Yu Li

Yiming Tan, Dehai Min, Yu Li et al.

ChatGPT is a powerful large language model (LLM) that covers knowledge resources such as Wikipedia and supports natural language question answering using its own knowledge. Therefore, there is growing interest in exploring whether ChatGPT can replace traditional knowledge-based question answering (KBQA) models. Although there have been some works analyzing the question answering performance of ChatGPT, there is still a lack of large-scale, comprehensive testing of various types of complex questions to analyze the limitations of the model. In this paper, we present a framework that follows the black-box testing specifications of CheckList proposed by Ribeiro et. al. We evaluate ChatGPT and its family of LLMs on eight real-world KB-based complex question answering datasets, which include six English datasets and two multilingual datasets. The total number of test cases is approximately 190,000. In addition to the GPT family of LLMs, we also evaluate the well-known FLAN-T5 to identify commonalities between the GPT family and other LLMs. The dataset and code are available at https://github.com/tan92hl/Complex-Question-Answering-Evaluation-of-GPT-family.git

Yu Li, Baolin Peng, Pengcheng He et al. · microsoft-research

Dialogue summarization has recently garnered significant attention due to its wide range of applications. However, existing methods for summarizing dialogues have limitations because they do not take into account the inherent structure of dialogue and rely heavily on labeled data, which can lead to poor performance in new domains. In this work, we propose DIONYSUS (dynamic input optimization in pre-training for dialogue summarization), a pre-trained encoder-decoder model for summarizing dialogues in any new domain. To pre-train DIONYSUS, we create two pseudo summaries for each dialogue example: one is produced by a fine-tuned summarization model, and the other is a collection of dialogue turns that convey important information. We then choose one of these pseudo summaries based on the difference in information distribution across different types of dialogues. This selected pseudo summary serves as the objective for pre-training DIONYSUS using a self-supervised approach on a large dialogue corpus. Our experiments show that DIONYSUS outperforms existing methods on six datasets, as demonstrated by its ROUGE scores in zero-shot and few-shot settings.

Tao Shen, Zhihang Hu, Siqi Sun et al.

Accurate prediction of RNA three-dimensional (3D) structure remains an unsolved challenge. Determining RNA 3D structures is crucial for understanding their functions and informing RNA-targeting drug development and synthetic biology design. The structural flexibility of RNA, which leads to scarcity of experimentally determined data, complicates computational prediction efforts. Here, we present RhoFold+, an RNA language model-based deep learning method that accurately predicts 3D structures of single-chain RNAs from sequences. By integrating an RNA language model pre-trained on ~23.7 million RNA sequences and leveraging techniques to address data scarcity, RhoFold+ offers a fully automated end-to-end pipeline for RNA 3D structure prediction. Retrospective evaluations on RNA-Puzzles and CASP15 natural RNA targets demonstrate RhoFold+'s superiority over existing methods, including human expert groups. Its efficacy and generalizability are further validated through cross-family and cross-type assessments, as well as time-censored benchmarks. Additionally, RhoFold+ predicts RNA secondary structures and inter-helical angles, providing empirically verifiable features that broaden its applicability to RNA structure and function studies.

Kun Qian, Ryan Shea, Yu Li et al.

Along with the development of systems for natural language understanding and generation, dialog systems have been widely adopted for language learning and practicing. Many current educational dialog systems perform chitchat, where the generated content and vocabulary are not constrained. However, for learners in a school setting, practice through dialog is more effective if it aligns with students' curriculum and focuses on textbook vocabulary. Therefore, we adapt lexically constrained decoding to a dialog system, which urges the dialog system to include curriculum-aligned words and phrases in its generated utterances. We adopt a generative dialog system, BlenderBot3, as our backbone model and evaluate our curriculum-based dialog system with middle school students learning English as their second language. The constrained words and phrases are derived from their textbooks, suggested by their English teachers. The evaluation result demonstrates that the dialog system with curriculum infusion improves students' understanding of target words and increases their interest in practicing English.

Fengli Xu, Qianyue Hao, Zefang Zong et al.

