Ralf Mikut

Simon Graham, Quoc Dang Vu, Mostafa Jahanifar et al.

Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome. To drive innovation in this area, we setup a community-wide challenge using the largest available dataset of its kind to assess nuclear segmentation and cellular composition. Our challenge, named CoNIC, stimulated the development of reproducible algorithms for cellular recognition with real-time result inspection on public leaderboards. We conducted an extensive post-challenge analysis based on the top-performing models using 1,658 whole-slide images of colon tissue. With around 700 million detected nuclei per model, associated features were used for dysplasia grading and survival analysis, where we demonstrated that the challenge's improvement over the previous state-of-the-art led to significant boosts in downstream performance. Our findings also suggest that eosinophils and neutrophils play an important role in the tumour microevironment. We release challenge models and WSI-level results to foster the development of further methods for biomarker discovery.

Katharina Löffler, Ralf Mikut

A systematic analysis of the cell behavior requires automated approaches for cell segmentation and tracking. While deep learning has been successfully applied for the task of cell segmentation, there are few approaches for simultaneous cell segmentation and tracking using deep learning. Here, we present EmbedTrack, a single convolutional neural network for simultaneous cell segmentation and tracking which predicts easy to interpret embeddings. As embeddings, offsets of cell pixels to their cell center and bandwidths are learned. We benchmark our approach on nine 2D data sets from the Cell Tracking Challenge, where our approach performs on seven out of nine data sets within the top 3 contestants including three top 1 performances. The source code is publicly available at https://git.scc.kit.edu/kit-loe-ge/embedtrack.

Matthias Hertel, Maximilian Beichter, Benedikt Heidrich et al.

In the smart grid of the future, accurate load forecasts on the level of individual clients can help to balance supply and demand locally and to prevent grid outages. While the number of monitored clients will increase with the ongoing smart meter rollout, the amount of data per client will always be limited. We evaluate whether a Transformer load forecasting model benefits from a transfer learning strategy, where a global univariate model is trained on the load time series from multiple clients. In experiments with two datasets containing load time series from several hundred clients, we find that the global training strategy is superior to the multivariate and local training strategies used in related work. On average, the global training strategy results in 21.8% and 12.8% lower forecasting errors than the two other strategies, measured across forecasting horizons from one day to one month into the future. A comparison to linear models, multi-layer perceptrons and LSTMs shows that Transformers are effective for load forecasting when they are trained with the global training strategy.

Jorge Ángel González Ordiano, Wolfgang Doneit, Simon Waczowicz et al.

The present contribution offers a simple methodology for the obtainment of data-driven interval forecasting models by combining pairs of quantile regressions. Those regressions are created without the usage of the non-differentiable pinball-loss function, but through a k-nearest-neighbors based training set transformation and traditional regression approaches. By leaving the underlying training algorithms of the data mining techniques unchanged, the presented approach simplifies the creation of quantile regressions with more complex techniques (e.g. artificial neural networks). The quality of the presented methodology is tested on the usecase of photovoltaic power forecasting, for which quantile regressions using polynomial models as well as artificial neural networks and support vector regressions are created. From the resulting evaluation values it can be concluded that acceptable interval forecasting models are created.

Stefan Meisenbacher, Benedikt Heidrich, Tim Martin et al.

Accurate PhotoVoltaic (PV) power generation forecasting is vital for the efficient operation of Smart Grids. The automated design of such accurate forecasting models for individual PV plants includes two challenges: First, information about the PV mounting configuration (i.e. inclination and azimuth angles) is often missing. Second, for new PV plants, the amount of historical data available to train a forecasting model is limited (cold-start problem). We address these two challenges by proposing a new method for day-ahead PV power generation forecasts called AutoPV. AutoPV is a weighted ensemble of forecasting models that represent different PV mounting configurations. This representation is achieved by pre-training each forecasting model on a separate PV plant and by scaling the model's output with the peak power rating of the corresponding PV plant. To tackle the cold-start problem, we initially weight each forecasting model in the ensemble equally. To tackle the problem of missing information about the PV mounting configuration, we use new data that become available during operation to adapt the ensemble weights to minimize the forecasting error. AutoPV is advantageous as the unknown PV mounting configuration is implicitly reflected in the ensemble weights, and only the PV plant's peak power rating is required to re-scale the ensemble's output. AutoPV also allows to represent PV plants with panels distributed on different roofs with varying alignments, as these mounting configurations can be reflected proportionally in the weighting. Additionally, the required computing memory is decoupled when scaling AutoPV to hundreds of PV plants, which is beneficial in Smart Grids with limited computing capabilities. For a real-world data set with 11 PV plants, the accuracy of AutoPV is comparable to a model trained on two years of data and outperforms an incrementally trained model.

David Bethge, Philipp Hallgarten, Ozan Özdenizci et al.

Electroencephalography (EEG) is shown to be a valuable data source for evaluating subjects' mental states. However, the interpretation of multi-modal EEG signals is challenging, as they suffer from poor signal-to-noise-ratio, are highly subject-dependent, and are bound to the equipment and experimental setup used, (i.e. domain). This leads to machine learning models often suffer from poor generalization ability, where they perform significantly worse on real-world data than on the exploited training data. Recent research heavily focuses on cross-subject and cross-session transfer learning frameworks to reduce domain calibration efforts for EEG signals. We argue that multi-source learning via learning domain-invariant representations from multiple data-sources is a viable alternative, as the available data from different EEG data-source domains (e.g., subjects, sessions, experimental setups) grow massively. We propose an adversarial inference approach to learn data-source invariant representations in this context, enabling multi-source learning for EEG-based brain-computer interfaces. We unify EEG recordings from different source domains (i.e., emotion recognition datasets SEED, SEED-IV, DEAP, DREAMER), and demonstrate the feasibility of our invariant representation learning approach in suppressing data-source-relevant information leakage by 35% while still achieving stable EEG-based emotion classification performance.

Simon Baeuerle, Marius Gebhardt, Jonas Barth et al.

