Yasha Wang

Jinyang Zhang, Hongxin Ding, Yue Fang et al.

Recent work has sought to understand Large Language Models (LLMs) reasoning, yet a principled, model-intrinsic signal that captures its layer-wise reasoning dynamics remains underexplored. We bridge this gap by demonstrating that the l2 norm of hidden states serves as an endogenous signal of the model's reasoning intensity. Using Sparse Autoencoders (SAEs) as a diagnostic probe, we observe that LLMs' internal reasoning is marked by a sharp increase in reasoning feature activations concentrated in late layers. Motivated by this pattern, we establish a formal link between reasoning intensity and the model's latent geometry and theoretically prove that the l2 norm of hidden states bounds the activation strength of SAE reasoning features. Empirical correlation analysis and causal interventions further validate the l2 norm as a faithful indicator, where heightened norms consistently correspond to critical reasoning steps. We then introduce three test-time scaling techniques guided by l2 norms: (i) Adaptive Layer-wise Reasoning Recursion, (ii) Endogenous Reasoning State Steering, and (iii) l2-guided Response Selection, which requires no additional training or data and is compatible with advanced inference engines. Experiments across model architectures and benchmarks show that l2-norm-based techniques significantly improve reasoning performance, offering a principled yet simple lens to perceive and control LLM latent reasoning dynamics. Our code is available at https://github.com/zjy1298/The-Tell-Tale-Norm.

Xinyu Ma, Xu Chu, Yasha Wang et al.

Graph data augmentation has shown superiority in enhancing generalizability and robustness of GNNs in graph-level classifications. However, existing methods primarily focus on the augmentation in the graph signal space and the graph structure space independently, neglecting the joint interaction between them. In this paper, we address this limitation by formulating the problem as an optimal transport problem that aims to find an optimal inter-graph node matching strategy considering the interactions between graph structures and signals. To solve this problem, we propose a novel graph mixup algorithm called FGWMixup, which seeks a midpoint of source graphs in the Fused Gromov-Wasserstein (FGW) metric space. To enhance the scalability of our method, we introduce a relaxed FGW solver that accelerates FGWMixup by improving the convergence rate from $\mathcal{O}(t^{-1})$ to $\mathcal{O}(t^{-2})$. Extensive experiments conducted on five datasets using both classic (MPNNs) and advanced (Graphormers) GNN backbones demonstrate that FGWMixup effectively improves the generalizability and robustness of GNNs. Codes are available at https://github.com/ArthurLeoM/FGWMixup.

Junyi Gao, Yinghao Zhu, Wenqing Wang et al.

The COVID-19 pandemic has posed a heavy burden to the healthcare system worldwide and caused huge social disruption and economic loss. Many deep learning models have been proposed to conduct clinical predictive tasks such as mortality prediction for COVID-19 patients in intensive care units using Electronic Health Record (EHR) data. Despite their initial success in certain clinical applications, there is currently a lack of benchmarking results to achieve a fair comparison so that we can select the optimal model for clinical use. Furthermore, there is a discrepancy between the formulation of traditional prediction tasks and real-world clinical practice in intensive care. To fill these gaps, we propose two clinical prediction tasks, Outcome-specific length-of-stay prediction and Early mortality prediction for COVID-19 patients in intensive care units. The two tasks are adapted from the naive length-of-stay and mortality prediction tasks to accommodate the clinical practice for COVID-19 patients. We propose fair, detailed, open-source data-preprocessing pipelines and evaluate 17 state-of-the-art predictive models on two tasks, including 5 machine learning models, 6 basic deep learning models and 6 deep learning predictive models specifically designed for EHR data. We provide benchmarking results using data from two real-world COVID-19 EHR datasets. One dataset is publicly available without needing any inquiry and another dataset can be accessed on request. We provide fair, reproducible benchmarking results for two tasks. We deploy all experiment results and models on an online platform. We also allow clinicians and researchers to upload their data to the platform and get quick prediction results using our trained models. We hope our efforts can further facilitate deep learning and machine learning research for COVID-19 predictive modeling.

Yinghao Zhu, Junyi Gao, Zixiang Wang et al.

Large Language Models (LLMs) are increasingly deployed in medicine. However, their utility in non-generative clinical prediction, often presumed inferior to specialized models, remains under-evaluated, leading to ongoing debate within the field and potential for misuse, misunderstanding, or over-reliance due to a lack of systematic benchmarking. Our ClinicRealm study addresses this by benchmarking 15 GPT-style LLMs, 5 BERT-style models, and 11 traditional methods on unstructured clinical notes and structured Electronic Health Records (EHR), while also assessing their reasoning, reliability, and fairness. Key findings reveal a significant shift: for clinical note predictions, leading LLMs (e.g., DeepSeek-V3.1-Think, GPT-5) in zero-shot settings now decisively outperform finetuned BERT models. On structured EHRs, while specialized models excel with ample data, advanced LLMs (e.g., GPT-5, DeepSeek-V3.1-Think) show potent zero-shot capabilities, often surpassing conventional models in data-scarce settings. Notably, leading open-source LLMs can match or exceed proprietary counterparts. These results provide compelling evidence that modern LLMs are competitive tools for non-generative clinical prediction, particularly with unstructured text and offering data-efficient structured data options, thus necessitating a re-evaluation of model selection strategies. This research should serve as an important insight for medical informaticists, AI developers, and clinical researchers, potentially prompting a reassessment of current assumptions and inspiring new approaches to LLM application in predictive healthcare.

Zhongji Zhang, Yuhang Wang, Yinghao Zhu et al.

Emerging diseases present challenges in symptom recognition and timely clinical intervention due to limited available information. An effective prognostic model could assist physicians in making accurate diagnoses and designing personalized treatment plans to prevent adverse outcomes. However, in the early stages of disease emergence, several factors hamper model development: limited data collection, insufficient clinical experience, and privacy and ethical concerns restrict data availability and complicate accurate label assignment. Furthermore, Electronic Medical Record (EMR) data from different diseases or sources often exhibit significant cross-dataset feature misalignment, severely impacting the effectiveness of deep learning models. We present a domain-invariant representation learning method that constructs a transition model between source and target datasets. By constraining the distribution shift of features generated across different domains, we capture domain-invariant features specifically relevant to downstream tasks, developing a unified domain-invariant encoder that achieves better feature representation across various task domains. Experimental results across multiple target tasks demonstrate that our proposed model surpasses competing baseline methods and achieves faster training convergence, particularly when working with limited data. Extensive experiments validate our method's effectiveness in providing more accurate predictions for emerging pandemics and other diseases. Code is publicly available at https://github.com/wang1yuhang/domain_invariant_network.

Chaohe Zhang, Xu Chu, Liantao Ma et al.