Language has long been conceived as an essential tool for human reasoning. The breakthrough of Large Language Models (LLMs) has sparked significant research interest in leveraging these models to tackle complex reasoning tasks. Researchers have moved beyond simple autoregressive token generation by introducing the concept of "thought" -- a sequence of tokens representing intermediate steps in the reasoning process. This innovative paradigm enables LLMs' to mimic complex human reasoning processes, such as tree search and reflective thinking. Recently, an emerging trend of learning to reason has applied reinforcement learning (RL) to train LLMs to master reasoning processes. This approach enables the automatic generation of high-quality reasoning trajectories through trial-and-error search algorithms, significantly expanding LLMs' reasoning capacity by providing substantially more training data. Furthermore, recent studies demonstrate that encouraging LLMs to "think" with more tokens during test-time inference can further significantly boost reasoning accuracy. Therefore, the train-time and test-time scaling combined to show a new research frontier -- a path toward Large Reasoning Model. The introduction of OpenAI's o1 series marks a significant milestone in this research direction. In this survey, we present a comprehensive review of recent progress in LLM reasoning. We begin by introducing the foundational background of LLMs and then explore the key technical components driving the development of large reasoning models, with a focus on automated data construction, learning-to-reason techniques, and test-time scaling. We also analyze popular open-source projects at building large reasoning models, and conclude with open challenges and future research directions.

Shuo Zhang, Junzhou Zhao, Pinghui Wang et al.

Multi-action dialog policy (MADP), which generates multiple atomic dialog actions per turn, has been widely applied in task-oriented dialog systems to provide expressive and efficient system responses. Existing MADP models usually imitate action combinations from the labeled multi-action dialog samples. Due to data limitations, they generalize poorly toward unseen dialog flows. While interactive learning and reinforcement learning algorithms can be applied to incorporate external data sources of real users and user simulators, they take significant manual effort to build and suffer from instability. To address these issues, we propose Planning Enhanced Dialog Policy (PEDP), a novel multi-task learning framework that learns single-action dialog dynamics to enhance multi-action prediction. Our PEDP method employs model-based planning for conceiving what to express before deciding the current response through simulating single-action dialogs. Experimental results on the MultiWOZ dataset demonstrate that our fully supervised learning-based method achieves a solid task success rate of 90.6%, improving 3% compared to the state-of-the-art methods.

David Gros, Yu Li, Zhou Yu

Dialog systems are often designed or trained to output human-like responses. However, some responses may be impossible for a machine to truthfully say (e.g. "that movie made me cry"). Highly anthropomorphic responses might make users uncomfortable or implicitly deceive them into thinking they are interacting with a human. We collect human ratings on the feasibility of approximately 900 two-turn dialogs sampled from 9 diverse data sources. Ratings are for two hypothetical machine embodiments: a futuristic humanoid robot and a digital assistant. We find that for some data-sources commonly used to train dialog systems, 20-30% of utterances are not viewed as possible for a machine. Rating is marginally affected by machine embodiment. We explore qualitative and quantitative reasons for these ratings. Finally, we build classifiers and explore how modeling configuration might affect output permissibly, and discuss implications for building less falsely anthropomorphic dialog systems.

Xingye Chen, Wei Feng, Zhenbang Du et al.

In web data, advertising images are crucial for capturing user attention and improving advertising effectiveness. Most existing methods generate background for products primarily focus on the aesthetic quality, which may fail to achieve satisfactory online performance. To address this limitation, we explore the use of Multimodal Large Language Models (MLLMs) for generating advertising images by optimizing for Click-Through Rate (CTR) as the primary objective. Firstly, we build targeted pre-training tasks, and leverage a large-scale e-commerce multimodal dataset to equip MLLMs with initial capabilities for advertising image generation tasks. To further improve the CTR of generated images, we propose a novel reward model to fine-tune pre-trained MLLMs through Reinforcement Learning (RL), which can jointly utilize multimodal features and accurately reflect user click preferences. Meanwhile, a product-centric preference optimization strategy is developed to ensure that the generated background content aligns with the product characteristics after fine-tuning, enhancing the overall relevance and effectiveness of the advertising images. Extensive experiments have demonstrated that our method achieves state-of-the-art performance in both online and offline metrics. Our code and pre-trained models are publicly available at: https://github.com/Chenguoz/CAIG.

Pengfei Zhang, Zhengyuan Jiang, Yixuan Wang et al.