Thermal Interface Materials (TIMs) are widely used in electronic packaging. Increasing power density and limited assembly space pose high demands on thermal management. Large cooling surfaces need to be covered efficiently. When joining the heatsink, previously dispensed TIM spreads over the cooling surface. Recommendations on the dispensing pattern exist only for simple surface geometries such as rectangles. For more complex geometries, Computational Fluid Dynamics (CFD) simulations are used in combination with manual experiments. While CFD simulations offer a high accuracy, they involve simulation experts and are rather expensive to set up. We propose a lightweight heuristic to model the spreading behavior of TIM. We further speed up the calculation by training an Artificial Neural Network (ANN) on data from this model. This offers rapid computation times and further supplies gradient information. This ANN can not only be used to aid manual pattern design of TIM, but also enables an automated pattern optimization. We compare this approach against the state-of-the-art and use real product samples for validation.

Angelo Yamachui Sitcheu, Nils Friederich, Simon Baeuerle et al.

Nowadays, Machine Learning (ML) is experiencing tremendous popularity that has never been seen before. The operationalization of ML models is governed by a set of concepts and methods referred to as Machine Learning Operations (MLOps). Nevertheless, researchers, as well as professionals, often focus more on the automation aspect and neglect the continuous deployment and monitoring aspects of MLOps. As a result, there is a lack of continuous learning through the flow of feedback from production to development, causing unexpected model deterioration over time due to concept drifts, particularly when dealing with scarce data. This work explores the complete application of MLOps in the context of scarce data analysis. The paper proposes a new holistic approach to enhance biomedical image analysis. Our method includes: a fingerprinting process that enables selecting the best models, datasets, and model development strategy relative to the image analysis task at hand; an automated model development stage; and a continuous deployment and monitoring process to ensure continuous learning. For preliminary results, we perform a proof of concept for fingerprinting in microscopic image datasets.

Thorbjørn Lund Onsaker, Heidi S. Nygård, Damià Gomila et al.

Modelling, forecasting and overall understanding of the dynamics of the power grid and its frequency are essential for the safe operation of existing and future power grids. Much previous research was focused on large continental areas, while small systems, such as islands are less well-studied. These natural island systems are ideal testing environments for microgrid proposals and artificially islanded grid operation. In the present paper, we utilize measurements of the power grid frequency obtained in European islands: the Faroe Islands, Ireland, the Balearic Islands and Iceland and investigate how their frequency can be predicted, compared to the Nordic power system, acting as a reference. The Balearic islands are found to be particularly deterministic and easy to predict in contrast to hard-to-predict Iceland. Furthermore, we show that typically 2-4 weeks of data are needed to improve prediction performance beyond simple benchmarks.

Nicole Merkle, Ralf Mikut

Computational agents support humans in many areas of life and are therefore found in heterogeneous contexts. This means they operate in rapidly changing environments and can be confronted with huge state and action spaces. In order to perform services and carry out activities in a goal-oriented manner, agents require prior knowledge and therefore have to develop and pursue context-dependent policies. However, prescribing policies in advance is limited and inflexible, especially in dynamically changing environments. Moreover, the context of an agent determines its choice of actions. Since the environments can be stochastic and complex in terms of the number of states and feasible actions, activities are usually modelled in a simplified way by Markov decision processes so that, e.g., agents with reinforcement learning are able to learn policies, that help to capture the context and act accordingly to optimally perform activities. However, training policies for all possible contexts using reinforcement learning is time-consuming. A requirement and challenge for agents is to learn strategies quickly and respond immediately in cross-context environments and applications, e.g., the Internet, service robotics, cyber-physical systems. In this work, we propose a novel simulation-based approach that enables a) the representation of heterogeneous contexts through knowledge graphs and entity embeddings and b) the context-aware composition of policies on demand by ensembles of agents running in parallel. The evaluation we conducted with the "Virtual Home" dataset indicates that agents with a need to switch seamlessly between different contexts, can request on-demand composed policies that lead to the successful completion of context-appropriate activities without having to learn these policies in lengthy training steps and episodes, in contrast to agents that use reinforcement learning.

Oliver Neumann, Marcel Schilling, Markus Reischl et al.

Various research domains use machine learning approaches because they can solve complex tasks by learning from data. Deploying machine learning models, however, is not trivial and developers have to implement complete solutions which are often installed locally and include Graphical User Interfaces (GUIs). Distributing software to various users on-site has several problems. Therefore, we propose a concept to deploy software in the cloud. There are several frameworks available based on Representational State Transfer (REST) which can be used to implement cloud-based machine learning services. However, machine learning services for scientific users have special requirements that state-of-the-art REST frameworks do not cover completely. We contribute an EasyMLServe software framework to deploy machine learning services in the cloud using REST interfaces and generic local or web-based GUIs. Furthermore, we apply our framework on two real-world applications, \ie, energy time-series forecasting and cell instance segmentation. The EasyMLServe framework and the use cases are available on GitHub.

Benedikt Heidrich, Kaleb Phipps, Oliver Neumann et al.

Probabilistic forecasts are essential for various downstream applications such as business development, traffic planning, and electrical grid balancing. Many of these probabilistic forecasts are performed on time series data that contain calendar-driven periodicities. However, existing probabilistic forecasting methods do not explicitly take these periodicities into account. Therefore, in the present paper, we introduce a deep learning-based method that considers these calendar-driven periodicities explicitly. The present paper, thus, has a twofold contribution: First, we apply statistical methods that use calendar-driven prior knowledge to create rolling statistics and combine them with neural networks to provide better probabilistic forecasts. Second, we benchmark ProbPNN with state-of-the-art benchmarks by comparing the achieved normalised continuous ranked probability score (nCRPS) and normalised Pinball Loss (nPL) on two data sets containing in total more than 1000 time series. The results of the benchmarks show that using statistical forecasting components improves the probabilistic forecast performance and that ProbPNN outperforms other deep learning forecasting methods whilst requiring less computation costs.

David Exler, Nils Friederich, Martin Krüger et al.