Multimodal electronic health record (EHR) data are widely used in clinical applications. Conventional methods usually assume that each sample (patient) is associated with the unified observed modalities, and all modalities are available for each sample. However, missing modality caused by various clinical and social reasons is a common issue in real-world clinical scenarios. Existing methods mostly rely on solving a generative model that learns a mapping from the latent space to the original input space, which is an unstable ill-posed inverse problem. To relieve the underdetermined system, we propose a model solving a direct problem, dubbed learning with Missing Modalities in Multimodal healthcare data (M3Care). M3Care is an end-to-end model compensating the missing information of the patients with missing modalities to perform clinical analysis. Instead of generating raw missing data, M3Care imputes the task-related information of the missing modalities in the latent space by the auxiliary information from each patient's similar neighbors, measured by a task-guided modality-adaptive similarity metric, and thence conducts the clinical tasks. The task-guided modality-adaptive similarity metric utilizes the uncensored modalities of the patient and the other patients who also have the same uncensored modalities to find similar patients. Experiments on real-world datasets show that M3Care outperforms the state-of-the-art baselines. Moreover, the findings discovered by M3Care are consistent with experts and medical knowledge, demonstrating the capability and the potential of providing useful insights and explanations.

Yujie Jin, Xu Chu, Yasha Wang et al.

Domain generalization (DG) aims at generalizing a classifier trained on multiple source domains to an unseen target domain with domain shift. A common pervasive theme in existing DG literature is domain-invariant representation learning with various invariance assumptions. However, prior works restrict themselves to a radical assumption for realworld challenges: If a mapping induced by a deep neural network (DNN) could align the source domains well, then such a mapping aligns a target domain as well. In this paper, we simply take DNNs as feature extractors to relax the requirement of distribution alignment. Specifically, we put forward a novel angular invariance and the accompanied norm shift assumption. Based on the proposed term of invariance, we propose a novel deep DG method called Angular Invariance Domain Generalization Network (AIDGN). The optimization objective of AIDGN is developed with a von-Mises Fisher (vMF) mixture model. Extensive experiments on multiple DG benchmark datasets validate the effectiveness of the proposed AIDGN method.

Weibin Liao, Yinghao Zhu, Xinyuan Wang et al.

UNet and its variants have been widely used in medical image segmentation. However, these models, especially those based on Transformer architectures, pose challenges due to their large number of parameters and computational loads, making them unsuitable for mobile health applications. Recently, State Space Models (SSMs), exemplified by Mamba, have emerged as competitive alternatives to CNN and Transformer architectures. Building upon this, we employ Mamba as a lightweight substitute for CNN and Transformer within UNet, aiming at tackling challenges stemming from computational resource limitations in real medical settings. To this end, we introduce the Lightweight Mamba UNet (LightM-UNet) that integrates Mamba and UNet in a lightweight framework. Specifically, LightM-UNet leverages the Residual Vision Mamba Layer in a pure Mamba fashion to extract deep semantic features and model long-range spatial dependencies, with linear computational complexity. Extensive experiments conducted on two real-world 2D/3D datasets demonstrate that LightM-UNet surpasses existing state-of-the-art literature. Notably, when compared to the renowned nnU-Net, LightM-UNet achieves superior segmentation performance while drastically reducing parameter and computation costs by 116x and 21x, respectively. This highlights the potential of Mamba in facilitating model lightweighting. Our code implementation is publicly available at https://github.com/MrBlankness/LightM-UNet.

Ruizhe Zhang, Yongxin Xu, Yuzhen Xiao et al.

By integrating external knowledge, Retrieval-Augmented Generation (RAG) has become an effective strategy for mitigating the hallucination problems that large language models (LLMs) encounter when dealing with knowledge-intensive tasks. However, in the process of integrating external non-parametric supporting evidence with internal parametric knowledge, inevitable knowledge conflicts may arise, leading to confusion in the model's responses. To enhance the knowledge selection of LLMs in various contexts, some research has focused on refining their behavior patterns through instruction-tuning. Nonetheless, due to the absence of explicit negative signals and comparative objectives, models fine-tuned in this manner may still exhibit undesirable behaviors such as contextual ignorance and contextual overinclusion. To this end, we propose a Knowledge-aware Preference Optimization strategy, dubbed KnowPO, aimed at achieving adaptive knowledge selection based on contextual relevance in real retrieval scenarios. Concretely, we proposed a general paradigm for constructing knowledge conflict datasets, which comprehensively cover various error types and learn how to avoid these negative signals through preference optimization methods. Simultaneously, we proposed a rewriting strategy and data ratio optimization strategy to address preference imbalances. Experimental results show that KnowPO outperforms previous methods for handling knowledge conflicts by over 37\%, while also exhibiting robust generalization across various out-of-distribution datasets.

Yue Fang, Weibin Liao, Yuxin Guo et al.

Clinical Reasoning on Electronic Health Records (EHRs) is a fundamental yet challenging task in modern healthcare. While in-context learning (ICL) offers a promising inference-time adaptation paradigm for large language models (LLMs) in EHR reasoning, existing methods face three fundamental challenges: (1) Perspective Limitation, where data-driven similarity fails to align with LLM reasoning needs and model-driven signals are constrained by limited clinical competence; (2) Cohort Awareness, as demonstrations are selected independently without modeling population-level structure; and (3) Information Aggregation, where redundancy and interaction effects among demonstrations are ignored, leading to diminishing marginal gains. To address these challenges, we propose GraphWalker, a principled demonstration selection framework for EHR-oriented ICL. GraphWalker (i) jointly models patient clinical information and LLM-estimated information gain by integrating data-driven and model-driven perspectives, (ii) incorporates Cohort Discovery to avoid noisy local optima, and (iii) employs a Lazy Greedy Search with Frontier Expansion algorithm to mitigate diminishing marginal returns in information aggregation. Extensive experiments on multiple real-world EHR benchmarks demonstrate that GraphWalker consistently outperforms state-of-the-art ICL baselines, yielding substantial improvements in clinical reasoning performance. Our code is open-sourced at https://github.com/PuppyKnightUniversity/GraphWalker

Liantao Ma, Chaohe Zhang, Junyi Gao et al.

Objective: Peritoneal Dialysis (PD) is one of the most widely used life-supporting therapies for patients with End-Stage Renal Disease (ESRD). Predicting mortality risk and identifying modifiable risk factors based on the Electronic Medical Records (EMR) collected along with the follow-up visits are of great importance for personalized medicine and early intervention. Here, our objective is to develop a deep learning model for a real-time, individualized, and interpretable mortality prediction model - AICare. Method and Materials: Our proposed model consists of a multi-channel feature extraction module and an adaptive feature importance recalibration module. AICare explicitly identifies the key features that strongly indicate the outcome prediction for each patient to build the health status embedding individually. This study has collected 13,091 clinical follow-up visits and demographic data of 656 PD patients. To verify the application universality, this study has also collected 4,789 visits of 1,363 hemodialysis dialysis (HD) as an additional experiment dataset to test the prediction performance, which will be discussed in the Appendix. Results: 1) Experiment results show that AICare achieves 81.6%/74.3% AUROC and 47.2%/32.5% AUPRC for the 1-year mortality prediction task on PD/HD dataset respectively, which outperforms the state-of-the-art comparative deep learning models. 2) This study first provides a comprehensive elucidation of the relationship between the causes of mortality in patients with PD and clinical features based on an end-to-end deep learning model. 3) This study first reveals the pattern of variation in the importance of each feature in the mortality prediction based on built-in interpretability. 4) We develop a practical AI-Doctor interaction system to visualize the trajectory of patients' health status and risk indicators.

Xinyu Ma, Xu Chu, Yasha Wang et al.

