AuraGenome: An LLM-Powered Framework for On-the-Fly Reusable and Scalable Circular Genome Visualizations
This addresses the challenge for bioinformatics researchers and practitioners who need efficient tools for exploring structural variants and gene regulation, though it appears incremental as it builds on existing visualization concepts with LLM integration.
The authors tackled the problem of complex and error-prone circular genome visualization by introducing AuraGenome, an LLM-powered framework that enables rapid, reusable, and scalable generation of multi-layered visualizations, validated through case studies and a user study.
Circular genome visualizations are essential for exploring structural variants and gene regulation. However, existing tools often require complex scripting and manual configuration, making the process time-consuming, error-prone, and difficult to learn. To address these challenges, we introduce AuraGenome, an LLM-powered framework for rapid, reusable, and scalable generation of multi-layered circular genome visualizations. AuraGenome combines a semantic-driven multi-agent workflow with an interactive visual analytics system. The workflow employs seven specialized LLM-driven agents, each assigned distinct roles such as intent recognition, layout planning, and code generation, to transform raw genomic data into tailored visualizations. The system supports multiple coordinated views tailored for genomic data, offering ring, radial, and chord-based layouts to represent multi-layered circular genome visualizations. In addition to enabling interactions and configuration reuse, the system supports real-time refinement and high-quality report export. We validate its effectiveness through two case studies and a comprehensive user study. AuraGenome is available at: https://github.com/Darius18/AuraGenome.