Myotubes are multinucleated muscle fibers serving as key model systems for studying muscle physiology, disease mechanisms, and drug responses. Mechanistic studies and drug screening thereby rely on quantitative morphological readouts such as diameter, length, and branching degree, which in turn require precise three-dimensional instance segmentation. Yet established pretrained biomedical segmentation models fail to generalize to this domain due to the absence of large annotated myotube datasets. We introduce a geometry-driven synthesis pipeline that models individual myotubes via polynomial centerlines, locally varying radii, branching structures, and ellipsoidal end caps derived from real microscopy observations. Synthetic volumes are rendered with realistic noise, optical artifacts, and CycleGAN-based Domain Adaptation (DA). A compact 3D U-Net with self-supervised encoder pretraining, trained exclusively on synthetic data, achieves a mean IPQ of 0.22 on real data, significantly outperforming three established zero-shot segmentation models, demonstrating that biophysics-driven synthesis enables effective instance segmentation in annotation-scarce biomedical domains.

Kaleb Phipps, Benedikt Heidrich, Marian Turowski et al.

In various applications, probabilistic forecasts are required to quantify the inherent uncertainty associated with the forecast. However, numerous modern forecasting methods are still designed to create deterministic forecasts. Transforming these deterministic forecasts into probabilistic forecasts is often challenging and based on numerous assumptions that may not hold in real-world situations. Therefore, the present article proposes a novel approach for creating probabilistic forecasts from arbitrary deterministic forecasts. In order to implement this approach, we use a conditional Invertible Neural Network (cINN). More specifically, we apply a cINN to learn the underlying distribution of the data and then combine the uncertainty from this distribution with an arbitrary deterministic forecast to generate accurate probabilistic forecasts. Our approach enables the simple creation of probabilistic forecasts without complicated statistical loss functions or further assumptions. Besides showing the mathematical validity of our approach, we empirically show that our approach noticeably outperforms traditional methods for including uncertainty in deterministic forecasts and generally outperforms state-of-the-art probabilistic forecasting benchmarks.

Manuel Treutlein, Marc Schmidt, Roman Hahn et al.

Distribution system operators (DSOs) must cope with new challenges such as the reconstruction of distribution grids along climate neutrality pathways or the ability to manage and control consumption and generation in the grid. In order to meet the challenges, measurements within the distribution grid often form the basis for DSOs. Hence, it is an urgent problem that measurement devices are not installed in many low-voltage (LV) grids. In order to overcome this problem, we present an approach to estimate pseudo-measurements for non-measured LV feeders based on the metadata of the respective feeder using regression models. The feeder metadata comprise information about the number of grid connection points, the installed power of consumers and producers, and billing data in the downstream LV grid. Additionally, we use weather data, calendar data and timestamp information as model features. The existing measurements are used as model target. We extensively evaluate the estimated pseudo-measurements on a large real-world dataset with 2,323 LV feeders characterized by both consumption and feed-in. For this purpose, we introduce peak metrics inspired by the BigDEAL challenge for the peak magnitude, timing and shape for both consumption and feed-in. As regression models, we use XGBoost, a multilayer perceptron (MLP) and a linear regression (LR). We observe that XGBoost and MLP outperform the LR. Furthermore, the results show that the approach adapts to different weather, calendar and timestamp conditions and produces realistic load curves based on the feeder metadata. In the future, the approach can be adapted to other grid levels like substation transformers and can supplement research fields like load modeling, state estimation and LV load forecasting.

Pascal Henrich, Jonas Sievers, Maximilian Beichter et al.

Transformer-based reinforcement learning has emerged as a strong candidate for sequential control in residential energy management. In particular, the Decision Transformer can learn effective battery dispatch policies from historical data, thereby increasing photovoltaic self-consumption and reducing electricity costs. However, transformer models are typically too computationally demanding for deployment on resource-constrained residential controllers, where memory and latency constraints are critical. This paper investigates knowledge distillation to transfer the decision-making behaviour of high-capacity Decision Transformer policies to compact models that are more suitable for embedded deployment. Using the Ausgrid dataset, we train teacher models in an offline sequence-based Decision Transformer framework on heterogeneous multi-building data. We then distil smaller student models by matching the teachers' actions, thereby preserving control quality while reducing model size. Across a broad set of teacher-student configurations, distillation largely preserves control performance and even yields small improvements of up to 1%, while reducing the parameter count by up to 96%, the inference memory by up to 90%, and the inference time by up to 63%. Beyond these compression effects, comparable cost improvements are also observed when distilling into a student model of identical architectural capacity. Overall, our results show that knowledge distillation makes Decision Transformer control more applicable for residential energy management on resource-limited hardware.

Matthias Hertel, Sebastian Pütz, Ralf Mikut et al.

Time-series forecasts are essential for planning and decision-making in many domains. Explainability is key to building user trust and meeting transparency requirements. Shapley Additive Explanations (SHAP) is a popular explainable AI framework, but it lacks efficient implementations for time series and often assumes feature independence when sampling counterfactuals. We introduce SHAPformer, an accurate, fast and sampling-free explainable time-series forecasting model based on the Transformer architecture. It leverages attention manipulation to make predictions based on feature subsets. SHAPformer generates explanations in under one second, several orders of magnitude faster than the SHAP Permutation Explainer. On synthetic data with ground truth explanations, SHAPformer provides explanations that are true to the data. Applied to real-world electrical load data, it achieves competitive predictive performance and delivers meaningful local and global insights, such as identifying the past load as the key predictor and revealing a distinct model behavior during the Christmas period.

Nils Friederich, Angelo Yamachui Sitcheu, Oliver Neumann et al.