In healthcare prediction tasks, it is essential to exploit the correlations between medical features and learn better patient health representations. Existing methods try to estimate feature correlations only from data, or increase the quality of estimation by introducing task-specific medical knowledge. However, such methods either are difficult to estimate the feature correlations due to insufficient training samples, or cannot be generalized to other tasks due to reliance on specific knowledge. There are medical research revealing that not all the medical features are strongly correlated. Thus, to address the issues, we expect to group up strongly correlated features and learn feature correlations in a group-wise manner to reduce the learning complexity without losing generality. In this paper, we propose a general patient health representation learning framework MedFACT. We estimate correlations via measuring similarity between temporal patterns of medical features with kernel methods, and cluster features with strong correlations into groups. The feature group is further formulated as a correlation graph, and we employ graph convolutional networks to conduct group-wise feature interactions for better representation learning. Experiments on two real-world datasets demonstrate the superiority of MedFACT. The discovered medical findings are also confirmed by literature, providing valuable medical insights and explanations.

Ruizhe Zhang, Xinke Jiang, Zhibang Yang et al.

Multi-agent systems based on large language models, particularly centralized architectures, have recently shown strong potential for complex and knowledge-intensive tasks. However, central agents often suffer from unstable long-horizon collaboration due to the lack of memory management, leading to context bloat, error accumulation, and poor cross-task generalization. To address both task-level memory inefficiency and the inability to reuse coordination experience, we propose StackPlanner, a hierarchical multi-agent framework with explicit memory control. StackPlanner addresses these challenges by decoupling high-level coordination from subtask execution with active task-level memory control, and by learning to retrieve and exploit reusable coordination experience via structured experience memory and reinforcement learning. Experiments on multiple deep-search and agent system benchmarks demonstrate the effectiveness of our approach in enabling reliable long-horizon multi-agent collaboration.

Rihong Qiu, Zhibang Yang, Xinke Jiang et al.

Text-to-SQL translates natural language questions into SQL statements grounded in a target database schema. Ensuring the reliability and executability of such systems requires validating generated SQL, but most existing approaches focus only on syntactic correctness, with few addressing semantic validation (detecting misalignments between questions and SQL). As a consequence, effective semantic validation still faces two key challenges: capturing both global user intent and SQL structural details, and constructing high-quality fine-grained sub-SQL annotations. To tackle these, we introduce HEROSQL, a hierarchical SQL representation approach that integrates global intent (via Logical Plans, LPs) and local details (via Abstract Syntax Trees, ASTs). To enable better information propagation, we employ a Nested Message Passing Neural Network (NMPNN) to capture inherent relational information in SQL and aggregate schema-guided semantics across LPs and ASTs. Additionally, to generate high-quality negative samples, we propose an AST-driven sub-SQL augmentation strategy, supporting robust optimization of fine-grained semantic inconsistencies. Extensive experiments conducted on Text-to-SQL validation benchmarks (both in-domain and out-of-domain settings) demonstrate that our approach outperforms existing state-of-the-art methods, achieving an average 9.40% improvement of AUPRC and 12.35% of AUROC in identifying semantic inconsistencies. It excels at detecting fine-grained semantic errors, provides large language models with more granular feedback, and ultimately enhances the reliability and interpretability of data querying platforms.

Yujie Feng, Hao Wang, Jian Li et al.

Continual learning (CL) for large language models (LLMs) aims to enable sequential knowledge acquisition without catastrophic forgetting. Memory replay methods are widely used for their practicality and effectiveness, but most rely on fixed, step-based heuristics that often misalign with the model's actual learning progress, since identical training steps can result in varying degrees of parameter change. Motivated by recent findings that LLM forgetting mirrors the Ebbinghaus human forgetting curve, we propose FOREVER (FORgEtting curVe-inspired mEmory Replay), a novel CL framework that aligns replay schedules with a model-centric notion of time. FOREVER defines model time using the magnitude of optimizer updates, allowing forgetting curve-inspired replay intervals to align with the model's internal evolution rather than raw training steps. Building on this approach, FOREVER incorporates a forgetting curve-based replay scheduler to determine when to replay and an intensity-aware regularization mechanism to adaptively control how to replay. Extensive experiments on three CL benchmarks and models ranging from 0.6B to 13B parameters demonstrate that FOREVER consistently mitigates catastrophic forgetting.

Xinyu Ma, Yifeng Xu, Yang Lin et al.

We introduce DRESS, a novel approach for generating stylized large language model (LLM) responses through representation editing. Existing methods like prompting and fine-tuning are either insufficient for complex style adaptation or computationally expensive, particularly in tasks like NPC creation or character role-playing. Our approach leverages the over-parameterized nature of LLMs to disentangle a style-relevant subspace within the model's representation space to conduct representation editing, ensuring a minimal impact on the original semantics. By applying adaptive editing strengths, we dynamically adjust the steering vectors in the style subspace to maintain both stylistic fidelity and semantic integrity. We develop two stylized QA benchmark datasets to validate the effectiveness of DRESS, and the results demonstrate significant improvements compared to baseline methods such as prompting and ITI. In short, DRESS is a lightweight, train-free solution for enhancing LLMs with flexible and effective style control, making it particularly useful for developing stylized conversational agents. Codes and benchmark datasets are available at https://github.com/ArthurLeoM/DRESS-LLM.

Zhihao Yu, Yujie Jin, Yongxin Xu et al.

While pioneering deep learning methods have made great strides in analyzing electronic health record (EHR) data, they often struggle to fully capture the semantics of diverse medical codes from limited data. The integration of external knowledge from Large Language Models (LLMs) presents a promising avenue for improving healthcare predictions. However, LLM analyses may exhibit significant variance due to ambiguity problems and inconsistency issues, hindering their effective utilization. To address these challenges, we propose IntelliCare, a novel framework that leverages LLMs to provide high-quality patient-level external knowledge and enhance existing EHR models. Concretely, IntelliCare identifies patient cohorts and employs task-relevant statistical information to augment LLM understanding and generation, effectively mitigating the ambiguity problem. Additionally, it refines LLM-derived knowledge through a hybrid approach, generating multiple analyses and calibrating them using both the EHR model and perplexity measures. Experimental evaluations on three clinical prediction tasks across two large-scale EHR datasets demonstrate that IntelliCare delivers significant performance improvements to existing methods, highlighting its potential in advancing personalized healthcare predictions and decision support systems.

Hongxin Ding, Peinie Zou, Zhiyuan Wang et al.

Extracting medical knowledge from healthcare texts enhances downstream tasks like medical knowledge graph construction and clinical decision-making. However, the construction and application of knowledge extraction models lack automation, reusability and unified management, leading to inefficiencies for researchers and high barriers for non-AI experts such as doctors, to utilize knowledge extraction. To address these issues, we propose a ModelOps-based intelligent medical knowledge extraction framework that offers a low-code system for model selection, training, evaluation and optimization. Specifically, the framework includes a dataset abstraction mechanism based on multi-layer callback functions, a reusable model training, monitoring and management mechanism. We also propose a model recommendation method based on dataset similarity, which helps users quickly find potentially suitable models for a given dataset. Our framework provides convenience for researchers to develop models and simplifies model access for non-AI experts such as doctors.