The reconstruction of microbial genomes from large metagenomic datasets is a critical procedure for finding uncultivated microbial populations and defining their microbial functional roles. To achieve that, we need to perform metagenomic binning, clustering the assembled contigs into draft genomes. Despite the existing computational tools, most of them neglect one important property of the metagenomic data, that is, the noise. To further improve the metagenomic binning step and reconstruct better metagenomes, we propose a deep Contrastive Learning framework for Metagenome Binning (CLMB), which can efficiently eliminate the disturbance of noise and produce more stable and robust results. Essentially, instead of denoising the data explicitly, we add simulated noise to the training data and force the deep learning model to produce similar and stable representations for both the noise-free data and the distorted data. Consequently, the trained model will be robust to noise and handle it implicitly during usage. CLMB outperforms the previous state-of-the-art binning methods significantly, recovering the most near-complete genomes on almost all the benchmarking datasets (up to 17\% more reconstructed genomes compared to the second-best method). It also improves the performance of bin refinement, reconstructing 8-22 more high-quality genomes and 15-32 more middle-quality genomes than the second-best result. Impressively, in addition to being compatible with the binning refiner, single CLMB even recovers on average 15 more HQ genomes than the refiner of VAMB and Maxbin on the benchmarking datasets. CLMB is open-source and available at https://github.com/zpf0117b/CLMB/.

Yu Li, Fan Xu, Fa Zhang et al.

Super-resolution fluorescence microscopy, with a resolution beyond the diffraction limit of light, has become an indispensable tool to directly visualize biological structures in living cells at a nanometer-scale resolution. Despite advances in high-density super-resolution fluorescent techniques, existing methods still have bottlenecks, including extremely long execution time, artificial thinning and thickening of structures, and lack of ability to capture latent structures. Here we propose a novel deep learning guided Bayesian inference approach, DLBI, for the time-series analysis of high-density fluorescent images. Our method combines the strength of deep learning and statistical inference, where deep learning captures the underlying distribution of the fluorophores that are consistent with the observed time-series fluorescent images by exploring local features and correlation along time-axis, and statistical inference further refines the ultrastructure extracted by deep learning and endues physical meaning to the final image. Comprehensive experimental results on both real and simulated datasets demonstrate that our method provides more accurate and realistic local patch and large-field reconstruction than the state-of-the-art method, the 3B analysis, while our method is more than two orders of magnitude faster. The main program is available at https://github.com/lykaust15/DLBI

Jiankai Sun, Chuanyang Zheng, Enze Xie et al.

Reasoning, a crucial ability for complex problem-solving, plays a pivotal role in various real-world settings such as negotiation, medical diagnosis, and criminal investigation. It serves as a fundamental methodology in the field of Artificial General Intelligence (AGI). With the ongoing development of foundation models, e.g., Large Language Models (LLMs), there is a growing interest in exploring their abilities in reasoning tasks. In this paper, we introduce seminal foundation models proposed or adaptable for reasoning, highlighting the latest advancements in various reasoning tasks, methods, and benchmarks. We then delve into the potential future directions behind the emergence of reasoning abilities within foundation models. We also discuss the relevance of multimodal learning, autonomous agents, and super alignment in the context of reasoning. By discussing these future research directions, we hope to inspire researchers in their exploration of this field, stimulate further advancements in reasoning with foundation models, and contribute to the development of AGI.

Chuanyang Zheng, Yihang Gao, Han Shi et al.

Positional encoding plays a crucial role in transformers, significantly impacting model performance and length generalization. Prior research has introduced absolute positional encoding (APE) and relative positional encoding (RPE) to distinguish token positions in given sequences. However, both APE and RPE remain fixed after model training regardless of input data, limiting their adaptability and flexibility. Hence, we expect that the desired positional encoding should be data-adaptive and can be dynamically adjusted with the given attention. In this paper, we propose a Data-Adaptive Positional Encoding (DAPE) method, which dynamically and semantically adjusts based on input context and learned fixed priors. Experimental validation on real-world datasets (Arxiv, Books3, and CHE) demonstrates that DAPE enhances model performances in terms of trained length and length generalization, where the improvements are statistically significant. The model visualization suggests that our model can keep both local and anti-local information. Finally, we successfully train the model on sequence length 128 and achieve better performance at evaluation sequence length 8192, compared with other static positional encoding methods, revealing the benefit of the adaptive positional encoding method.

Junbo Shen, Qinze Yu, Shenyang Chen et al.

