (TH-GNN) for Tribe-style graphs via two levels, with the first level to encode the structure pattern of the tribes with contrastive learning, and the second level to diffuse information based on the inter-tribe relations, achieving effective and efficient risk assessment. Extensive experiments on the real-world company dataset show that our method achieves significant improvements on financial risk assessment over previous competing methods. Also, the extensive ablation studies and visualization comprehensively show the effectiveness of our method.

Jun Zhang, Sirui Liu, Mengyun Chen et al.

Data-driven predictive methods which can efficiently and accurately transform protein sequences into biologically active structures are highly valuable for scientific research and medical development. Determining accurate folding landscape using co-evolutionary information is fundamental to the success of modern protein structure prediction methods. As the state of the art, AlphaFold2 has dramatically raised the accuracy without performing explicit co-evolutionary analysis. Nevertheless, its performance still shows strong dependence on available sequence homologs. Based on the interrogation on the cause of such dependence, we presented EvoGen, a meta generative model, to remedy the underperformance of AlphaFold2 for poor MSA targets. By prompting the model with calibrated or virtually generated homologue sequences, EvoGen helps AlphaFold2 fold accurately in low-data regime and even achieve encouraging performance with single-sequence predictions. Being able to make accurate predictions with few-shot MSA not only generalizes AlphaFold2 better for orphan sequences, but also democratizes its use for high-throughput applications. Besides, EvoGen combined with AlphaFold2 yields a probabilistic structure generation method which could explore alternative conformations of protein sequences, and the task-aware differentiable algorithm for sequence generation will benefit other related tasks including protein design.

Nchongmaje Ndipenoch, Alina Miron, Zidong Wang et al.

Many eye diseases like Diabetic Macular Edema (DME), Age-related Macular Degeneration (AMD), and Glaucoma manifest in the retina, can cause irreversible blindness or severely impair the central version. The Optical Coherence Tomography (OCT), a 3D scan of the retina with high qualitative information about the retinal morphology, can be used to diagnose and monitor changes in the retinal anatomy. Many Deep Learning (DL) methods have shared the success of developing an automated tool to monitor pathological changes in the retina. However, the success of these methods depend mainly on large datasets. To address the challenge from very small and limited datasets, we proposed a DL architecture termed CoNet (Coherent Network) for joint segmentation of layers and fluids in retinal OCT images on very small datasets (less than a hundred training samples). The proposed model was evaluated on the publicly available Duke DME dataset consisting of 110 B-Scans from 10 patients suffering from DME. Experimental results show that the proposed model outperformed both the human experts' annotation and the current state-of-the-art architectures by a clear margin with a mean Dice Score of 88% when trained on 55 images without any data augmentation.

Nchongmaje Ndipenoch, Alina Miron, Zidong Wang et al.

Retinal Optical Coherence Tomography (OCT), a noninvasive cross-sectional scan of the eye with qualitative 3D visualization of the retinal anatomy is use to study the retinal structure and the presence of pathogens. The advent of the retinal OCT has transformed ophthalmology and it is currently paramount for the diagnosis, monitoring and treatment of many eye pathogens including Macular Edema which impairs vision severely or Glaucoma that can cause irreversible blindness. However the quality of retinal OCT images varies among device manufacturers. Deep Learning methods have had their success in the medical image segmentation community but it is still not clear if the level of success can be generalised across OCT images collected from different device vendors. In this work we propose two variants of the nnUNet [8]. The standard nnUNet and an enhanced vision call nnUnet_RASPP (nnU-Net with residual and Atrous Spatial Pyramid Pooling) both of which are robust and generalise with consistent high performance across images from multiple device vendors. The algorithm was validated on the MICCAI 2017 RETOUCH challenge dataset [1] acquired from 3 device vendors across 3 medical centers from patients suffering from 2 retinal disease types. Experimental results show that our algorithms outperform the current state-of-the-arts algorithms by a clear margin for segmentation obtaining a mean Dice Score (DS) of 82.3% for the 3 retinal fluids scoring 84.0%, 80.0%, 83.0% for Intraretinal Fluid (IRF), Subretinal Fluid (SRF), and Pigment Epithelium Detachments (PED) respectively on the testing dataset. Also we obtained a perfect Area Under the Curve (AUC) score of 100% for the detection of the presence of fluid for all 3 fluid classes on the testing dataset.

Zeyu Lu, Zidong Wang, Di Huang et al.