Zhihao Yu, Chaohe Zhang, Yasha Wang et al.

Predicting health risks from electronic health records (EHR) is a topic of recent interest. Deep learning models have achieved success by modeling temporal and feature interaction. However, these methods learn insufficient representations and lead to poor performance when it comes to patients with few visits or sparse records. Inspired by the fact that doctors may compare the patient with typical patients and make decisions from similar cases, we propose a Progressive Prototypical Network (PPN) to select typical patients as prototypes and utilize their information to enhance the representation of the given patient. In particular, a progressive prototype memory and two prototype separation losses are proposed to update prototypes. Besides, a novel integration is introduced for better fusing information from patients and prototypes. Experiments on three real-world datasets demonstrate that our model brings improvement on all metrics. To make our results better understood by physicians, we developed an application at http://ppn.ai-care.top. Our code is released at https://github.com/yzhHoward/PPN.

Hongxin Ding, Yue Fang, Runchuan Zhu et al.

Large Language Models(LLMs) excel in general tasks but struggle in specialized domains like healthcare due to limited domain-specific knowledge.Supervised Fine-Tuning(SFT) data construction for domain adaptation often relies on heuristic methods, such as GPT-4 annotation or manual data selection, with a data-centric focus on presumed diverse, high-quality datasets. However, these methods overlook the model's inherent knowledge distribution, introducing noise, redundancy, and irrelevant data, leading to a mismatch between the selected data and the model's learning task, resulting in suboptimal performance. To address this, we propose a two-stage model-centric data selection framework, Decomposed Difficulty Data Selection (3DS), which aligns data with the model's knowledge distribution for optimized adaptation. In Stage1, we apply Prompt-Driven Data Selection via Explicit Alignment, where the the model filters irrelevant or redundant data based on its internal knowledge. In Stage2, we perform Decomposed Difficulty Data Selection, where data selection is guided by our defined difficulty decomposition, using three metrics: Instruction Understanding, Response Confidence, and Response Correctness. Additionally, an attention-based importance weighting mechanism captures token importance for more accurate difficulty calibration. This two-stage approach ensures the selected data is not only aligned with the model's knowledge and preferences but also appropriately challenging for the model to learn, leading to more effective and targeted domain adaptation. In the case study of the medical domain, our extensive experiments on real-world healthcare datasets demonstrate the superiority of 3DS over exisiting methods in accuracy by over 5.29%. Our dataset and code has been open-sourced at https://github.com/PuppyKnightUniversity/3DS.

Yue Fang, Yuxin Guo, Jiaran Gao et al.

Improving large language models (LLMs) for electronic health record (EHR) reasoning is essential for enabling accurate and generalizable clinical predictions. While LLMs excel at medical text understanding, they underperform on EHR-based prediction tasks due to challenges in modeling temporally structured, high-dimensional data. Existing approaches often rely on hybrid paradigms, where LLMs serve merely as frozen prior retrievers while downstream deep learning (DL) models handle prediction, failing to improve the LLM's intrinsic reasoning capacity and inheriting the generalization limitations of DL models. To this end, we propose EAG-RL, a novel two-stage training framework designed to intrinsically enhance LLMs' EHR reasoning ability through expert attention guidance, where expert EHR models refer to task-specific DL models trained on EHR data. Concretely, EAG-RL first constructs high-quality, stepwise reasoning trajectories using expert-guided Monte Carlo Tree Search to effectively initialize the LLM's policy. Then, EAG-RL further optimizes the policy via reinforcement learning by aligning the LLM's attention with clinically salient features identified by expert EHR models. Extensive experiments on two real-world EHR datasets show that EAG-RL improves the intrinsic EHR reasoning ability of LLMs by an average of 14.62%, while also enhancing robustness to feature perturbations and generalization to unseen clinical domains. These results demonstrate the practical potential of EAG-RL for real-world deployment in clinical prediction tasks. Our code have been available at https://github.com/devilran6/EAG-RL.

Zhibang Yang, Xinke Jiang, Rihong Qiu et al.

Federated Retrieval (FR) routes queries across multiple external knowledge sources, to mitigate hallucinations of LLMs, when necessary external knowledge is distributed. However, existing methods struggle to retrieve high-quality and relevant documents for ambiguous queries, especially in cross-domain scenarios, which significantly limits their effectiveness in supporting downstream generation tasks. Inspired by Dynamic Information Flow (DIF), we propose DFAMS, a novel framework that leverages DIF to identify latent query intents and construct semantically aligned knowledge partitions for accurate retrieval across heterogeneous sources. Specifically, DFAMS probes the DIF in LLMs by leveraging gradient signals from a few annotated queries and employing Shapley value-based attribution to trace neuron activation paths associated with intent recognition and subdomain boundary detection. Then, DFAMS leverages DIF to train an alignment module via multi-prototype contrastive learning, enabling fine-grained intra-source modeling and inter-source semantic alignment across knowledge bases. Experimental results across five benchmarks show that DFAMS outperforms advanced FR methods by up to 14.37\% in knowledge classification accuracy, 5.38\% in retrieval recall, and 6.45\% in downstream QA accuracy, demonstrating its effectiveness in complex FR scenarios. Our code are anonymous available at https://anonymous.4open.science/r/DFAMS/

Weibin Liao, Tianlong Wang, Yinghao Zhu et al.

Medical Lay Language Generation (MLLG) plays a vital role in improving the accessibility of complex scientific content for broader audiences. Recent literature to MLLG commonly employ parameter-efficient fine-tuning methods such as Low-Rank Adaptation (LoRA) to fine-tuning large language models (LLMs) using paired expert-lay language datasets. However, LoRA struggles with the challenges posed by multi-source heterogeneous MLLG datasets. Specifically, through a series of exploratory experiments, we reveal that standard LoRA fail to meet the requirement for semantic fidelity and diverse lay-style generation in MLLG task. To address these limitations, we propose Magical, an asymmetric LoRA architecture tailored for MLLG under heterogeneous data scenarios. Magical employs a shared matrix $A$ for abstractive summarization, along with multiple isolated matrices $B$ for diverse lay-style generation. To preserve semantic fidelity during the lay language generation process, Magical introduces a Semantic Invariance Constraint to mitigate semantic subspace shifts on matrix $A$. Furthermore, to better adapt to diverse lay-style generation, Magical incorporates the Recommendation-guided Switch, an externally interface to prompt the LLM to switch between different matrices $B$. Experimental results on three real-world lay language generation datasets demonstrate that Magical consistently outperforms prompt-based methods, vanilla LoRA, and its recent variants, while also reducing trainable parameters by 31.66%. Our code is publicly available at https://github.com/tianlwang/Magical.git.

Weibin Liao, Xin Gao, Tianyu Jia et al.

