Delong Yang

Xiang Yu, Yayan Chen, Guannan He et al.

While modern segmentation models often prioritize performance over practicality, we advocate a design philosophy prioritizing simplicity and efficiency, and attempted high performance segmentation model design. This paper presents SimpleUNet, a scalable ultra-lightweight medical image segmentation model with three key innovations: (1) A partial feature selection mechanism in skip connections for redundancy reduction while enhancing segmentation performance; (2) A fixed-width architecture that prevents exponential parameter growth across network stages; (3) An adaptive feature fusion module achieving enhanced representation with minimal computational overhead. With a record-breaking 16 KB parameter configuration, SimpleUNet outperforms LBUNet and other lightweight benchmarks across multiple public datasets. The 0.67 MB variant achieves superior efficiency (8.60 GFLOPs) and accuracy, attaining a mean DSC/IoU of 85.76%/75.60% on multi-center breast lesion datasets, surpassing both U-Net and TransUNet. Evaluations on skin lesion datasets (ISIC 2017/2018: mDice 84.86%/88.77%) and endoscopic polyp segmentation (KVASIR-SEG: 86.46%/76.48% mDice/mIoU) confirm consistent dominance over state-of-the-art models. This work demonstrates that extreme model compression need not compromise performance, providing new insights for efficient and accurate medical image segmentation. Codes can be found at https://github.com/Frankyu5666666/SimpleUNet.

Tianli Tao, Ziyang Wang, Delong Yang et al.

Longitudinal brain MRI is essential for lifespan study, yet high attrition rates often lead to missing data, complicating analysis. Deep generative models have been explored, but most rely solely on image intensity, leading to two key limitations: 1) the fidelity or trustworthiness of the generated brain images are limited, making downstream studies questionable; 2) the usage flexibility is restricted due to fixed guidance rooted in the model structure, restricting full ability to versatile application scenarios. To address these challenges, we introduce DF-DiffCom, a Kolmogorov-Arnold Networks (KAN)-enhanced diffusion model that smartly leverages deformation fields for trustworthy longitudinal brain image completion. Trained on OASIS-3, DF-DiffCom outperforms state-of-the-art methods, improving PSNR by 5.6% and SSIM by 0.12. More importantly, its modality-agnostic nature allows smooth extension to varied MRI modalities, even to attribute maps such as brain tissue segmentation results.

Ruiqing Sun, Delong Yang, Shaohui Zhang et al.

Relying on either deep models or physical models are two mainstream approaches for solving inverse sample reconstruction problems in programmable illumination computational microscopy. Solutions based on physical models possess strong generalization capabilities while struggling with global optimization of inverse problems due to a lack of insufficient physical constraints. In contrast, deep learning methods have strong problem-solving abilities, but their generalization ability is often questioned because of the unclear physical principles. Besides, conventional deep models are difficult to apply to some specific scenes because of the difficulty in acquiring high-quality training data and their limited capacity to generalize across different scenarios. In this paper, to combine the advantages of deep models and physical models together, we propose a hybrid framework consisting of three sub-neural networks (two deep learning networks and one physics-based network). We first obtain a result with rich semantic information through a light deep learning neural network and then use it as the initial value of the physical network to make its output comply with physical process constraints. These two results are then used as the input of a fusion deep learning neural work which utilizes the paired features between the reconstruction results of two different models to further enhance imaging quality. The final result integrates the advantages of both deep models and physical models and can quickly solve the computational reconstruction inverse problem in programmable illumination computational microscopy and achieve better results. We verified the feasibility and effectiveness of the proposed hybrid framework with theoretical analysis and actual experiments on resolution targets and biological samples.