Nature is infinitely resolution-free. In the context of this reality, existing diffusion models, such as Diffusion Transformers, often face challenges when processing image resolutions outside of their trained domain. To overcome this limitation, we present the Flexible Vision Transformer (FiT), a transformer architecture specifically designed for generating images with unrestricted resolutions and aspect ratios. Unlike traditional methods that perceive images as static-resolution grids, FiT conceptualizes images as sequences of dynamically-sized tokens. This perspective enables a flexible training strategy that effortlessly adapts to diverse aspect ratios during both training and inference phases, thus promoting resolution generalization and eliminating biases induced by image cropping. Enhanced by a meticulously adjusted network structure and the integration of training-free extrapolation techniques, FiT exhibits remarkable flexibility in resolution extrapolation generation. Comprehensive experiments demonstrate the exceptional performance of FiT across a broad range of resolutions, showcasing its effectiveness both within and beyond its training resolution distribution. Repository available at https://github.com/whlzy/FiT.

Xiang Huang, Zhuoyuan Li, Hongsheng Liu et al.

Recently, using neural networks to simulate spatio-temporal dynamics has received a lot of attention. However, most existing methods adopt pure data-driven black-box models, which have limited accuracy and interpretability. By combining trainable difference operators with black-box models, we propose a new hybrid architecture explicitly embedded with partial prior knowledge of the underlying PDEs named PDE-Net++. Furthermore, we introduce two distinct options called the trainable flipping difference layer (TFDL) and the trainable dynamic difference layer (TDDL) for the difference operators. Numerous numerical experiments have demonstrated that PDE-Net++ has superior prediction accuracy and better extrapolation performance than black-box models.

Hongyang Wei, Baixin Xu, Hongbo Liu et al.

Recent advances in multimodal models have demonstrated impressive capabilities in unified image generation and editing. However, many prominent open-source models prioritize scaling model parameters over optimizing training strategies, limiting their efficiency and performance. In this work, we present UniPic2-SD3.5M-Kontext, a 2B-parameter DiT model based on SD3.5-Medium, which achieves state-of-the-art image generation and editing while extending seamlessly into a unified multimodal framework. Our approach begins with architectural modifications to SD3.5-Medium and large-scale pre-training on high-quality data, enabling joint text-to-image generation and editing capabilities. To enhance instruction following and editing consistency, we propose a novel Progressive Dual-Task Reinforcement strategy (PDTR), which effectively strengthens both tasks in a staged manner. We empirically validate that the reinforcement phases for different tasks are mutually beneficial and do not induce negative interference. After pre-training and reinforcement strategies, UniPic2-SD3.5M-Kontext demonstrates stronger image generation and editing capabilities than models with significantly larger generation parameters-including BAGEL (7B) and Flux-Kontext (12B). Furthermore, following the MetaQuery, we connect the UniPic2-SD3.5M-Kontext and Qwen2.5-VL-7B via a connector and perform joint training to launch a unified multimodal model UniPic2-Metaquery. UniPic2-Metaquery integrates understanding, generation, and editing, achieving top-tier performance across diverse tasks with a simple and scalable training paradigm. This consistently validates the effectiveness and generalizability of our proposed training paradigm, which we formalize as Skywork UniPic 2.0.

Xiang Huang, Zhanhong Ye, Hongsheng Liu et al.

Many important problems in science and engineering require solving the so-called parametric partial differential equations (PDEs), i.e., PDEs with different physical parameters, boundary conditions, shapes of computation domains, etc. Recently, building learning-based numerical solvers for parametric PDEs has become an emerging new field. One category of methods such as the Deep Galerkin Method (DGM) and Physics-Informed Neural Networks (PINNs) aim to approximate the solution of the PDEs. They are typically unsupervised and mesh-free, but require going through the time-consuming network training process from scratch for each set of parameters of the PDE. Another category of methods such as Fourier Neural Operator (FNO) and Deep Operator Network (DeepONet) try to approximate the solution mapping directly. Being fast with only one forward inference for each PDE parameter without retraining, they often require a large corpus of paired input-output observations drawn from numerical simulations, and most of them need a predefined mesh as well. In this paper, we propose Meta-Auto-Decoder (MAD), a mesh-free and unsupervised deep learning method that enables the pre-trained model to be quickly adapted to equation instances by implicitly encoding (possibly heterogenous) PDE parameters as latent vectors. The proposed method MAD can be interpreted by manifold learning in infinite-dimensional spaces, granting it a geometric insight. Extensive numerical experiments show that the MAD method exhibits faster convergence speed without losing accuracy than other deep learning-based methods. The project page with code is available: https://gitee.com/mindspore/mindscience/tree/master/MindElec/.