Natural Language to SQL (NL2SQL) has emerged as a critical task for enabling seamless interaction with databases. Recent advancements in Large Language Models (LLMs) have demonstrated remarkable performance in this domain. However, existing NL2SQL methods predominantly rely on closed-source LLMs leveraging prompt engineering, while open-source models typically require fine-tuning to acquire domain-specific knowledge. Despite these efforts, open-source LLMs struggle with complex NL2SQL tasks due to the indirect expression of user query objectives and the semantic gap between user queries and database schemas. Inspired by the application of reinforcement learning in mathematical problem-solving to encourage step-by-step reasoning in LLMs, we propose LearNAT (Learning NL2SQL with AST-guided Task Decomposition), a novel framework that improves the performance of open-source LLMs on complex NL2SQL tasks through task decomposition and reinforcement learning. LearNAT introduces three key components: (1) a Decomposition Synthesis Procedure that leverages Abstract Syntax Trees (ASTs) to guide efficient search and pruning strategies for task decomposition, (2) Margin-aware Reinforcement Learning, which employs fine-grained step-level optimization via DPO with AST margins, and (3) Adaptive Demonstration Reasoning, a mechanism for dynamically selecting relevant examples to enhance decomposition capabilities. Extensive experiments on two benchmark datasets, Spider and BIRD, demonstrate that LearNAT enables a 7B-parameter open-source LLM to achieve performance comparable to GPT-4, while offering improved efficiency and accessibility.

Jinyang Zhang, Yue Fang, Hongxin Ding et al.

Conventional continual pretraining (CPT) for large language model (LLM) domain adaptation often suffers from catastrophic forgetting and limited domain capacity. Existing strategies adopt layer expansion, introducing additional trainable parameters to accommodate new knowledge. However, the uniform expansion and updates still entangle general and domain learning, undermining its effectiveness. Our pilot studies reveal that LLMs exhibit functional specialization, where layers and units differentially encode general-critical capabilities, suggesting that parameter expansion and optimization should be function-aware. We then propose ADEPT, Adaptive Expansion and Dynamic Decoupled Tuning for continual pretraining, a two-stage framework for domain-adaptive CPT. ADEPT first performs General-Competence Guided Selective Layer Expansion, duplicating layers least critical for the general domain to increase representational capacity while minimizing interference with general knowledge. It then applies Adaptive Unit-Wise Decoupled Tuning, disentangling parameter units within expanded layers according to their general-domain importance and assigning asymmetric learning rates to balance knowledge injection and retention. Experiments on mathematical and medical benchmarks show that ADEPT outperforms full-parameter CPT by up to 5.76% on the general domain and 5.58% on the target domain with only 15% of parameters tuned and less than 50% training time. Ablation studies, theoretical analysis, and extended investigations further demonstrate the necessity of targeted expansion and decoupled optimization, providing new principles for efficient and robust domain-adaptive CPT. Our code is open-sourced at https://github.com/PuppyKnightUniversity/ADEPT

Zhihao Yu, Liantao Ma, Yasha Wang et al.

Deep learning algorithms, especially Transformer-based models, have achieved significant performance by capturing long-range dependencies and historical information. However, the power of convolution has not been fully investigated. Moreover, most existing works ignore the dynamic interaction among variables and evolutionary noise in series. Addressing these issues, we propose a Hierarchical Memorizing Network (HMNet). In particular, a hierarchical convolution structure is introduced to extract the information from the series at various scales. Besides, we propose a dynamic variable interaction module to learn the varying correlation and an adaptive denoising module to search and exploit similar patterns to alleviate noises. These modules can cooperate with the hierarchical structure from the perspective of fine to coarse grain. Experiments on five benchmarks demonstrate that HMNet significantly outperforms the state-of-the-art models by 10.6% on MSE and 5.7% on MAE. Our code is released at https://github.com/yzhHoward/HMNet.

Yang Lin, Xinyu Ma, Xu Chu et al.

Parameter-efficient fine-tuning methods, represented by LoRA, play an essential role in adapting large-scale pre-trained models to downstream tasks. However, fine-tuning LoRA-series models also faces the risk of overfitting on the training dataset, and yet there's still a lack of theoretical guidance and practical mechanism to control overfitting on LoRA-based PEFT methods. In this paper, we propose a LoRA Dropout mechanism for the LoRA-based methods by introducing random noises to the learnable low-rank matrices and increasing parameter sparsity. We then demonstrate the theoretical mechanism of our LoRA Dropout mechanism from the perspective of sparsity regularization by providing a generalization error bound under this framework. Theoretical results show that appropriate sparsity would help tighten the gap between empirical and generalization risks and thereby control overfitting. Furthermore, based on the LoRA Dropout framework, we introduce a test-time ensemble strategy and provide theoretical evidence demonstrating that the ensemble method can further compress the error bound, and lead to better performance during inference time. Extensive experiments on various NLP tasks provide practical validations of the effectiveness of our LoRA Dropout framework in improving model accuracy and calibration.

Xinke Jiang, Ruizhe Zhang, Yongxin Xu et al.

In this paper, we investigate the retrieval-augmented generation (RAG) based on Knowledge Graphs (KGs) to improve the accuracy and reliability of Large Language Models (LLMs). Recent approaches suffer from insufficient and repetitive knowledge retrieval, tedious and time-consuming query parsing, and monotonous knowledge utilization. To this end, we develop a Hypothesis Knowledge Graph Enhanced (HyKGE) framework, which leverages LLMs' powerful reasoning capacity to compensate for the incompleteness of user queries, optimizes the interaction process with LLMs, and provides diverse retrieved knowledge. Specifically, HyKGE explores the zero-shot capability and the rich knowledge of LLMs with Hypothesis Outputs to extend feasible exploration directions in the KGs, as well as the carefully curated prompt to enhance the density and efficiency of LLMs' responses. Furthermore, we introduce the HO Fragment Granularity-aware Rerank Module to filter out noise while ensuring the balance between diversity and relevance in retrieved knowledge. Experiments on two Chinese medical multiple-choice question datasets and one Chinese open-domain medical Q&A dataset with two LLM turbos demonstrate the superiority of HyKGE in terms of accuracy and explainability.

Xinke Jiang, Rihong Qiu, Yongxin Xu et al.

Graph Neural Networks (GNNs) have become essential in interpreting relational data across various domains, yet, they often struggle to generalize to unseen graph data that differs markedly from training instances. In this paper, we introduce a novel framework called General Retrieval-Augmented Graph Learning (RAGraph), which brings external graph data into the general graph foundation model to improve model generalization on unseen scenarios. On the top of our framework is a toy graph vector library that we established, which captures key attributes, such as features and task-specific label information. During inference, the RAGraph adeptly retrieves similar toy graphs based on key similarities in downstream tasks, integrating the retrieved data to enrich the learning context via the message-passing prompting mechanism. Our extensive experimental evaluations demonstrate that RAGraph significantly outperforms state-of-the-art graph learning methods in multiple tasks such as node classification, link prediction, and graph classification across both dynamic and static datasets. Furthermore, extensive testing confirms that RAGraph consistently maintains high performance without the need for task-specific fine-tuning, highlighting its adaptability, robustness, and broad applicability.

Yongxin Xu, Ruizhe Zhang, Xinke Jiang et al.