Signal peptide (SP) is a short peptide located in the N-terminus of proteins. It is essential to target and transfer transmembrane and secreted proteins to correct positions. Compared with traditional experimental methods to identify signal peptides, computational methods are faster and more efficient, which are more practical for analyzing thousands or even millions of protein sequences, especially for metagenomic data. Here we present Unbiased Organism-agnostic Signal Peptide Network (USPNet), a signal peptide classification and cleavage site prediction deep learning method that takes advantage of protein language models. We propose to apply label distribution-aware margin loss to handle data imbalance problems and use evolutionary information of protein to enrich representation and overcome species information dependence.

Zeyu Li, Chenghui Shi, Yuwen Pu et al.

The widespread use of deep learning technology across various industries has made deep neural network models highly valuable and, as a result, attractive targets for potential attackers. Model extraction attacks, particularly query-based model extraction attacks, allow attackers to replicate a substitute model with comparable functionality to the victim model and present a significant threat to the confidentiality and security of MLaaS platforms. While many studies have explored threats of model extraction attacks against classification models in recent years, object detection models, which are more frequently used in real-world scenarios, have received less attention. In this paper, we investigate the challenges and feasibility of query-based model extraction attacks against object detection models and propose an effective attack method called MEAOD. It selects samples from the attacker-possessed dataset to construct an efficient query dataset using active learning and enhances the categories with insufficient objects. We additionally improve the extraction effectiveness by updating the annotations of the query dataset. According to our gray-box and black-box scenarios experiments, we achieve an extraction performance of over 70% under the given condition of a 10k query budget.

Yijun Yang, Ruiyuan Gao, Yu Li et al.

Adversarial examples (AEs) pose severe threats to the applications of deep neural networks (DNNs) to safety-critical domains, e.g., autonomous driving. While there has been a vast body of AE defense solutions, to the best of our knowledge, they all suffer from some weaknesses, e.g., defending against only a subset of AEs or causing a relatively high accuracy loss for legitimate inputs. Moreover, most existing solutions cannot defend against adaptive attacks, wherein attackers are knowledgeable about the defense mechanisms and craft AEs accordingly. In this paper, we propose a novel AE detection framework based on the very nature of AEs, i.e., their semantic information is inconsistent with the discriminative features extracted by the target DNN model. To be specific, the proposed solution, namely ContraNet, models such contradiction by first taking both the input and the inference result to a generator to obtain a synthetic output and then comparing it against the original input. For legitimate inputs that are correctly inferred, the synthetic output tries to reconstruct the input. On the contrary, for AEs, instead of reconstructing the input, the synthetic output would be created to conform to the wrong label whenever possible. Consequently, by measuring the distance between the input and the synthetic output with metric learning, we can differentiate AEs from legitimate inputs. We perform comprehensive evaluations under various AE attack scenarios, and experimental results show that ContraNet outperforms existing solutions by a large margin, especially under adaptive attacks. Moreover, our analysis shows that successful AEs that can bypass ContraNet tend to have much-weakened adversarial semantics. We have also shown that ContraNet can be easily combined with adversarial training techniques to achieve further improved AE defense capabilities.

Bowen Yang, Cong Han, Yu Li et al.

Conversational recommendation systems (CRS) engage with users by inferring user preferences from dialog history, providing accurate recommendations, and generating appropriate responses. Previous CRSs use knowledge graph (KG) based recommendation modules and integrate KG with language models for response generation. Although KG-based approaches prove effective, two issues remain to be solved. First, KG-based approaches ignore the information in the conversational context but only rely on entity relations and bag of words to recommend items. Second, it requires substantial engineering efforts to maintain KGs that model domain-specific relations, thus leading to less flexibility. In this paper, we propose a simple yet effective architecture comprising a pre-trained language model (PLM) and an item metadata encoder. The encoder learns to map item metadata to embeddings that can reflect the semantic information in the dialog context. The PLM then consumes the semantic-aligned item embeddings together with dialog context to generate high-quality recommendations and responses. Instead of modeling entity relations with KGs, our model reduces engineering complexity by directly converting each item to an embedding. Experimental results on the benchmark dataset ReDial show that our model obtains state-of-the-art results on both recommendation and response generation tasks.

Yu Li, Baolin Peng, Yelong Shen et al.

