CeViT: Copula-Enhanced Vision Transformer in multi-task learning and bi-group image covariates with an application to myopia screening
This work addresses a domain-specific challenge in medical imaging for myopia screening, with incremental improvements in model architecture and theoretical interpretability.
The authors tackled the problem of integrating ocular image pairs and modeling dependence between high-myopia status and axial length for myopia screening, resulting in CeViT, which improved classification accuracy and prediction over a baseline model.
We aim to assist image-based myopia screening by resolving two longstanding problems, "how to integrate the information of ocular images of a pair of eyes" and "how to incorporate the inherent dependence among high-myopia status and axial length for both eyes." The classification-regression task is modeled as a novel 4-dimensional muti-response regression, where discrete responses are allowed, that relates to two dependent 3rd-order tensors (3D ultrawide-field fundus images). We present a Vision Transformer-based bi-channel architecture, named CeViT, where the common features of a pair of eyes are extracted via a shared Transformer encoder, and the interocular asymmetries are modeled through separated multilayer perceptron heads. Statistically, we model the conditional dependence among mixture of discrete-continuous responses given the image covariates by a so-called copula loss. We establish a new theoretical framework regarding fine-tuning on CeViT based on latent representations, allowing the black-box fine-tuning procedure interpretable and guaranteeing higher relative efficiency of fine-tuning weight estimation in the asymptotic setting. We apply CeViT to an annotated ultrawide-field fundus image dataset collected by Shanghai Eye \& ENT Hospital, demonstrating that CeViT enhances the baseline model in both accuracy of classifying high-myopia and prediction of AL on both eyes.