Zhihao Cao, Zidong Wang, Siwen Xie et al.

Despite the significant demand for assistive technology among vulnerable groups (e.g., the elderly, children, and the disabled) in daily tasks, research into advanced AI-driven assistive solutions that genuinely accommodate their diverse needs remains sparse. Traditional human-machine interaction tasks often require machines to simply help without nuanced consideration of human abilities and feelings, such as their opportunity for practice and learning, sense of self-improvement, and self-esteem. Addressing this gap, we define a pivotal and novel challenge Smart Help, which aims to provide proactive yet adaptive support to human agents with diverse disabilities and dynamic goals in various tasks and environments. To establish this challenge, we leverage AI2-THOR to build a new interactive 3D realistic household environment for the Smart Help task. We introduce an innovative opponent modeling module that provides a nuanced understanding of the main agent's capabilities and goals, in order to optimize the assisting agent's helping policy. Rigorous experiments validate the efficacy of our model components and show the superiority of our holistic approach against established baselines. Our findings illustrate the potential of AI-imbued assistive robots in improving the well-being of vulnerable groups.

Zidong Wang, Lei Bai, Xiangyu Yue et al.

We introduce native-resolution image synthesis, a novel generative modeling paradigm that enables the synthesis of images at arbitrary resolutions and aspect ratios. This approach overcomes the limitations of conventional fixed-resolution, square-image methods by natively handling variable-length visual tokens, a core challenge for traditional techniques. To this end, we introduce the Native-resolution diffusion Transformer (NiT), an architecture designed to explicitly model varying resolutions and aspect ratios within its denoising process. Free from the constraints of fixed formats, NiT learns intrinsic visual distributions from images spanning a broad range of resolutions and aspect ratios. Notably, a single NiT model simultaneously achieves the state-of-the-art performance on both ImageNet-256x256 and 512x512 benchmarks. Surprisingly, akin to the robust zero-shot capabilities seen in advanced large language models, NiT, trained solely on ImageNet, demonstrates excellent zero-shot generalization performance. It successfully generates high-fidelity images at previously unseen high resolutions (e.g., 1536 x 1536) and diverse aspect ratios (e.g., 16:9, 3:1, 4:3), as shown in Figure 1. These findings indicate the significant potential of native-resolution modeling as a bridge between visual generative modeling and advanced LLM methodologies.

Zhige Chen, Rui Yang, Mengjie Huang et al.

Because of "the non-repeatability of the experiment settings and conditions" and "the variability of brain patterns among subjects", the data distributions across sessions and electrodes are different in cross-subject motor imagery (MI) studies, eventually reducing the performance of the classification model. Systematically summarised based on the existing studies, a novel temporal-electrode data distribution problem is investigated under both intra-subject and inter-subject scenarios in this paper. Based on the presented issue, a novel bridging domain adaptation network (BDAN) is proposed, aiming to minimise the data distribution difference across sessions in the aspect of the electrode, thus improving and enhancing model performance. In the proposed BDAN, deep features of all the EEG data are extracted via a specially designed spatial feature extractor. With the obtained spatio-temporal features, a special generative bridging domain is established, bridging the data from all the subjects across sessions. The difference across sessions and electrodes is then minimized using the customized bridging loss functions, and the known knowledge is automatically transferred through the constructed bridging domain. To show the effectiveness of the proposed BDAN, comparison experiments and ablation studies are conducted on a public EEG dataset. The overall comparison results demonstrate the superior performance of the proposed BDAN compared with the other advanced deep learning and domain adaptation methods.

YaoDan Zhang, Zidong Wang, Ru Jia et al.

In recent years, personalized recommendation technology has flourished and become one of the hot research directions. The matrix factorization model and the metric learning model which proposed successively have been widely studied and applied. The latter uses the Euclidean distance instead of the dot product used by the former to measure the latent space vector. While avoiding the shortcomings of the dot product, the assumption of Euclidean distance is neglected, resulting in limited recommendation quality of the model. In order to solve this problem, this paper combines the Variationl Information Bottleneck with metric learning model for the first time, and proposes a new metric learning model VIB-DML (Variational Information Bottleneck Distance Metric Learning) for rating prediction, which limits the mutual information of the latent space feature vector to improve the robustness of the model and satisfiy the assumption of Euclidean distance by decoupling the latent space feature vector. In this paper, the experimental results are compared with the root mean square error (RMSE) on the three public datasets. The results show that the generalization ability of VIB-DML is excellent. Compared with the general metric learning model MetricF, the prediction error is reduced by 7.29%. Finally, the paper proves the strong robustness of VIBDML through experiments.