In the biomedical environment, experiments assessing dynamic processes are primarily performed by a human acquisition supervisor. Contemporary implementations of such experiments frequently aim to acquire a maximum number of relevant events from sometimes several hundred parallel, non-synchronous processes. Since in some high-throughput experiments, only one or a few instances of a given process can be observed simultaneously, a strategy for planning and executing an efficient acquisition paradigm is essential. To address this problem, we present two new methods in this paper. The first method, Encoded Dynamic Process (EDP), is Artificial Intelligence (AI)-based and represents dynamic processes so as to allow prediction of pseudo-time values from single still images. Second, with Experiment Automation Pipeline for Dynamic Processes (EAPDP), we present a Machine Learning Operations (MLOps)-based pipeline that uses the extracted knowledge from EDP to efficiently schedule acquisition in biomedical experiments for dynamic processes in practice. In a first experiment, we show that the pre-trained State-Of-The- Art (SOTA) object segmentation method Contour Proposal Networks (CPN) works reliably as a module of EAPDP to extract the relevant object for EDP from the acquired three-dimensional image stack.

Moritz Böhland, Oliver Neumann, Marcel P. Schilling et al.

Automated cell nucleus segmentation and classification are required to assist pathologists in their decision making. The Colon Nuclei Identification and Counting Challenge 2022 (CoNIC Challenge 2022) supports the development and comparability of segmentation and classification methods for histopathological images. In this contribution, we describe our CoNIC Challenge 2022 method ciscNet to segment, classify and count cell nuclei, and report preliminary evaluation results. Our code is available at https://git.scc.kit.edu/ciscnet/ciscnet-conic-2022.

Benedikt Heidrich, Andreas Bartschat, Marian Turowski et al.

Time series data are fundamental for a variety of applications, ranging from financial markets to energy systems. Due to their importance, the number and complexity of tools and methods used for time series analysis is constantly increasing. However, due to unclear APIs and a lack of documentation, researchers struggle to integrate them into their research projects and replicate results. Additionally, in time series analysis there exist many repetitive tasks, which are often re-implemented for each project, unnecessarily costing time. To solve these problems we present \texttt{pyWATTS}, an open-source Python-based package that is a non-sequential workflow automation tool for the analysis of time series data. pyWATTS includes modules with clearly defined interfaces to enable seamless integration of new or existing methods, subpipelining to easily reproduce repetitive tasks, load and save functionality to simply replicate results, and native support for key Python machine learning libraries such as scikit-learn, PyTorch, and Keras.

Vinayak Sharma, Jorge Angel Gonzalez Ordiano, Ralf Mikut et al.

The high penetration of volatile renewable energy sources such as solar make methods for coping with the uncertainty associated with them of paramount importance. Probabilistic forecasts are an example of these methods, as they assist energy planners in their decision-making process by providing them with information about the uncertainty of future power generation. Currently, there is a trend towards the use of deep learning probabilistic forecasting methods. However, the point at which the more complex deep learning methods should be preferred over more simple approaches is not yet clear. Therefore, the current article presents a simple comparison between a long short-term memory neural network and other more simple approaches. The comparison consists of training and comparing models able to provide one-day-ahead probabilistic forecasts for a solar power system. Moreover, the current paper makes use of an open-source dataset provided during the Global Energy Forecasting Competition of 2014 (GEFCom14).

Sourabh Bhide, Ralf Mikut, Maria Leptin et al.

Current in vivo microscopy allows us detailed spatiotemporal imaging (3D+t) of complete organisms and offers insights into their development on the cellular level. Even though the imaging speed and quality is steadily improving, fully-automated segmentation and analysis methods are often not accurate enough. This is particularly true while imaging large samples (100um - 1mm) and deep inside the specimen. Drosophila embryogenesis, widely used as a developmental paradigm, presents an example for such a challenge, especially where cell outlines need to imaged - a general challenge in other systems as well. To deal with the current bottleneck in analyzing quantitatively the 3D+t light-sheet microscopy images of Drosophila embryos, we developed a collection of semi-automatic open-source tools. The presented methods include a semi-automatic masking procedure, automatic projection of non-convex 3D isosurfaces to 2D representations as well as cell segmentation and tracking.

Ralf Mikut, Andreas Bartschat, Wolfgang Doneit et al.

The Matlab toolbox SciXMiner is designed for the visualization and analysis of time series and features with a special focus to classification problems. It was developed at the Institute of Applied Computer Science of the Karlsruhe Institute of Technology (KIT), a member of the Helmholtz Association of German Research Centres in Germany. The aim was to provide an open platform for the development and improvement of data mining methods and its applications to various medical and technical problems. SciXMiner bases on Matlab (tested for the version 2017a). Many functions do not require additional standard toolboxes but some parts of Signal, Statistics and Wavelet toolboxes are used for special cases. The decision to a Matlab-based solution was made to use the wide mathematical functionality of this package provided by The Mathworks Inc. SciXMiner is controlled by a graphical user interface (GUI) with menu items and control elements like popup lists, checkboxes and edit elements. This makes it easier to work with SciXMiner for inexperienced users. Furthermore, an automatization and batch standardization of analyzes is possible using macros. The standard Matlab style using the command line is also available. SciXMiner is an open source software. The download page is http://sourceforge.net/projects/SciXMiner. It is licensed under the conditions of the GNU General Public License (GNU-GPL) of The Free Software Foundation.

Matthias Hertel, Alexandra Nikoltchovska, Sebastian Pütz et al.

Time Series Foundation Models (TSFMs) have recently emerged as general-purpose forecasting models and show considerable potential for applications in energy systems. However, applications in critical infrastructure like power grids require transparency to ensure trust and reliability and cannot rely on pure black-box models. To enhance the transparency of TSFMs, we propose an efficient algorithm for computing Shapley Additive Explanations (SHAP) tailored to these models. The proposed approach leverages the flexibility of TSFMs with respect to input context length and provided covariates. This property enables efficient temporal and covariate masking (selectively withholding inputs), allowing for a scalable explanation of model predictions using SHAP. We evaluate two TSFMs - Chronos-2 and TabPFN-TS - on a day-ahead load forecasting task for a transmission system operator (TSO). In a zero-shot setting, both models achieve predictive performance competitive with a Transformer model trained specifically on multiple years of TSO data. The explanations obtained through our proposed approach align with established domain knowledge, particularly as the TSFMs appropriately use weather and calendar information for load prediction. Overall, we demonstrate that TSFMs can serve as transparent and reliable tools for operational energy forecasting.

Max Kleinebrahm, Jonathan Berrisch, Philipp Eiser et al.

