Robust High-dimensional Tuning Free Multiple Testing
This addresses the need for reliable large-scale multiple testing in fields like genomics or finance where data often have heavy tails, though it is incremental as it builds on existing estimators.
The paper tackles the problem of robust statistical inference in high-dimensional data with heavy tails by proposing tuning-free and moment-free methods based on the Hodges-Lehmann estimator, and it shows that these methods control false discovery proportion at a prescribed level.
A stylized feature of high-dimensional data is that many variables have heavy tails, and robust statistical inference is critical for valid large-scale statistical inference. Yet, the existing developments such as Winsorization, Huberization and median of means require the bounded second moments and involve variable-dependent tuning parameters, which hamper their fidelity in applications to large-scale problems. To liberate these constraints, this paper revisits the celebrated Hodges-Lehmann (HL) estimator for estimating location parameters in both the one- and two-sample problems, from a non-asymptotic perspective. Our study develops Berry-Esseen inequality and Cramér type moderate deviation for the HL estimator based on newly developed non-asymptotic Bahadur representation, and builds data-driven confidence intervals via a weighted bootstrap approach. These results allow us to extend the HL estimator to large-scale studies and propose \emph{tuning-free} and \emph{moment-free} high-dimensional inference procedures for testing global null and for large-scale multiple testing with false discovery proportion control. It is convincingly shown that the resulting tuning-free and moment-free methods control false discovery proportion at a prescribed level. The simulation studies lend further support to our developed theory.