Xiang Huang, Hongsheng Liu, Beiji Shi et al.

In recent years, deep learning technology has been used to solve partial differential equations (PDEs), among which the physics-informed neural networks (PINNs) emerges to be a promising method for solving both forward and inverse PDE problems. PDEs with a point source that is expressed as a Dirac delta function in the governing equations are mathematical models of many physical processes. However, they cannot be solved directly by conventional PINNs method due to the singularity brought by the Dirac delta function. We propose a universal solution to tackle this problem with three novel techniques. Firstly the Dirac delta function is modeled as a continuous probability density function to eliminate the singularity; secondly a lower bound constrained uncertainty weighting algorithm is proposed to balance the PINNs losses between point source area and other areas; and thirdly a multi-scale deep neural network with periodic activation function is used to improve the accuracy and convergence speed of the PINNs method. We evaluate the proposed method with three representative PDEs, and the experimental results show that our method outperforms existing deep learning-based methods with respect to the accuracy, the efficiency and the versatility.

Zedong Tang, Fenlong Jiang, Junke Song et al.

Optimizers that further adjust the scale of gradient, such as Adam, Natural Gradient (NG), etc., despite widely concerned and used by the community, are often found poor generalization performance, compared with Stochastic Gradient Descent (SGD). They tend to converge excellently at the beginning of training but are weak at the end. An immediate idea is to complement the strengths of these algorithms with SGD. However, a truncated replacement of optimizer often leads to a crash of the update pattern, and new algorithms often require many iterations to stabilize their search direction. Driven by this idea and to address this problem, we design and present a regularized natural gradient optimization algorithm with look-ahead strategy, named asymptotic natural gradient (ANG). According to the total iteration step, ANG dynamic assembles NG and Euclidean gradient, and updates parameters along the new direction using the intensity of NG. Validation experiments on CIFAR10 and CIFAR100 data sets show that ANG can update smoothly and stably at the second-order speed, and achieve better generalization performance.

Kai-Xin Gao, Xiao-Lei Liu, Zheng-Hai Huang et al.

Using second-order optimization methods for training deep neural networks (DNNs) has attracted many researchers. A recently proposed method, Eigenvalue-corrected Kronecker Factorization (EKFAC) (George et al., 2018), proposes an interpretation of viewing natural gradient update as a diagonal method, and corrects the inaccurate re-scaling factor in the Kronecker-factored eigenbasis. Gao et al. (2020) considers a new approximation to the natural gradient, which approximates the Fisher information matrix (FIM) to a constant multiplied by the Kronecker product of two matrices and keeps the trace equal before and after the approximation. In this work, we combine the ideas of these two methods and propose Trace-restricted Eigenvalue-corrected Kronecker Factorization (TEKFAC). The proposed method not only corrects the inexact re-scaling factor under the Kronecker-factored eigenbasis, but also considers the new approximation method and the effective damping technique proposed in Gao et al. (2020). We also discuss the differences and relationships among the Kronecker-factored approximations. Empirically, our method outperforms SGD with momentum, Adam, EKFAC and TKFAC on several DNNs.

Kai-Xin Gao, Xiao-Lei Liu, Zheng-Hai Huang et al.

Second-order optimization methods have the ability to accelerate convergence by modifying the gradient through the curvature matrix. There have been many attempts to use second-order optimization methods for training deep neural networks. Inspired by diagonal approximations and factored approximations such as Kronecker-Factored Approximate Curvature (KFAC), we propose a new approximation to the Fisher information matrix (FIM) called Trace-restricted Kronecker-factored Approximate Curvature (TKFAC) in this work, which can hold the certain trace relationship between the exact and the approximate FIM. In TKFAC, we decompose each block of the approximate FIM as a Kronecker product of two smaller matrices and scaled by a coefficient related to trace. We theoretically analyze TKFAC's approximation error and give an upper bound of it. We also propose a new damping technique for TKFAC on convolutional neural networks to maintain the superiority of second-order optimization methods during training. Experiments show that our method has better performance compared with several state-of-the-art algorithms on some deep network architectures.