Energy forecasting research faces a persistent comparability gap that makes it difficult to measure consistent progress over time. Reported accuracy gains are often not directly comparable because models are evaluated under study-specific datasets, time periods, information sets, and scoring setups, while widely used benchmarks and competition datasets are typically tied to fixed historical windows. This paper introduces the Energy-Arena, a dynamic benchmarking platform for operational energy time series forecasting that provides a continuously updated reference point as energy systems evolve. The platform operates as an open, API-based submission system and standardizes challenge definitions and submission deadlines aligned with operational constraints. Performance is reported on rolling evaluation windows via persistent leaderboards. By moving from retrospective backtesting to forward-looking benchmarking, the Energy-Arena enforces standardized ex-ante submission and ex-post evaluation, thereby improving transparency by preventing information leakage and retroactive tuning. The platform is publicly available at Energy-Arena.org.

Alina Pleli, Simon Baeuerle, Michel Janus et al.

Unsupervised clustering of wafer map defect patterns is challenging because the appearance of certain defect patterns varies significantly. This includes changing shape, location, density, and rotation of the defect area on the wafer. We present a harvesting approach, which can cluster even challenging defect patterns of wafer maps well. Our approach makes use of a well-known, three-step procedure: feature extraction, dimension reduction, and clustering. The novelty in our approach lies in repeating dimensionality reduction and clustering iteratively while filtering out one cluster per iteration according to its silhouette score. This method leads to an improvement of clustering performance in general and is especially useful for difficult defect patterns. The low computational effort allows for a quick assessment of large datasets and can be used to support manual labeling efforts. We benchmark against related approaches from the literature and show improved results on a real-world industrial dataset.

Simon Baeuerle, Ian F. Mendonca, Kristof Van Laerhoven et al.

Coverage Path Planning of Thermal Interface Materials (TIM) plays a crucial role in the design of power electronics and electronic control units. Up to now, this is done manually by experts or by using optimization approaches with a high computational effort. We propose a novel AI-based approach to generate dispense paths for TIM and similar dispensing applications. It is a drop-in replacement for optimization-based approaches. An Artificial Neural Network (ANN) receives the target cooling area as input and directly outputs the dispense path. Our proposed setup does not require labels and we show its feasibility on multiple target areas. The resulting dispense paths can be directly transferred to automated manufacturing equipment and do not exhibit air entrapments. The approach of using an ANN to predict process parameters for a desired target state in real-time could potentially be transferred to other manufacturing processes.

Stefan Meisenbacher, Kaleb Phipps, Oskar Taubert et al.

Optimizing smart grid operations relies on critical decision-making informed by uncertainty quantification, making probabilistic forecasting a vital tool. Designing such forecasting models involves three key challenges: accurate and unbiased uncertainty quantification, workload reduction for data scientists during the design process, and limitation of the environmental impact of model training. In order to address these challenges, we introduce AutoPQ, a novel method designed to automate and optimize probabilistic forecasting for smart grid applications. AutoPQ enhances forecast uncertainty quantification by generating quantile forecasts from an existing point forecast by using a conditional Invertible Neural Network (cINN). AutoPQ also automates the selection of the underlying point forecasting method and the optimization of hyperparameters, ensuring that the best model and configuration is chosen for each application. For flexible adaptation to various performance needs and available computing power, AutoPQ comes with a default and an advanced configuration, making it suitable for a wide range of smart grid applications. Additionally, AutoPQ provides transparency regarding the electricity consumption required for performance improvements. We show that AutoPQ outperforms state-of-the-art probabilistic forecasting methods while effectively limiting computational effort and hence environmental impact. Additionally and in the context of sustainability, we quantify the electricity consumption required for performance improvements.

Nils Friederich, Angelo Jovin Yamachui Sitcheu, Annika Nassal et al.

Microfluidic Live-Cell Imaging (MLCI) generates high-quality data that allows biotechnologists to study cellular growth dynamics in detail. However, obtaining these continuous data over extended periods is challenging, particularly in achieving accurate and consistent real-time event classification at the intersection of imaging and stochastic biology. To address this issue, we introduce the Experiment Automation Pipeline for Event-Driven Microscopy to Smart Microfluidic Single-Cells Analysis (EAP4EMSIG). In particular, we present initial zero-shot results from the real-time segmentation module of our approach. Our findings indicate that among four State-Of-The- Art (SOTA) segmentation methods evaluated, Omnipose delivers the highest Panoptic Quality (PQ) score of 0.9336, while Contour Proposal Network (CPN) achieves the fastest inference time of 185 ms with the second-highest PQ score of 0.8575. Furthermore, we observed that the vision foundation model Segment Anything is unsuitable for this particular use case.

Thomas Lautenschlager, Nils Friederich, Angelo Jovin Yamachui Sitcheu et al.

High-throughput toxicity testing offers a fast and cost-effective way to test large amounts of compounds. A key component for such systems is the automated evaluation via machine learning models. In this paper, we address critical challenges in this domain and demonstrate how representations learned via self-supervised learning can effectively identify toxicant-induced changes. We provide a proof-of-concept that utilizes the publicly available EmbryoNet dataset, which contains ten zebrafish embryo phenotypes elicited by various chemical compounds targeting different processes in early embryonic development. Our analysis shows that the learned representations using self-supervised learning are suitable for effectively distinguishing between the modes-of-action of different compounds. Finally, we discuss the integration of machine learning models in a physical toxicity testing device in the context of the TOXBOX project.

Simon Baeuerle, Pratik Khanna, Nils Friederich et al.

Foundation Models (FMs) have shown impressive performance on various text and image processing tasks. They can generalize across domains and datasets in a zero-shot setting. This could make them suitable for automated quality inspection during series manufacturing, where various types of images are being evaluated for many different products. Replacing tedious labeling tasks with a simple text prompt to describe anomalies and utilizing the same models across many products would save significant efforts during model setup and implementation. This is a strong advantage over supervised Artificial Intelligence (AI) models, which are trained for individual applications and require labeled training data. We test multiple recent FMs on both custom real-world industrial image data and public image data. We show that all of those models fail on our real-world data, while the very same models perform well on public benchmark datasets.