Knowledge-grounded dialogue systems are challenging to build due to the lack of training data and heterogeneous knowledge sources. Existing systems perform poorly on unseen topics due to limited topics covered in the training data. In addition, heterogeneous knowledge sources make it challenging for systems to generalize to other tasks because knowledge sources in different knowledge representations require different knowledge encoders. To address these challenges, we present PLUG, a language model that homogenizes different knowledge sources to a unified knowledge representation for knowledge-grounded dialogue generation tasks. PLUG is pre-trained on a dialogue generation task conditioned on a unified essential knowledge representation. It can generalize to different downstream knowledge-grounded dialogue generation tasks with a few training examples. The empirical evaluation on two benchmarks shows that our model generalizes well across different knowledge-grounded tasks. It can achieve comparable performance with state-of-the-art methods under a fully-supervised setting and significantly outperforms other methods in zero-shot and few-shot settings.

Xuesong Wang, Zhihang Hu, Tingyang Yu et al.

Muilti-modality data are ubiquitous in biology, especially that we have entered the multi-omics era, when we can measure the same biological object (cell) from different aspects (omics) to provide a more comprehensive insight into the cellular system. When dealing with such multi-omics data, the first step is to determine the correspondence among different modalities. In other words, we should match data from different spaces corresponding to the same object. This problem is particularly challenging in the single-cell multi-omics scenario because such data are very sparse with extremely high dimensions. Secondly, matched single-cell multi-omics data are rare and hard to collect. Furthermore, due to the limitations of the experimental environment, the data are usually highly noisy. To promote the single-cell multi-omics research, we overcome the above challenges, proposing a novel framework to align and integrate single-cell RNA-seq data and single-cell ATAC-seq data. Our approach can efficiently map the above data with high sparsity and noise from different spaces to a low-dimensional manifold in a unified space, making the downstream alignment and integration straightforward. Compared with the other state-of-the-art methods, our method performs better in both simulated and real single-cell data. The proposed method is helpful for the single-cell multi-omics research. The improvement for integration on the simulated data is significant.

Qinze Yu, Zhihang Dong, Xingyu Fan et al.

Identifying the targets of an antimicrobial peptide is a fundamental step in studying the innate immune response and combating antibiotic resistance, and more broadly, precision medicine and public health. There have been extensive studies on the statistical and computational approaches to identify (i) whether a peptide is an antimicrobial peptide (AMP) or a non-AMP and (ii) which targets are these sequences effective to (Gram-positive, Gram-negative, etc.). Despite the existing deep learning methods on this problem, most of them are unable to handle the small AMP classes (anti-insect, anti-parasite, etc.). And more importantly, some AMPs can have multiple targets, which the previous methods fail to consider. In this study, we build a diverse and comprehensive multi-label protein sequence database by collecting and cleaning amino acids from various AMP databases. To generate efficient representations and features for the small classes dataset, we take advantage of a protein language model trained on 250 million protein sequences. Based on that, we develop an end-to-end hierarchical multi-label deep forest framework, HMD-AMP, to annotate AMP comprehensively. After identifying an AMP, it further predicts what targets the AMP can effectively kill from eleven available classes. Extensive experiments suggest that our framework outperforms state-of-the-art models in both the binary classification task and the multi-label classification task, especially on the minor classes.The model is robust against reduced features and small perturbations and produces promising results. We believe HMD-AMP contributes to both the future wet-lab investigations of the innate structural properties of different antimicrobial peptides and build promising empirical underpinnings for precise medicine with antibiotics.

Yu Li, Muhammad Monjurul Karim, Ruwen Qin

Vehicles with a safety function for anticipating crashes in advance can enhance drivers' ability to avoid crashes. As dashboard cameras have become a low-cost sensor device accessible to almost every vehicle, deep neural networks for crash anticipation from a dashboard camera are receiving growing interest. However, drivers' trust in the Artificial Intelligence (AI)-enabled safety function is built on the validation of its safety enhancement toward zero deaths. This paper is motivated to establish a method that uses gaze data and corresponding measures to evaluate human drivers' ability to anticipate crashes. A laboratory experiment is designed and performed, wherein a screen-based eye tracker collects the gaze data of six volunteers while watching 100 driving videos that include both normal and crash scenarios. Statistical analyses of the experimental data show that, on average, drivers can anticipate a crash up to 2.61 seconds before it occurs in this pilot study. The chance that drivers have successfully anticipated crashes before they occur is 92.8%. A state-of-the-art AI model can anticipate crashes 1.02 seconds earlier than drivers on average. The study finds that crash-involving traffic agents in the driving videos can vary drivers' instant attention level, average attention level, and spatial attention distribution. This finding supports the development of a spatial-temporal attention mechanism for AI models to strengthen their ability to anticipate crashes. Results from the comparison also suggest the development of collaborative intelligence that keeps human-in-the-loop of AI models to further enhance the reliability of AI-enabled safety functions.