Retrieval-Augmented Generation (RAG) offers an effective solution to the issues faced by Large Language Models (LLMs) in hallucination generation and knowledge obsolescence by incorporating externally retrieved knowledge. However, existing methods lack effective control mechanisms for integrating internal and external knowledge. Inspired by human cognitive processes, we propose Parenting, a novel framework that decouples, identifies, and purposefully optimizes parameter subspaces related to adherence and robustness. Specifically, Parenting utilizes a key parameter mining method that combines forward and backward propagation signals to localize subspaces representing different capabilities. Then, Parenting employs a type-tailored tuning strategy, applying specific and appropriate optimizations to different subspaces, aiming to achieve a balanced enhancement of both adherence and robustness. Extensive experiments on various datasets and models validate the effectiveness and generalizability of our method.

Yujie Feng, Xujia Wang, Zexin Lu et al.

Continual learning (CL) is crucial for deploying large language models (LLMs) in dynamic real-world environments without costly retraining. While recent model ensemble and model merging methods guided by parameter importance have gained popularity, they often struggle to balance knowledge transfer and forgetting, mainly due to the reliance on static importance estimates during sequential training. In this paper, we present Recurrent-KIF, a novel CL framework for Recurrent Knowledge Identification and Fusion, which enables dynamic estimation of parameter importance distributions to enhance knowledge transfer. Inspired by human continual learning, Recurrent-KIF employs an inner loop that rapidly adapts to new tasks while identifying important parameters, coupled with an outer loop that globally manages the fusion of new and historical knowledge through redundant knowledge pruning and key knowledge merging. These inner-outer loops iteratively perform multiple rounds of fusion, allowing Recurrent-KIF to leverage intermediate training information and adaptively adjust fusion strategies based on evolving importance distributions. Extensive experiments on two CL benchmarks with various model sizes (from 770M to 13B) demonstrate that Recurrent-KIF effectively mitigates catastrophic forgetting and enhances knowledge transfer.

Zhihao Yu, Xu Chu, Yujie Jin et al.

Electronic health record (EHR) data has emerged as a valuable resource for analyzing patient health status. However, the prevalence of missing data in EHR poses significant challenges to existing methods, leading to spurious correlations and suboptimal predictions. While various imputation techniques have been developed to address this issue, they often obsess unnecessary details and may introduce additional noise when making clinical predictions. To tackle this problem, we propose SMART, a Self-Supervised Missing-Aware RepresenTation Learning approach for patient health status prediction, which encodes missing information via elaborated attentions and learns to impute missing values through a novel self-supervised pre-training approach that reconstructs missing data representations in the latent space. By adopting missing-aware attentions and focusing on learning higher-order representations, SMART promotes better generalization and robustness to missing data. We validate the effectiveness of SMART through extensive experiments on six EHR tasks, demonstrating its superiority over state-of-the-art methods.

Hongxin Ding, Baixiang Huang, Yue Fang et al.

Interactive medical questioning is essential in real-world clinical consultations, where physicians must actively gather information from patients. While medical Large Language Models (LLMs) have shown impressive capabilities in static medical question answering, they predominantly operate under a reactive paradigm: generating answers directly without seeking additional information, which risks incorrect diagnoses in such interactive settings. To address this limitation, we propose ProMed, a reinforcement learning (RL) framework that transitions medical LLMs toward a proactive paradigm, equipping them with the ability to ask clinically valuable questions before decision-making. At the core of ProMed is the Shapley Information Gain (SIG) reward, which quantifies the clinical utility of each question by combining the amount of newly acquired information with its contextual importance, estimated via Shapley values. We integrate SIG into a two-stage training pipeline: (1) SIG-Guided Model Initialization uses Monte Carlo Tree Search (MCTS) to construct high-reward interaction trajectories to supervise the model, and (2) SIG-Augmented Policy Optimization, which integrates SIG and enhances RL with a novel SIG-guided Reward Distribution Mechanism that assigns higher rewards to informative questions for targeted optimization. Extensive experiments on two newly curated partial-information medical benchmarks demonstrate that ProMed significantly outperforms state-of-the-art methods by an average of 6.29% and delivers a 54.45% gain over the reactive paradigm, while also generalizing robustly to out-of-domain cases.

Xin Gao, Yang Lin, Ruiqing Li et al.

Data mining and knowledge discovery are essential aspects of extracting valuable insights from vast datasets. Neural topic models (NTMs) have emerged as a valuable unsupervised tool in this field. However, the predominant objective in NTMs, which aims to discover topics maximizing data likelihood, often lacks alignment with the central goals of data mining and knowledge discovery which is to reveal interpretable insights from large data repositories. Overemphasizing likelihood maximization without incorporating topic regularization can lead to an overly expansive latent space for topic modeling. In this paper, we present an innovative approach to NTMs that addresses this misalignment by introducing contrastive learning measures to assess topic interpretability. We propose a novel NTM framework, named ContraTopic, that integrates a differentiable regularizer capable of evaluating multiple facets of topic interpretability throughout the training process. Our regularizer adopts a unique topic-wise contrastive methodology, fostering both internal coherence within topics and clear external distinctions among them. Comprehensive experiments conducted on three diverse datasets demonstrate that our approach consistently produces topics with superior interpretability compared to state-of-the-art NTMs.

Weibin Liao, Yinghao Zhu, Zhongji Zhang et al.

Analyzing the health status of patients based on Electronic Health Records (EHR) is a fundamental research problem in medical informatics. The presence of extensive missing values in EHR makes it challenging for deep neural networks (DNNs) to directly model the patient's health status. Existing DNNs training protocols, including Impute-then-Regress Procedure and Jointly Optimizing of Impute-n-Regress Procedure, require the additional imputation models to reconstruction missing values. However, Impute-then-Regress Procedure introduces the risk of injecting imputed, non-real data into downstream clinical prediction tasks, resulting in power loss, biased estimation, and poorly performing models, while Jointly Optimizing of Impute-n-Regress Procedure is also difficult to generalize due to the complex optimization space and demanding data requirements. Inspired by the recent advanced literature of learnable prompt in the fields of NLP and CV, in this work, we rethought the necessity of the imputation model in downstream clinical tasks, and proposed Learnable Prompt as Pseudo-Imputation (PAI) as a new training protocol to assist EHR analysis. PAI no longer introduces any imputed data but constructs a learnable prompt to model the implicit preferences of the downstream model for missing values, resulting in a significant performance improvement for all state-of-the-arts EHR analysis models on four real-world datasets across two clinical prediction tasks. Further experimental analysis indicates that PAI exhibits higher robustness in situations of data insufficiency and high missing rates. More importantly, as a plug-and-play protocol, PAI can be easily integrated into any existing or even imperceptible future EHR analysis models.

Yujie Feng, Liming Zhan, Zexin Lu et al.

Regular updates are essential for maintaining up-to-date knowledge in large language models (LLMs). Consequently, various model editing methods have been developed to update specific knowledge within LLMs. However, training-based approaches often struggle to effectively incorporate new knowledge while preserving unrelated general knowledge. To address this challenge, we propose a novel framework called Geometric Knowledge Editing (GeoEdit). GeoEdit utilizes the geometric relationships of parameter updates from fine-tuning to differentiate between neurons associated with new knowledge updates and those related to general knowledge perturbations. By employing a direction-aware knowledge identification method, we avoid updating neurons with directions approximately orthogonal to existing knowledge, thus preserving the model's generalization ability. For the remaining neurons, we integrate both old and new knowledge for aligned directions and apply a "forget-then-learn" editing strategy for opposite directions. Additionally, we introduce an importance-guided task vector fusion technique that filters out redundant information and provides adaptive neuron-level weighting, further enhancing model editing performance. Extensive experiments on two publicly available datasets demonstrate the superiority of GeoEdit over existing state-of-the-art methods.