Pascal Zwick, Nils Friederich, Maximilian Beichter et al.

Enhancing the efficiency of high-quality image generation using Diffusion Models (DMs) is a significant challenge due to the iterative nature of the process. Flow Matching (FM) is emerging as a powerful generative modeling paradigm based on a simulation-free training objective instead of a score-based one used in DMs. Typical FM approaches rely on a Gaussian distribution prior, which induces curved, conditional probability paths between the prior and target data distribution. These curved paths pose a challenge for the Ordinary Differential Equation (ODE) solver, requiring a large number of inference calls to the flow prediction network. To address this issue, we present Learned Distribution-guided Flow Matching (LeDiFlow), a novel scalable method for training FM-based image generation models using a better-suited prior distribution learned via a regression-based auxiliary model. By initializing the ODE solver with a prior closer to the target data distribution, LeDiFlow enables the learning of more computationally tractable probability paths. These paths directly translate to fewer solver steps needed for high-quality image generation at inference time. Our method utilizes a State-Of-The-Art (SOTA) transformer architecture combined with latent space sampling and can be trained on a consumer workstation. We empirically demonstrate that LeDiFlow remarkably outperforms the respective FM baselines. For instance, when operating directly on pixels, our model accelerates inference by up to 3.75x compared to the corresponding pixel-space baseline. Simultaneously, our latent FM model enhances image quality on average by 1.32x in CLIP Maximum Mean Discrepancy (CMMD) metric against its respective baseline.

Nils Friederich, Angelo Jovin Yamachui Sitcheu, Annika Nassal et al.

Microfluidic Live-Cell Imaging (MLCI) yields data on microbial cell factories. However, continuous acquisition is challenging as high-throughput experiments often lack real-time insights, delaying responses to stochastic events. We introduce three components in the Experiment Automation Pipeline for Event-Driven Microscopy to Smart Microfluidic Single-Cell Analysis (EAP4EMSIG): a fast, accurate Multi-Layer Perceptron (MLP)-based autofocusing method predicting the focus offset, an evaluation of real-time segmentation methods and a real-time data analysis dashboard. Our MLP-based autofocusing achieves a Mean Absolute Error (MAE) of 0.105 $μ$m with inference times from 87 ms. Among eleven evaluated Deep Learning (DL) segmentation methods, Cellpose reached a Panoptic Quality (PQ) of 93.36 %, while a distance-based method was fastest (121 ms, Panoptic Quality 93.02 %).

Maximilian Beichter, Nils Friederich, Janik Pinter et al.

Time series foundation models provide a universal solution for generating forecasts to support optimization problems in energy systems. Those foundation models are typically trained in a prediction-focused manner to maximize forecast quality. In contrast, decision-focused learning directly improves the resulting value of the forecast in downstream optimization rather than merely maximizing forecasting quality. The practical integration of forecast values into forecasting models is challenging, particularly when addressing complex applications with diverse instances, such as buildings. This becomes even more complicated when instances possess specific characteristics that require instance-specific, tailored predictions to increase the forecast value. To tackle this challenge, we use decision-focused fine-tuning within time series foundation models to offer a scalable and efficient solution for decision-focused learning applied to the dispatchable feeder optimization problem. To obtain more robust predictions for scarce building data, we use Moirai as a state-of-the-art foundation model, which offers robust and generalized results with few-shot parameter-efficient fine-tuning. Comparing the decision-focused fine-tuned Moirai with a state-of-the-art classical prediction-focused fine-tuning Morai, we observe an improvement of 9.45% in average total daily costs.

Stefan Meisenbacher, Silas Aaron Selzer, Mehdi Dado et al.

Renewable energies and their operation are becoming increasingly vital for the stability of electrical power grids since conventional power plants are progressively being displaced, and their contribution to redispatch interventions is thereby diminishing. In order to consider renewable energies like Wind Power (WP) for such interventions as a substitute, day-ahead forecasts are necessary to communicate their availability for redispatch planning. In this context, automated and scalable forecasting models are required for the deployment to thousands of locally-distributed onshore WP turbines. Furthermore, the irregular interventions into the WP generation capabilities due to redispatch shutdowns pose challenges in the design and operation of WP forecasting models. Since state-of-the-art forecasting methods consider past WP generation values alongside day-ahead weather forecasts, redispatch shutdowns may impact the forecast. Therefore, the present paper highlights these challenges and analyzes state-of-the-art forecasting methods on data sets with both regular and irregular shutdowns. Specifically, we compare the forecasting accuracy of three autoregressive Deep Learning (DL) methods to methods based on WP curve modeling. Interestingly, the latter achieve lower forecasting errors, have fewer requirements for data cleaning during modeling and operation while being computationally more efficient, suggesting their advantages in practical applications.

Simon Baeuerle, Andreas Steimer, Ralf Mikut

Thermal management of power electronics and Electronic Control Units is crucial in times of increasing power densities and limited assembly space. Electric and autonomous vehicles are a prominent application field. Thermal Interface Materials are used to transfer heat from a semiconductor to a heatsink. They are applied along a dispense path onto the semiconductor and spread over its entire surface once the heatsink is joined. To plan this application path, design engineers typically perform an iterative trial-and-error procedure of elaborate simulations and manual experiments. We propose a fully automated optimization approach, which clearly outperforms the current manual path planning and respects all relevant manufacturing constraints. An optimum dispense path increases the reliability of the thermal interface and makes the manufacturing more sustainable by reducing material waste. We show results on multiple real products from automotive series production, including an experimental validation on actual series manufacturing equipment.

Stefan Meisenbacher, Marian Turowski, Kaleb Phipps et al.