Junkang Wei, Siyuan Chen, Licheng Zong et al.

Protein-RNA interactions are of vital importance to a variety of cellular activities. Both experimental and computational techniques have been developed to study the interactions. Due to the limitation of the previous database, especially the lack of protein structure data, most of the existing computational methods rely heavily on the sequence data, with only a small portion of the methods utilizing the structural information. Recently, AlphaFold has revolutionized the entire protein and biology field. Foreseeably, the protein-RNA interaction prediction will also be promoted significantly in the upcoming years. In this work, we give a thorough review of this field, surveying both the binding site and binding preference prediction problems and covering the commonly used datasets, features, and models. We also point out the potential challenges and opportunities in this field. This survey summarizes the development of the RBP-RNA interaction field in the past and foresees its future development in the post-AlphaFold era.

Yu Li, Min Li, Qiuxia Lai et al.

Deep learning (DL) has achieved unprecedented success in a variety of tasks. However, DL systems are notoriously difficult to test and debug due to the lack of explainability of DL models and the huge test input space to cover. Generally speaking, it is relatively easy to collect a massive amount of test data, but the labeling cost can be quite high. Consequently, it is essential to conduct test selection and label only those selected "high quality" bug-revealing test inputs for test cost reduction. In this paper, we propose a novel test prioritization technique that brings order into the unlabeled test instances according to their bug-revealing capabilities, namely TestRank. Different from existing solutions, TestRank leverages both intrinsic attributes and contextual attributes of test instances when prioritizing them. To be specific, we first build a similarity graph on test instances and training samples, and we conduct graph-based semi-supervised learning to extract contextual features. Then, for a particular test instance, the contextual features extracted from the graph neural network (GNN) and the intrinsic features obtained with the DL model itself are combined to predict its bug-revealing probability. Finally, TestRank prioritizes unlabeled test instances in descending order of the above probability value. We evaluate the performance of TestRank on a variety of image classification datasets. Experimental results show that the debugging efficiency of our method significantly outperforms existing test prioritization techniques.

Yijun Yang, Ruiyuan Gao, Yu Li et al.

Machine learning with deep neural networks (DNNs) has become one of the foundation techniques in many safety-critical systems, such as autonomous vehicles and medical diagnosis systems. DNN-based systems, however, are known to be vulnerable to adversarial examples (AEs) that are maliciously perturbed variants of legitimate inputs. While there has been a vast body of research to defend against AE attacks in the literature, the performances of existing defense techniques are still far from satisfactory, especially for adaptive attacks, wherein attackers are knowledgeable about the defense mechanisms and craft AEs accordingly. In this work, we propose a multilayer defense-in-depth framework for AE detection, namely MixDefense. For the first layer, we focus on those AEs with large perturbations. We propose to leverage the `noise' features extracted from the inputs to discover the statistical difference between natural images and tampered ones for AE detection. For AEs with small perturbations, the inference result of such inputs would largely deviate from their semantic information. Consequently, we propose a novel learning-based solution to model such contradictions for AE detection. Both layers are resilient to adaptive attacks because there do not exist gradient propagation paths for AE generation. Experimental results with various AE attack methods on image classification datasets show that the proposed MixDefense solution outperforms the existing AE detection techniques by a considerable margin.

Yu Li, Shirley Anugrah Hayati, Weiyan Shi et al.

It is important for sociable recommendation dialog systems to perform as both on-task content and social content to engage users and gain their favor. In addition to understand the user preferences and provide a satisfying recommendation, such systems must be able to generate coherent and natural social conversations to the user. Traditional dialog state tracking cannot be applied to such systems because it does not track the attributes in the social content. To address this challenge, we propose DEUX, a novel attribute-guided framework to create better user experiences while accomplishing a movie recommendation task. DEUX has a module that keeps track of the movie attributes (e.g., favorite genres, actors,etc.) in both user utterances and system responses. This allows the system to introduce new movie attributes in its social content. Then, DEUX has multiple values for the same attribute type which suits the recommendation task since a user may like multiple genres, for instance. Experiments suggest that DEUX outperforms all the baselines on being more consistent, fitting the user preferences better, and providing a more engaging chat experience. Our approach can be used for any similar problems of sociable task-oriented dialog system.

