Tran Minh Son Le

Manuel Haussmann, Tran Minh Son Le, Viivi Halla-aho et al.

Randomized controlled trials (RCTs) are the accepted standard for treatment effect estimation but they can be infeasible due to ethical reasons and prohibitive costs. Single-arm trials, where all patients belong to the treatment group, can be a viable alternative but require access to an external control group. We propose an identifiable deep latent-variable model for this scenario that can also account for missing covariate observations by modeling their structured missingness patterns. Our method uses amortized variational inference to learn both group-specific and identifiable shared latent representations, which can subsequently be used for {\em (i)} patient matching if treatment outcomes are not available for the treatment group, or for {\em (ii)} direct treatment effect estimation assuming outcomes are available for both groups. We evaluate the model on a public benchmark as well as on a data set consisting of a published RCT study and real-world electronic health records. Compared to previous methods, our results show improved performance both for direct treatment effect estimation as well as for effect estimation via patient matching.

Soufiane Amini, Yassine Benajiba, Cesare Bernardis et al. · ibm-research

The proliferation of agent frameworks has led to fragmentation in how agents are defined, executed, and evaluated. Existing systems differ in their abstractions, data flow semantics, and tool integrations, making it difficult to share or reproduce workflows. We introduce Open Agent Specification (Agent Spec), a declarative language that defines AI agents and agentic workflows in a way that is compatible across frameworks, promoting reusability, portability and interoperability of AI agents. Agent Spec defines a common set of components, control and data flow semantics, and schemas that allow an agent to be defined once and executed across different runtimes. Agent Spec also introduces a standardized Evaluation harness to assess agent behavior and agentic workflows across runtimes - analogous to how HELM and related harnesses standardized LLM evaluation - so that performance, robustness, and efficiency can be compared consistently across frameworks. We demonstrate this using four distinct runtimes (LangGraph, CrewAI, AutoGen, and WayFlow) evaluated over three different benchmarks (SimpleQA Verified, $τ^2$-Bench and BIRD-SQL). We provide accompanying toolsets: a Python SDK (PyAgentSpec), a reference runtime (WayFlow), and adapters for popular frameworks (e.g., LangGraph, AutoGen, CrewAI). Agent Spec bridges the gap between model-centric and agent-centric standardization & evaluation, laying the groundwork for reliable, reusable, and portable agentic systems.