Time series forecasting is fundamental for various use cases in different domains such as energy systems and economics. Creating a forecasting model for a specific use case requires an iterative and complex design process. The typical design process includes the five sections (1) data pre-processing, (2) feature engineering, (3) hyperparameter optimization, (4) forecasting method selection, and (5) forecast ensembling, which are commonly organized in a pipeline structure. One promising approach to handle the ever-growing demand for time series forecasts is automating this design process. The present paper, thus, analyzes the existing literature on automated time series forecasting pipelines to investigate how to automate the design process of forecasting models. Thereby, we consider both Automated Machine Learning (AutoML) and automated statistical forecasting methods in a single forecasting pipeline. For this purpose, we firstly present and compare the proposed automation methods for each pipeline section. Secondly, we analyze the automation methods regarding their interaction, combination, and coverage of the five pipeline sections. For both, we discuss the literature, identify problems, give recommendations, and suggest future research. This review reveals that the majority of papers only cover two or three of the five pipeline sections. We conclude that future research has to holistically consider the automation of the forecasting pipeline to enable the large-scale application of time series forecasting.

David Bethge, Philipp Hallgarten, Tobias Grosse-Puppendahl et al.

Deep learning based electroencephalography (EEG) signal processing methods are known to suffer from poor test-time generalization due to the changes in data distribution. This becomes a more challenging problem when privacy-preserving representation learning is of interest such as in clinical settings. To that end, we propose a multi-source learning architecture where we extract domain-invariant representations from dataset-specific private encoders. Our model utilizes a maximum-mean-discrepancy (MMD) based domain alignment approach to impose domain-invariance for encoded representations, which outperforms state-of-the-art approaches in EEG-based emotion classification. Furthermore, representations learned in our pipeline preserve domain privacy as dataset-specific private encoding alleviates the need for conventional, centralized EEG-based deep neural network training approaches with shared parameters.

Marcel P. Schilling, Luca Rettenberger, Friedrich Münke et al.

Recent research in the field of computer vision strongly focuses on deep learning architectures to tackle image processing problems. Deep neural networks are often considered in complex image processing scenarios since traditional computer vision approaches are expensive to develop or reach their limits due to complex relations. However, a common criticism is the need for large annotated datasets to determine robust parameters. Annotating images by human experts is time-consuming, burdensome, and expensive. Thus, support is needed to simplify annotation, increase user efficiency, and annotation quality. In this paper, we propose a generic workflow to assist the annotation process and discuss methods on an abstract level. Thereby, we review the possibilities of focusing on promising samples, image pre-processing, pre-labeling, label inspection, or post-processing of annotations. In addition, we present an implementation of the proposal by means of a developed flexible and extendable software prototype nested in hybrid touchscreen/laptop device.

Oliver Neumann, Nicole Ludwig, Marian Turowski et al.

Deep Neural Networks are able to solve many complex tasks with less engineering effort and better performance. However, these networks often use data for training and evaluation without investigating its representation, i.e.~the form of the used data. In the present paper, we analyze the impact of data representations on the performance of Deep Neural Networks using energy time series forecasting. Based on an overview of exemplary data representations, we select four exemplary data representations and evaluate them using two different Deep Neural Network architectures and three forecasting horizons on real-world energy time series. The results show that, depending on the forecast horizon, the same data representations can have a positive or negative impact on the accuracy of Deep Neural Networks.

Stefan Meisenbacher, Janik Pinter, Tim Martin et al.

Undoubtedly, the increase of available data and competitive machine learning algorithms has boosted the popularity of data-driven modeling in energy systems. Applications are forecasts for renewable energy generation and energy consumption. Forecasts are elementary for sector coupling, where energy-consuming sectors are interconnected with the power-generating sector to address electricity storage challenges by adding flexibility to the power system. However, the large-scale application of machine learning methods in energy systems is impaired by the need for expert knowledge, which covers machine learning expertise and a profound understanding of the application's process. The process knowledge is required for the problem formalization, as well as the model validation and application. The machine learning skills include the processing steps of i) data pre-processing, ii) feature engineering, extraction, and selection, iii) algorithm selection, iv) hyperparameter optimization, and possibly v) post-processing of the model's output. Tailoring a model for a particular application requires selecting the data, designing various candidate models and organizing the data flow between the processing steps, selecting the most suitable model, and monitoring the model during operation - an iterative and time-consuming procedure. Automated design and operation of machine learning aim to reduce the human effort to address the increasing demand for data-driven models. We define five levels of automation for forecasting in alignment with the SAE standard for autonomous vehicles, where manual design and application reflect Automation level 0.

Moritz Weber, Marian Turowski, Hüseyin K. Çakmak et al.

A cornerstone of the worldwide transition to smart grids are smart meters. Smart meters typically collect and provide energy time series that are vital for various applications, such as grid simulations, fault-detection, load forecasting, load analysis, and load management. Unfortunately, these time series are often characterized by missing values that must be handled before the data can be used. A common approach to handle missing values in time series is imputation. However, existing imputation methods are designed for power time series and do not take into account the total energy of gaps, resulting in jumps or constant shifts when imputing energy time series. In order to overcome these issues, the present paper introduces the new Copy-Paste Imputation (CPI) method for energy time series. The CPI method copies data blocks with similar properties and pastes them into gaps of the time series while preserving the total energy of each gap. The new method is evaluated on a real-world dataset that contains six shares of artificially inserted missing values between 1 and 30%. It outperforms by far the three benchmark imputation methods selected for comparison. The comparison furthermore shows that the CPI method uses matching patterns and preserves the total energy of each gap while requiring only a moderate run-time.

Simon Baeuerle, Jonas Barth, Elton Renato Tavares de Menezes et al.

Electronic control units (ECUs) are essential for many automobile components, e.g. engine, anti-lock braking system (ABS), steering and airbags. For some products, the 3D pose of each single ECU needs to be determined during series production. Deep learning approaches can not easily be applied to this problem, because labeled training data is not available in sufficient numbers. Thus, we train state-of-the-art artificial neural networks (ANNs) on purely synthetic training data, which is automatically created from a single CAD file. By randomizing parameters during rendering of training images, we enable inference on RGB images of a real sample part. In contrast to classic image processing approaches, this data-driven approach poses only few requirements regarding the measurement setup and transfers to related use cases with little development effort.

Tim Scherr, Katharina Löffler, Moritz Böhland et al.