Weiyan Shi, Yu Li, Saurav Sahay et al.

Persuasion dialogue systems reflect the machine's ability to make strategic moves beyond verbal communication, and therefore differentiate themselves from task-oriented or open-domain dialogue systems and have their own unique values. However, the repetition and inconsistency problems still persist in dialogue response generation and could substantially impact user experience and impede the persuasion outcome. Besides, although reinforcement learning (RL) approaches have achieved big success in strategic tasks such as games, they require a sophisticated user simulator to provide real-time feedback to the dialogue system, which limits the application of RL on persuasion dialogues. To address these issues towards a better persuasion dialogue system, we apply RL to refine a language model baseline without user simulators, and distill sentence-level information about repetition, inconsistency, and task relevance through rewards. Moreover, to better accomplish the persuasion task, the model learns from human demonstration to imitate human persuasion behavior and selects the most persuasive responses. Experiments show that our model outperforms previous state-of-the-art dialogue models on both automatic metrics and human evaluation results on a donation persuasion task, and generates more diverse, consistent and persuasive conversations according to the user feedback.

Kaihui Liang, Austin Chau, Yu Li et al.

Gunrock 2.0 is built on top of Gunrock with an emphasis on user adaptation. Gunrock 2.0 combines various neural natural language understanding modules, including named entity detection, linking, and dialog act prediction, to improve user understanding. Its dialog management is a hierarchical model that handles various topics, such as movies, music, and sports. The system-level dialog manager can handle question detection, acknowledgment, error handling, and additional functions, making downstream modules much easier to design and implement. The dialog manager also adapts its topic selection to accommodate different users' profile information, such as inferred gender and personality. The generation model is a mix of templates and neural generation models. Gunrock 2.0 is able to achieve an average rating of 3.73 at its latest build from May 29th to June 4th.

Xinshi Chen, Yu Li, Ramzan Umarov et al.

In this paper, we propose an end-to-end deep learning model, called E2Efold, for RNA secondary structure prediction which can effectively take into account the inherent constraints in the problem. The key idea of E2Efold is to directly predict the RNA base-pairing matrix, and use an unrolled algorithm for constrained programming as the template for deep architectures to enforce constraints. With comprehensive experiments on benchmark datasets, we demonstrate the superior performance of E2Efold: it predicts significantly better structures compared to previous SOTA (especially for pseudoknotted structures), while being as efficient as the fastest algorithms in terms of inference time.

Yu Li, Kun Qian, Weiyan Shi et al.

End-to-end task-oriented dialog models have achieved promising performance on collaborative tasks where users willingly coordinate with the system to complete a given task. While in non-collaborative settings, for example, negotiation and persuasion, users and systems do not share a common goal. As a result, compared to collaborate tasks, people use social content to build rapport and trust in these non-collaborative settings in order to advance their goals. To handle social content, we introduce a hierarchical intent annotation scheme, which can be generalized to different non-collaborative dialog tasks. Building upon TransferTransfo (Wolf et al. 2019), we propose an end-to-end neural network model to generate diverse coherent responses. Our model utilizes intent and semantic slots as the intermediate sentence representation to guide the generation process. In addition, we design a filter to select appropriate responses based on whether these intermediate representations fit the designed task and conversation constraints. Our non-collaborative dialog model guides users to complete the task while simultaneously keeps them engaged. We test our approach on our newly proposed ANTISCAM dataset and an existing PERSUASIONFORGOOD dataset. Both automatic and human evaluations suggest that our model outperforms multiple baselines in these two non-collaborative tasks.

Qingyang Wu, Yichi Zhang, Yu Li et al.

Existing dialog system models require extensive human annotations and are difficult to generalize to different tasks. The recent success of large pre-trained language models such as BERT and GPT-2 (Devlin et al., 2019; Radford et al., 2019) have suggested the effectiveness of incorporating language priors in down-stream NLP tasks. However, how much pre-trained language models can help dialog response generation is still under exploration. In this paper, we propose a simple, general, and effective framework: Alternating Roles Dialog Model (ARDM). ARDM models each speaker separately and takes advantage of the large pre-trained language model. It requires no supervision from human annotations such as belief states or dialog acts to achieve effective conversations. ARDM outperforms or is on par with state-of-the-art methods on two popular task-oriented dialog datasets: CamRest676 and MultiWOZ. Moreover, we can generalize ARDM to more challenging, non-collaborative tasks such as persuasion. In persuasion tasks, ARDM is capable of generating human-like responses to persuade people to donate to a charity.

