David Liu

Yuzhen Ding, Hongying Feng, Yunze Yang et al.

Purpose: In some proton therapy facilities, patient alignment relies on two 2D orthogonal kV images, taken at fixed, oblique angles, as no 3D on-the-bed imaging is available. The visibility of the tumor in kV images is limited since the patient's 3D anatomy is projected onto a 2D plane, especially when the tumor is behind high-density structures such as bones. This can lead to large patient setup errors. A solution is to reconstruct the 3D CT image from the kV images obtained at the treatment isocenter in the treatment position. Methods: An asymmetric autoencoder-like network built with vision-transformer blocks was developed. The data was collected from 1 head and neck patient: 2 orthogonal kV images (1024x1024 voxels), 1 3D CT with padding (512x512x512) acquired from the in-room CT-on-rails before kVs were taken and 2 digitally-reconstructed-radiograph (DRR) images (512x512) based on the CT. We resampled kV images every 8 voxels and DRR and CT every 4 voxels, thus formed a dataset consisting of 262,144 samples, in which the images have a dimension of 128 for each direction. In training, both kV and DRR images were utilized, and the encoder was encouraged to learn the jointed feature map from both kV and DRR images. In testing, only independent kV images were used. The full-size synthetic CT (sCT) was achieved by concatenating the sCTs generated by the model according to their spatial information. The image quality of the synthetic CT (sCT) was evaluated using mean absolute error (MAE) and per-voxel-absolute-CT-number-difference volume histogram (CDVH). Results: The model achieved a speed of 2.1s and a MAE of <40HU. The CDVH showed that <5% of the voxels had a per-voxel-absolute-CT-number-difference larger than 185 HU. Conclusion: A patient-specific vision-transformer-based network was developed and shown to be accurate and efficient to reconstruct 3D CT images from kV images.

Xu Liu, Mengyue Zhou, Gaosheng Shi et al.

Linking computational natural language processing (NLP) models and neural responses to language in the human brain on the one hand facilitates the effort towards disentangling the neural representations underpinning language perception, on the other hand provides neurolinguistics evidence to evaluate and improve NLP models. Mappings of an NLP model's representations of and the brain activities evoked by linguistic input are typically deployed to reveal this symbiosis. However, two critical problems limit its advancement: 1) The model's representations (artificial neurons, ANs) rely on layer-level embeddings and thus lack fine-granularity; 2) The brain activities (biological neurons, BNs) are limited to neural recordings of isolated cortical unit (i.e., voxel/region) and thus lack integrations and interactions among brain functions. To address those problems, in this study, we 1) define ANs with fine-granularity in transformer-based NLP models (BERT in this study) and measure their temporal activations to input text sequences; 2) define BNs as functional brain networks (FBNs) extracted from functional magnetic resonance imaging (fMRI) data to capture functional interactions in the brain; 3) couple ANs and BNs by maximizing the synchronization of their temporal activations. Our experimental results demonstrate 1) The activations of ANs and BNs are significantly synchronized; 2) the ANs carry meaningful linguistic/semantic information and anchor to their BN signatures; 3) the anchored BNs are interpretable in a neurolinguistic context. Overall, our study introduces a novel, general, and effective framework to link transformer-based NLP models and neural activities in response to language and may provide novel insights for future studies such as brain-inspired evaluation and development of NLP models.

David Liu, Zhengkun Li, Zihao Wu et al.

Robotic crop phenotyping has emerged as a key technology to assess crops' morphological and physiological traits at scale. These phenotypical measurements are essential for developing new crop varieties with the aim of increasing productivity and dealing with environmental challenges such as climate change. However, developing and deploying crop phenotyping robots face many challenges such as complex and variable crop shapes that complicate robotic object detection, dynamic and unstructured environments that baffle robotic control, and real-time computing and managing big data that challenge robotic hardware/software. This work specifically tackles the first challenge by proposing a novel Digital-Twin(DT)MARS-CycleGAN model for image augmentation to improve our Modular Agricultural Robotic System (MARS)'s crop object detection from complex and variable backgrounds. Our core idea is that in addition to the cycle consistency losses in the CycleGAN model, we designed and enforced a new DT-MARS loss in the deep learning model to penalize the inconsistency between real crop images captured by MARS and synthesized images sensed by DT MARS. Therefore, the generated synthesized crop images closely mimic real images in terms of realism, and they are employed to fine-tune object detectors such as YOLOv8. Extensive experiments demonstrated that our new DT/MARS-CycleGAN framework significantly boosts our MARS' crop object/row detector's performance, contributing to the field of robotic crop phenotyping.