The accurate segmentation and tracking of cells in microscopy image sequences is an important task in biomedical research, e.g., for studying the development of tissues, organs or entire organisms. However, the segmentation of touching cells in images with a low signal-to-noise-ratio is still a challenging problem. In this paper, we present a method for the segmentation of touching cells in microscopy images. By using a novel representation of cell borders, inspired by distance maps, our method is capable to utilize not only touching cells but also close cells in the training process. Furthermore, this representation is notably robust to annotation errors and shows promising results for the segmentation of microscopy images containing in the training data underrepresented or not included cell types. For the prediction of the proposed neighbor distances, an adapted U-Net convolutional neural network (CNN) with two decoder paths is used. In addition, we adapt a graph-based cell tracking algorithm to evaluate our proposed method on the task of cell tracking. The adapted tracking algorithm includes a movement estimation in the cost function to re-link tracks with missing segmentation masks over a short sequence of frames. Our combined tracking by detection method has proven its potential in the IEEE ISBI 2020 Cell Tracking Challenge (http://celltrackingchallenge.net/) where we achieved as team KIT-Sch-GE multiple top three rankings including two top performances using a single segmentation model for the diverse data sets.

Geoffroy Chaussonnet, Christian Lieber, Yan Yikang et al.

This technical report investigates the potential of Convolutional Neural Networks to post-process images from primary atomization. Three tasks are investigated. First, the detection and segmentation of liquid droplets in degraded optical conditions. Second, the detection of overlapping ellipses and the prediction of their geometrical characteristics. This task corresponds to extrapolate the hidden contour of an ellipse with reduced visual information. Third, several features of the liquid surface during primary breakup (ligaments, bags, rims) are manually annotated on 15 experimental images. The detector is trained on this minimal database using simple data augmentation and then applied to other images from numerical simulation and from other experiment. In these three tasks, models from the literature based on Convolutional Neural Networks showed very promising results, thus demonstrating the high potential of Deep Learning to post-process liquid atomization. The next step is to embed these models into a unified framework DeepSpray.

Jorge Ángel González Ordiano, Lutz Gröll, Ralf Mikut et al.

Parametric quantile regressions are a useful tool for creating probabilistic energy forecasts. Nonetheless, since classical quantile regressions are trained using a non-differentiable cost function, their creation using complex data mining techniques (e.g., artificial neural networks) may be complicated. This article presents a method that uses a new nearest neighbors quantile filter to obtain quantile regressions independently of the utilized data mining technique and without the non-differentiable cost function. Thereafter, a validation of the presented method using the dataset of the Global Energy Forecasting Competition of 2014 is undertaken. The results show that the presented method is able to solve the competition's task with a similar accuracy and in a similar time as the competition's winner, but requiring a much less powerful computer. This property may be relevant in an online forecasting service for which the fast computation of probabilistic forecasts using not so powerful machines is required.

Nadezhda Prodanova, Johannes Stegmaier, Stephan Allgeier et al.

Transfer learning is a powerful tool to adapt trained neural networks to new tasks. Depending on the similarity of the original task to the new task, the selection of the cut-off layer is critical. For medical applications like tissue classification, the last layers of an object classification network might not be optimal. We found that on real data of human corneal tissues the best feature representation can be found in the middle layers of the Inception-v3 and in the rear layers of the VGG-19 architecture.

Johannes Stegmaier, Thiago V. Spina, Alexandre X. Falcão et al.

Automated segmentation approaches are crucial to quantitatively analyze large-scale 3D microscopy images. Particularly in deep tissue regions, automatic methods still fail to provide error-free segmentations. To improve the segmentation quality throughout imaged samples, we present a new supervoxel-based 3D segmentation approach that outperforms current methods and reduces the manual correction effort. The algorithm consists of gentle preprocessing and a conservative super-voxel generation method followed by supervoxel agglomeration based on local signal properties and a postprocessing step to fix under-segmentation errors using a Convolutional Neural Network. We validate the functionality of the algorithm on manually labeled 3D confocal images of the plant Arabidopis thaliana and compare the results to a state-of-the-art meristem segmentation algorithm.

Julian Arz, Peter Sanders, Johannes Stegmaier et al.

Cell nuclei segmentation is one of the most important tasks in the analysis of biomedical images. With ever-growing sizes and amounts of three-dimensional images to be processed, there is a need for better and faster segmentation methods. Graph-based image segmentation has seen a rise in popularity in recent years, but is seen as very costly with regard to computational demand. We propose a new segmentation algorithm which overcomes these limitations. Our method uses recursive balanced graph partitioning to segment foreground components of a fast and efficient binarization. We construct a model for the cell nuclei to guide the partitioning process. Our algorithm is compared to other state-of-the-art segmentation algorithms in an experimental evaluation on two sets of realistically simulated inputs. Our method is faster, has similar or better quality and an acceptable memory overhead.

Wolfgang Doneit, Ralf Mikut, Markus Reischl

Regression models are increasingly built using datasets which do not follow a design of experiment. Instead, the data is e.g. gathered by an automated monitoring of a technical system. As a consequence, already the input data represents phenomena of the system and violates statistical assumptions of distributions. The input data can show correlations, clusters or other patterns. Further, the distribution of input data influences the reliability of regression models. We propose criteria to quantify typical phenomena of input data for regression and show their suitability with simulated benchmark datasets. ----- Regressionen werden zunehmend auf Datensätzen angewendet, deren Eingangsvektoren nicht durch eine statistische Versuchsplanung festgelegt wurden. Stattdessen werden die Daten beispielsweise durch die passive Beobachtung technischer Systeme gesammelt. Damit bilden bereits die Eingangsdaten Phänomene des Systems ab und widersprechen statistischen Verteilungsannahmen. Die Verteilung der Eingangsdaten hat Einfluss auf die Zuverlässigkeit eines Regressionsmodells. Wir stellen deshalb Bewertungskriterien für einige typische Phänomene in Eingangsdaten von Regressionen vor und zeigen ihre Funktionalität anhand simulierter Benchmarkdatensätze.