CoC: Chain-of-Cancer based on Cross-Modal Autoregressive Traction for Survival Prediction
This work addresses survival prediction for cancer patients by incorporating epigenetic and textual data, representing an incremental advance over existing methods that rely on pathology and genomics.
The paper tackles survival prediction for cancer patients by introducing a novel framework that integrates four modalities—three clinical data types and language—to improve accuracy, achieving state-of-the-art results across five public cancer datasets.
Survival prediction aims to evaluate the risk level of cancer patients. Existing methods primarily rely on pathology and genomics data, either individually or in combination. From the perspective of cancer pathogenesis, epigenetic changes, such as methylation data, could also be crucial for this task. Furthermore, no previous endeavors have utilized textual descriptions to guide the prediction. To this end, we are the first to explore the use of four modalities, including three clinical modalities and language, for conducting survival prediction. In detail, we are motivated by the Chain-of-Thought (CoT) to propose the Chain-of-Cancer (CoC) framework, focusing on intra-learning and inter-learning. We encode the clinical data as the raw features, which remain domain-specific knowledge for intra-learning. In terms of inter-learning, we use language to prompt the raw features and introduce an Autoregressive Mutual Traction module for synergistic representation. This tailored framework facilitates joint learning among multiple modalities. Our approach is evaluated across five public cancer datasets, and extensive experiments validate the effectiveness of our methods and proposed designs, leading to producing \sota results. Codes will be released.