David Liu, Jackie Baek, Tina Eliassi-Rad

We study the fairness of dimensionality reduction methods for recommendations. We focus on the fundamental method of principal component analysis (PCA), which identifies latent components and produces a low-rank approximation via the leading components while discarding the trailing components. Prior works have defined notions of "fair PCA"; however, these definitions do not answer the following question: why is PCA unfair? We identify two underlying popularity mechanisms that induce item unfairness in PCA. The first negatively impacts less popular items because less popular items rely on trailing latent components to recover their values. The second negatively impacts highly popular items, since the leading PCA components specialize in individual popular items instead of capturing similarities between items. To address these issues, we develop a polynomial-time algorithm, Item-Weighted PCA, that flexibly up-weights less popular items when optimizing for leading principal components. We theoretically show that PCA, in all cases, and Normalized PCA, in cases of block-diagonal matrices, are instances of Item-Weighted PCA. We empirically show that there exist datasets for which Item-Weighted PCA yields the optimal solution while the baselines do not. In contrast to past dimensionality reduction re-weighting techniques, Item-Weighted PCA solves a convex optimization problem and enforces a hard rank constraint. Our evaluations on real-world datasets show that Item-Weighted PCA not only mitigates both unfairness mechanisms, but also produces recommendations that outperform those of PCA baselines.

Samantha Dies, David Liu, Tina Eliassi-Rad

Faculty hiring shapes the flow of ideas, resources, and opportunities in academia, influencing not only individual career trajectories but also broader patterns of institutional prestige and scientific progress. While traditional studies have found strong correlations between faculty hiring and attributes such as doctoral department prestige and publication record, they rarely assess whether these associations generalize to individual hiring outcomes, particularly for future candidates outside the original sample. Here, we consider faculty placement as an individual-level prediction task. Our data consist of temporal co-authorship networks with conventional attributes such as doctoral department prestige and bibliometric features. We observe that using the co-authorship network significantly improves predictive accuracy by up to 10% over traditional indicators alone, with the largest gains observed for placements at the most elite (top-10) departments. Our results underscore the role that social networks, professional endorsements, and implicit advocacy play in faculty hiring beyond traditional measures of scholarly productivity and institutional prestige. By introducing a predictive framing of faculty placement and establishing the benefit of considering co-authorship networks, this work provides a new lens for understanding structural biases in academia that could inform targeted interventions aimed at increasing transparency, fairness, and equity in academic hiring practices.

Alvin Kimbowa, Arjun Parmar, Maziar Badii et al.

Automated knee cartilage segmentation using point-of-care ultrasound devices and deep-learning networks has the potential to enhance the management of knee osteoarthritis. However, segmentation algorithms often struggle with domain shifts caused by variations in ultrasound devices and acquisition parameters, limiting their generalizability. In this paper, we propose Mono2D, a monogenic layer that extracts multi-scale, contrast- and intensity-invariant local phase features using trainable bandpass quadrature filters. This layer mitigates domain shifts, improving generalization to out-of-distribution domains. Mono2D is integrated before the first layer of a segmentation network, and its parameters jointly trained alongside the network's parameters. We evaluated Mono2D on a multi-domain 2D ultrasound knee cartilage dataset for single-source domain generalization (SSDG). Our results demonstrate that Mono2D outperforms other SSDG methods in terms of Dice score and mean average surface distance. To further assess its generalizability, we evaluate Mono2D on a multi-site prostate MRI dataset, where it continues to outperform other SSDG methods, highlighting its potential to improve domain generalization in medical imaging. Nevertheless, further evaluation on diverse datasets is still necessary to assess its clinical utility.