Zhihao Yu, Xu Chu, Liantao Ma et al.

Irregularly sampled time series are ubiquitous, presenting significant challenges for analysis due to missing values. Despite existing methods address imputation, they predominantly focus on leveraging intra-series information, neglecting the potential benefits that inter-series information could provide, such as reducing uncertainty and memorization effect. To bridge this gap, we propose PRIME, a Prototype Recurrent Imputation ModEl, which integrates both intra-series and inter-series information for imputing missing values in irregularly sampled time series. Our framework comprises a prototype memory module for learning inter-series information, a bidirectional gated recurrent unit utilizing prototype information for imputation, and an attentive prototypical refinement module for adjusting imputations. We conducted extensive experiments on three datasets, and the results underscore PRIME's superiority over the state-of-the-art models by up to 26% relative improvement on mean square error.

Yujie Feng, Jian Li, Xiaoyu Dong et al.

Continual learning (CL) is essential for deploying large language models (LLMs) in dynamic real-world environments without the need for costly retraining. Recent model merging-based methods have attracted significant attention, but they still struggle to effectively manage the trade-off between learning new knowledge and preventing forgetting, a challenge largely stemming from suboptimal number of merges and merging frequency. In this paper, we introduce Adaptive Iterative Model Merging (AimMerging), a novel CL framework that utilizes learning and forgetting signals from the training trajectory to dynamically monitor the model's training status. Guided by dynamic monitoring, the training trajectory-guided merge controller adaptively determines the timing and frequency of iterative fusion, while the rehearsal-based knowledge fusion module computes the merging weights and executes the fusion. Comprehensive experiments on three CL benchmarks with various model sizes (from 770M to 13B) demonstrate that AimMerging achieves significant performance improvements over existing state-of-the-art methods, with an average relative improvement of 80% and 59% on FWT and BWT, respectively. The source code is provided for reproducibility.

Huiya Zhao, Yinghao Zhu, Zixiang Wang et al.

The efficacy of AI agents in healthcare research is hindered by their reliance on static, predefined strategies. This creates a critical limitation: agents can become better tool-users but cannot learn to become better strategic planners, a crucial skill for complex domains like healthcare. We introduce HealthFlow, a self-evolving AI agent that overcomes this limitation through a novel meta-level evolution mechanism. HealthFlow autonomously refines its own high-level problem-solving policies by distilling procedural successes and failures into a durable, strategic knowledge base. To anchor our research and facilitate reproducible evaluation, we introduce EHRFlowBench, a new benchmark featuring complex, realistic health data analysis tasks derived from peer-reviewed clinical research. Our comprehensive experiments demonstrate that HealthFlow's self-evolving approach significantly outperforms state-of-the-art agent frameworks. This work marks a necessary shift from building better tool-users to designing smarter, self-evolving task-managers, paving the way for more autonomous and effective AI for scientific discovery.

Ruizhe Zhang, Xinke Jiang, Yuchen Fang et al.

Graph Neural Networks (GNNs) have shown considerable effectiveness in a variety of graph learning tasks, particularly those based on the message-passing approach in recent years. However, their performance is often constrained by a limited receptive field, a challenge that becomes more acute in the presence of sparse graphs. In light of the power series, which possesses infinite expansion capabilities, we propose a novel Graph Power Filter Neural Network (GPFN) that enhances node classification by employing a power series graph filter to augment the receptive field. Concretely, our GPFN designs a new way to build a graph filter with an infinite receptive field based on the convergence power series, which can be analyzed in the spectral and spatial domains. Besides, we theoretically prove that our GPFN is a general framework that can integrate any power series and capture long-range dependencies. Finally, experimental results on three datasets demonstrate the superiority of our GPFN over state-of-the-art baselines.

Yan Li, Bo An, Junming Ma et al.

Hyper-parameter tuning (HPT) is crucial for many machine learning (ML) algorithms. But due to the large searching space, HPT is usually time-consuming and resource-intensive. Nowadays, many researchers use public cloud resources to train machine learning models, convenient yet expensive. How to speed up the HPT process while at the same time reduce cost is very important for cloud ML users. In this paper, we propose SpotTune, an approach that exploits transient revocable resources in the public cloud with some tailored strategies to do HPT in a parallel and cost-efficient manner. Orchestrating the HPT process upon transient servers, SpotTune uses two main techniques, fine-grained cost-aware resource provisioning, and ML training trend predicting, to reduce the monetary cost and runtime of HPT processes. Our evaluations show that SpotTune can reduce the cost by up to 90% and achieve a 16.61x performance-cost rate improvement.

Liantao Ma, Xinyu Ma, Junyi Gao et al.

Due to the characteristics of COVID-19, the epidemic develops rapidly and overwhelms health service systems worldwide. Many patients suffer from systemic life-threatening problems and need to be carefully monitored in ICUs. Thus the intelligent prognosis is in an urgent need to assist physicians to take an early intervention, prevent the adverse outcome, and optimize the medical resource allocation. However, in the early stage of the epidemic outbreak, the data available for analysis is limited due to the lack of effective diagnostic mechanisms, rarity of the cases, and privacy concerns. In this paper, we propose a deep-learning-based approach, CovidCare, which leverages the existing electronic medical records to enhance the prognosis for inpatients with emerging infectious diseases. It learns to embed the COVID-19-related medical features based on massive existing EMR data via transfer learning. The transferred parameters are further trained to imitate the teacher model's representation behavior based on knowledge distillation, which embeds the health status more comprehensively in the source dataset. We conduct the length of stay prediction experiments for patients on a real-world COVID-19 dataset. The experiment results indicate that our proposed model consistently outperforms the comparative baseline methods. CovidCare also reveals that, 1) hs-cTnI, hs-CRP and Platelet Counts are the most fatal biomarkers, whose abnormal values usually indicate emergency adverse outcome. 2) Normal values of gamma-GT, AP and eGFR indicate the overall improvement of health. The medical findings extracted by CovidCare are empirically confirmed by human experts and medical literatures.

Junyi Gao, Cao Xiao, Yasha Wang et al.

Deep learning has demonstrated success in health risk prediction especially for patients with chronic and progressing conditions. Most existing works focus on learning disease Network (StageNet) model to extract disease stage information from patient data and integrate it into risk prediction. StageNet is enabled by (1) a stage-aware long short-term memory (LSTM) module that extracts health stage variations unsupervisedly; (2) a stage-adaptive convolutional module that incorporates stage-related progression patterns into risk prediction. We evaluate StageNet on two real-world datasets and show that StageNet outperforms state-of-the-art models in risk prediction task and patient subtyping task. Compared to the best baseline model, StageNet achieves up to 12% higher AUPRC for risk prediction task on two real-world patient datasets. StageNet also achieves over 58% higher Calinski-Harabasz score (a cluster quality metric) for a patient subtyping task.

Liantao Ma, Chaohe Zhang, Yasha Wang et al.