Ye Tian, Li Yang, Wei Wang et al.

Goal: Squamous cell carcinoma of cervix is one of the most prevalent cancer worldwide in females. Traditionally, the most indispensable diagnosis of cervix squamous carcinoma is histopathological assessment which is achieved under microscope by pathologist. However, human evaluation of pathology slide is highly depending on the experience of pathologist, thus big inter- and intra-observer variability exists. Digital pathology, in combination with deep learning provides an opportunity to improve the objectivity and efficiency of histopathologic slide analysis. Methods: In this study, we obtained 800 haematoxylin and eosin stained slides from 300 patients suffered from cervix squamous carcinoma. Based on information from morphological heterogeneity in the tumor and its adjacent area, we established deep learning models using popular convolution neural network architectures (inception-v3, InceptionResnet-v2 and Resnet50). Then random forest was introduced to feature extractions and slide-based classification. Results: The overall performance of our proposed models on slide-based tumor discrimination were outstanding with an AUC scores > 0.94. While, location identifications of lesions in whole slide images were mediocre (FROC scores > 0.52) duo to the extreme complexity of tumor tissues. Conclusion: For the first time, our analysis workflow highlighted a quantitative visual-based slide analysis of cervix squamous carcinoma. Significance: This study demonstrates a pathway to assist pathologist and accelerate the diagnosis of patients by utilizing new computational approaches.

Bo Luo, Min Li, Yu Li et al.

Machine learning systems based on deep neural networks (DNNs) have gained mainstream adoption in many applications. Recently, however, DNNs are shown to be vulnerable to adversarial example attacks with slight perturbations on the inputs. Existing defense mechanisms against such attacks try to improve the overall robustness of the system, but they do not differentiate different targeted attacks even though the corresponding impacts may vary significantly. To tackle this problem, we propose a novel configurable defense mechanism in this work, wherein we are able to flexibly tune the robustness of the system against different targeted attacks to satisfy application requirements. This is achieved by refining the DNN loss function with an attack sensitive matrix to represent the impacts of different targeted attacks. Experimental results on CIFAR-10 and GTSRB data sets demonstrate the efficacy of the proposed solution.

Qiming Zou, Ling Wang, Ke Lu et al.

Direct policy search is one of the most important algorithm of reinforcement learning. However, learning from scratch needs a large amount of experience data and can be easily prone to poor local optima. In addition to that, a partially trained policy tends to perform dangerous action to agent and environment. In order to overcome these challenges, this paper proposed a policy initialization algorithm called Policy Learning based on Completely Behavior Cloning (PLCBC). PLCBC first transforms the Model Predictive Control (MPC) controller into a piecewise affine (PWA) function using multi-parametric programming, and uses a neural network to express this function. By this way, PLCBC can completely clone the MPC controller without any performance loss, and is totally training-free. The experiments show that this initialization strategy can help agent learn at the high reward state region, and converge faster and better.

Lingxiao Wei, Bo Luo, Yu Li et al.

Deep learning has become the de-facto computational paradigm for various kinds of perception problems, including many privacy-sensitive applications such as online medical image analysis. No doubt to say, the data privacy of these deep learning systems is a serious concern. Different from previous research focusing on exploiting privacy leakage from deep learning models, in this paper, we present the first attack on the implementation of deep learning models. To be specific, we perform the attack on an FPGA-based convolutional neural network accelerator and we manage to recover the input image from the collected power traces without knowing the detailed parameters in the neural network. For the MNIST dataset, our power side-channel attack is able to achieve up to 89% recognition accuracy.

Li Yu, Cyril Joly, Guillaume Bresson et al.

This paper presents a metric global localization in the urban environment only with a monocular camera and the Google Street View database. We fully leverage the abundant sources from the Street View and benefits from its topo-metric structure to build a coarse-to-fine positioning, namely a topological place recognition process and then a metric pose estimation by local bundle adjustment. Our method is tested on a 3 km urban environment and demonstrates both sub-meter accuracy and robustness to viewpoint changes, illumination and occlusion. To our knowledge, this is the first work that studies the global urban localization simply with a single camera and Street View.