Predicting the patient's clinical outcome from the historical electronic medical records (EMR) is a fundamental research problem in medical informatics. Most deep learning-based solutions for EMR analysis concentrate on learning the clinical visit embedding and exploring the relations between visits. Although those works have shown superior performances in healthcare prediction, they fail to explore the personal characteristics during the clinical visits thoroughly. Moreover, existing works usually assume that the more recent record weights more in the prediction, but this assumption is not suitable for all conditions. In this paper, we propose ConCare to handle the irregular EMR data and extract feature interrelationship to perform individualized healthcare prediction. Our solution can embed the feature sequences separately by modeling the time-aware distribution. ConCare further improves the multi-head self-attention via the cross-head decorrelation, so that the inter-dependencies among dynamic features and static baseline information can be effectively captured to form the personal health context. Experimental results on two real-world EMR datasets demonstrate the effectiveness of ConCare. The medical findings extracted by ConCare are also empirically confirmed by human experts and medical literature.

Liantao Ma, Junyi Gao, Yasha Wang et al.

Deep learning-based health status representation learning and clinical prediction have raised much research interest in recent years. Existing models have shown superior performance, but there are still several major issues that have not been fully taken into consideration. First, the historical variation pattern of the biomarker in diverse time scales plays a vital role in indicating the health status, but it has not been explicitly extracted by existing works. Second, key factors that strongly indicate the health risk are different among patients. It is still challenging to adaptively make use of the features for patients in diverse conditions. Third, using prediction models as the black box will limit the reliability in clinical practice. However, none of the existing works can provide satisfying interpretability and meanwhile achieve high prediction performance. In this work, we develop a general health status representation learning model, named AdaCare. It can capture the long and short-term variations of biomarkers as clinical features to depict the health status in multiple time scales. It also models the correlation between clinical features to enhance the ones which strongly indicate the health status and thus can maintain a state-of-the-art performance in terms of prediction accuracy while providing qualitative interpretability. We conduct a health risk prediction experiment on two real-world datasets. Experiment results indicate that AdaCare outperforms state-of-the-art approaches and provides effective interpretability, which is verifiable by clinical experts.

Junyi Gao, Weihao Tan, Liantao Ma et al.

Researches have shown that diet recording can help people increase awareness of food intake and improve nutrition management, and thereby maintain a healthier life. Recently, researchers have been working on smartphone-based diet recording methods and applications that help users accomplish two tasks: record what they eat and how much they eat. Although the former task has made great progress through adopting image recognition technology, it is still a challenge to estimate the volume of foods accurately and conveniently. In this paper, we propose a novel method, named MUSEFood, for food volume estimation. MUSEFood uses the camera to capture photos of the food, but unlike existing volume measurement methods, MUSEFood requires neither training images with volume information nor placing a reference object of known size while taking photos. In addition, considering the impact of different containers on the contour shape of foods, MUSEFood uses a multi-task learning framework to improve the accuracy of food segmentation, and uses a differential model applicable for various containers to further reduce the negative impact of container differences on volume estimation accuracy. Furthermore, MUSEFood uses the microphone and the speaker to accurately measure the vertical distance from the camera to the food in a noisy environment, thus scaling the size of food in the image to its actual size. The experiments on real foods indicate that MUSEFood outperforms state-of-the-art approaches, and highly improves the speed of food volume estimation.

Xu Chu, Yang Lin, Jingyue Gao et al.

Drug-drug interactions (DDIs) are a major cause of preventable hospitalizations and deaths. Predicting the occurrence of DDIs helps drug safety professionals allocate investigative resources and take appropriate regulatory action promptly. Traditional DDI prediction methods predict DDIs based on the similarity between drugs. Recently, researchers revealed that predictive performance can be improved by better modeling the interactions between drug pairs with bilinear forms. However, the shallow models leveraging bilinear forms suffer from limitations on capturing complicated nonlinear interactions between drug pairs. To this end, we propose Multi-Label Robust Factorization Autoencoder (abbreviated to MuLFA) for DDI prediction, which learns a representation of interactions between drug pairs and has the capability of characterizing complicated nonlinear interactions more precisely. Moreover, a novel loss called CuXCov is designed to effectively learn the parameters of MuLFA. Furthermore, the decoder is able to generate high-risk chemical structures of drug pairs for specific DDIs, assisting pharmacists to better understand the relationship between drug chemistry and DDI. Experimental results on real-world datasets demonstrate that MuLFA consistently outperforms state-of-the-art methods; particularly, it increases 21:3% predictive performance compared to the best baseline for top 50 frequent DDIs.We also illustrate various case studies to demonstrate the efficacy of the chemical structures generated by MuLFA in DDI diagnosis.

Jiangtao Wang, Feng Wang, Yasha Wang et al.

Worker recruitment is a crucial research problem in Mobile Crowd Sensing (MCS). While previous studies rely on a specified platform with a pre-assumed large user pool, this paper leverages the influenced propagation on the social network to assist the MCS worker recruitment. We first select a subset of users on the social network as initial seeds and push MCS tasks to them. Then, influenced users who accept tasks are recruited as workers, and the ultimate goal is to maximize the coverage. Specifically, to select a near-optimal set of seeds, we propose two algorithms, named Basic-Selector and Fast-Selector, respectively. Basic-Selector adopts an iterative greedy process based on the predicted mobility, which has good performance but suffers from inefficiency concerns. To accelerate the selection, Fast-Selector is proposed, which is based on the interdependency of geographical positions among friends. Empirical studies on two real-world datasets verify that Fast-Selector achieves higher coverage than baseline methods under various settings, meanwhile, it is much more efficient than Basic-Selector while only sacrificing a slight fraction of the coverage.

Jiangtao Wang, Feng Wang, Yasha Wang et al.

Task allocation is a major challenge in Mobile Crowd Sensing (MCS). While previous task allocation approaches follow either the opportunistic or participatory mode, this paper proposes to integrate these two complementary modes in a two-phased hybrid framework called HyTasker. In the offline phase, a group of workers (called opportunistic workers) are selected, and they complete MCS tasks during their daily routines (i.e., opportunistic mode). In the online phase, we assign another set of workers (called participatory workers) and require them to move specifically to perform tasks that are not completed by the opportunistic workers (i.e., participatory mode). Instead of considering these two phases separately, HyTasker jointly optimizes them with a total incentive budget constraint. In particular, when selecting opportunistic workers in the offline phase of HyTasker, we propose a novel algorithm that simultaneously considers the predicted task assignment for the participatory workers, in which the density and mobility of participatory workers are taken into account. Experiments on a real-world mobility dataset demonstrate that HyTasker outperforms other methods with more completed tasks under the same budget constraint.

Jiangtao Wang, Yasha Wang, Daqing Zhang et al.

With the advent of seamless connection of human, machine, and smart things, there is an emerging trend to leverage the power of crowds (e.g., citizens, mobile devices, and smart things) to monitor what is happening in a city, understand how the city is evolving, and further take actions to enable better quality of life, which is referred to as Crowd-Powered Smart City (CPSC). In this article, we provide a literature review for CPSC and identify future research opportunities. Specifically, we first define the concepts with typical CPSC applications. Then, we present the main characteristics of CPSC and further highlight the research issues. In the end, we point out existing limitations which can inform and guide future research directions.